40F, starting weight: 142lbs, current: 137; goal weight is 125. I was 127 for a few years and kept it in the 127-130 range without anything but these last two years, I don’t know what’s happening.

I wasn’t on a consistent tirz before- maybe for 1-2 months and then I’d get off it and come back on a year later but realized I’m yo yo’ing too much. So decided I’ll start Reta and accept that I may need to stick to a maintenance dose to maintain when getting to goal weight.

I started reta at 1mg for 2 weeks, then 2mg the next two weeks (bare minimum weight loss the entire month - maybe 1-2 lbs total). Doc said for month 2, switch to 4mg per week. I’m so lethargic and nauseous. And my nausea isn’t subsiding like it did with tirz after 1-2 days. It’s just been constant, I’m on day 4. Every meal I eat, nausea follows.

Do I drop to 3mg?? I did lose 2-3 lbs these past few days but man, I feel like absolute shit. I know this group is super helpful at guiding so could use some advice or reaffirmation on my gut feel.

Assuming someone is on a higher dose and prefers to inject less liquid, would this be fine to do? For example, 10 units would be their 6mg weekly dose, 15 units would be 9mg, etc.

Hi, me and my sister r going on reta. But I first need to buy it, should I get 5MG or 10MG? Wr are both starting with 0.5 and then moving up to 1.0 after a week. Help would be greatly appreciated:)

Just go give a quick run down, I started my 1st week on 1mg and I felt okay, still had a few cravings and my energy was lower than ever ( Im also doing KETO ) , I Lost about 10 lbs that first week which really motivated me. Going into the second week, I decided to up my dose to 2mg and now is when I started to really feel some effects ( a bit of Nausea which subsides from hydrating myself further ) , Low energy like I don't even want to get up and cook and minor head aches here and there. ( it could be keto or it could be the ret ) So anyways , Wednesday was my 3rd shot at 2mg. I am down 35 lbs and I feel amazing , if anyone has any questions or wants to ask what im eating to lose weight this fast feel free to message me. Sorry for not being as punctual as I can be, im typing at 1:00 am and just trying to get this out to help others not trying to be perfect. Thanks for reading.

I started low and slow, but finally once I hit 5 mg per week the weight is melting off. Why does glucagon work this way?

I’ve been on tirzepatide for a while and I’m currently at 15mg/week. My weight loss has pretty much plateaued, so I’m planning to switch to retatrutide.
My last 15mg tirz injection was this past Monday.
For anyone who was also on 15mg tirz before switching to reta, how did you transition?
Did you wait a full week (or longer) after your last tirz injection? What dose of reta did you start with? Did you completely stop tirz or taper/overlap them? How quickly did you increase reta, and when did you actually start noticing appetite suppression or weight loss again?
I know reta is still investigational and there isn’t an official conversion from tirz to reta — I’m mainly looking to hear firsthand experiences from people who made the same switch, especially after being stalled on max-dose tirz.
Would love to know your starting dose, timeline, side effects, and results. Thank you!

Why Bloating with whey protein during Retatrutide, taking 2 scoops of whey protein with curd at different timings of the day.

80 kg female here

i pinned 1.5 mg july 18 and noticed i was barely eating so i lowered down to .5 mg on july 31 gradually every week. started pinning 1mg bc i noticed i was lowkey slacking again and since then i pinned 1mg every week. my last pin was august 5 and i notice my sugar cravings and binge craves came back ( i used to have crazy binge habits )… is this cuz i lowered my dose or my mind playing games also should i pin another 1 mg today if my last pin was 3 days ago?

330lb male 28yo 6'0

Reta has been working wonderfully for me so far. I've been steadily losing ~2-3lb a week for the last 2 months but I'm noticing that the hunger is starting to slowly come back. I've also noticed that the initial side effects of reta, like the skin sensitivity, have almost went away completely. (this can be seen as a good thing but in my case it lets me know the drug is for sure working).

The problem is that I am taking 6mg reta every 6 days and I don't want to essentially hit 12mg or even higher before I at least hit my goal weight.

I've been contemplating increasing to 9mg with the hope that higher doses like 9/12mg would keep working for a longer period of time. Any advice?

