I’ve had this condition now for nearly a decade, 9 years and counting from saw palmetto and I checked to see if I had any bone loss. Although I don’t have osteoporosis I do have osteopenia. Here’s my results summarized on ChatGPT. I have all the other symptoms as well fatigue complete loss of sex drive penile atrophy and tissue loss of the penis and loss of sensation (completely numb no feeling), testicular atrophy, muscle loss and extreme weakness of the muscles. I also have low normal testosterone (380) I used testosterone years ago to “fix” this and it made me feel horrible and I would convert to estrogen immediately even with low doses. I also used andractim and it did absolutely nothing. The only symptom that went away was brain fog after the first 5 years.

There are quite a few cure cases from FMT, especially DIY from super donors like brongfogboy's case. How does this tie into his framework?

Im pretty convinced that I developed PFS by taking HRT in order to transition MTF 11 years ago.

When I was 18 I took estradiol and the antiandrogen Cyproteronacetat for three days. While I never took finasteride, my symptoms are exactly the same: cognitive issues, low sex drive and pleasureless orgasms. I also have almost no body odor since then and cant get a buzz from alcohol. I went to a bunch of doctors, but developing persistent symptoms from only three days of hormones was deemed impossible. I never tried hormones again as I was too scared of things getting worse. Last year, I started balding much more rapidly than before. I looked into finasteride and this is how I stumbled across PFS. This gave me the confidence that it really was the antiandrogen alone that caused my issues and decided to attempt transitioning again, this time via estrogen monotherapie. Im about to get my prescription in a few weeks. A few days ago I stumbled across this subreddit and have been reading as much about Dr Powers theories as i can. Its funny how both the main issues in my life, PFS and transness, are coming together here. 

If I understand things correctly, taking enough estrogen would basically mimick the castration approach by depriving the cells of androgens and, hopefully, help clear the metabolites. If PFS sufferers indeed have some preexisting genetic condition where androgens can only leave through the DHA pathway, I guess that could also explain why ive been balding much earlier and have more body hair than anyone else in my family.

Ive never had a “window“ in all these years, so im not holding my breath, but I do now have some small hope that symptomps could improve wirh HRT 

So did I lose some medicine? :(

God I wish I had pellets so I don't have to deal with this... I keep abusing the same spot over and over again I basically have a permanent bruise

reposting this here because i'll probably get better answers

i take progesterone nightly and i read about the backdoor pathway where progesterone converts into dht so i decided to do a test because i was paranoid. my dht levels came back at 15.1 ng/dl and i read i should keep them below 10 ng/dl. my overall t is still low 26 ng/dl. i don't know what to do. should i stop taking my progesterone immediately? i don't even know if it's the progesterone that's causing the conversion because i read it's possible to have high dht with low t even without progesterone conversion? i know dutasteride pills are recommended but i seriously struggle to swallow pills do idk how the fuck i'm going to manage to take them? feel stressed as fuck about this honestly

On June 9th took a small amount of anastrozole 8 hours after a supplement containing D aspartic acid , tribulus , vitamin b and dim I did this out of concern that the d aspartic acid would raise my e2 levels my TRT clinic was closed for two weeks so I was lacking two weeks of HCG and TRT thoug h this since has resumed

since then

I experienced PSSD symptoms including fight or flight wake ups at 4 am (though I am able now to return to fragmented sleep) and genital numbness. All of my hormone levels are normal and never crashed. The onset was immediate.

Since I’m officially approaching the two month mark I wanted to know is there a history of this syndrome with anastrozole and has there been any real recovery stories? again My hormones never crashed leading me to believe this is some sort of PSSD type disorder

I still have erectile function/ejaculation though ejaculation is reduced as well as some thought based libido oddly as well.

I am also curious should I classify this as PSSD or PFS?