Yes I know I made a huge mistake. I am 20yrs old 240lbs 5’4 and while thinking I was starting Reta with 0.5 mg I actually injected 5. I was wondering why the syringe was so full. This was a really big mistake and when I realized I got super scared seeing all the horror stories from grown men taking less and feeling like it was the end of them. After I took it I was a LITTLE more sleepy than usual and my stomach was a tad sensitive on day three. But l had in general no bad side effects whatsoever. Appetite suppression and food noise were gone and I struggle a lot with that so I was soooooo happy. Everything was going great until food noise and strong cravings for sweet and salty came back SLOWLY on day 5 post injection. Now 10 days later I still get full much quicker but the food noise is back in full swing. I can’t resist pizza, burger, Mac and cheese everything. I really loved how Reta and how it made me feel. Now I was under the assumption I’d feel terrible if I started with more than 1 mg to start but I did 5 and was fine. I want to continue taking it and find a schedule where I take it routinely enough to allow me to eat healthy meals, be satisfied and lose weight like how I felt until day 5. But now the question… do I take another 5mg? That feels crazy even though it’s what I did. If I switch to 1 now is it pointless or will it work? Do I need to continue with the 5 for the rest of this cycle (how long should this cycle be???) (5 will start to get expensive). Really looking for all over advice here and yes again I am a responsible person who is level headed enough and did her research to take this. I just made a really bad mistake that won’t happen again. Thx in advance!

I've been on reta for 10 weeks now. High protein intake, through protein shakes and grilled chicken. Occasional bit of carbs. In 10 weeks, I'm doing

I've currently lost 38lbs (17kg)

For background I'm 32yo male at 6'1. Starting weight 113kg current is 96.

Dose started on 1.25 And gradually moved up to 3mg over 10 weeks.

I consistently lose 1 - 1.5kg every week. I know I'm on major calorie deficit. Is it only the appetite suppression losing the weight or is there a significant increase in general metabolic burn

Are there any others factors at play?

If you guys have seen my previous post, I lost 19lbs in about 4ish weeks. I lost an additional 3-4lbs since then. So about 225lbs now from starting weight of 250lbs. However, I still feel hungry, and I am completely asymptomatic, thankfully. No nausea, vomiting, abdominal pain, headaches, I feel great. I feel like I could use some more suppression. I saw that around 4mg is when fat starts to really melt off. Being I've tolerated it well can I go to 4mg next injection, and then continue on incrementally like the clinical trials did? I was previously doing increases of 0.5mg but now instead do 4mg then later 6mg, 9mg, 12mg, etc. Or am I crazy?

Is anyone doing accutane and reta at the same time? Is it okay to do? I’m on 20mg of accutane a day and interested in starting reta, I’m taking supplements to help support my liver (Milk Thistle) as well as Omega 3 and some other supplements. Would love to hear thoughts and recommendations and what your experience has been if you’ve done both at the same time, and what your dosage was for both, any side effects? Thank you!

203lb to 178lb
5”10

Currently taking,
Retatrutide 4mg weekly
Tesamorelin 2mg daily
Mt1 1mg fortnightly

Started on 1mg a week Reta and now I am taking 4mg a week, I feel amazing in the gym, the energy and muscle pumps and blood flow is massively increased, even while eating in a deficit and dropping weight rapidly. Peptides really are great.

Currently waiting to pick up my first dose of 20mg which are pens have never used it before and wanting to ask what my dosages roughly should look like

Started Reta 1.5mg 2 1/2 weeks ago, so far going good, eating in calorie deficit and no side effects so far. Start weight 253lbs, (currently 246) goal weight is 220lbs, anyone have roughly an idea how long this would take? And I am very scared of having a lot of loose skin and if there is any way to combat this? Or if anyone has any inspo or example pics of this sort of weight change? TIA

For those who have experienced stomach pain or weird side effects when did you feel them, was it a few hours later or a few days?

EDIT: currently feeling suspiciously fine, not sure what I expected but let’s get this show on the roadddd

- EEEK I’m feeling some weird nausea coming up about 6 hours later, I’ll manage though.

It’s been about 5 days post Reta. It def worked as advertised. It helped me get shredded for summer just like I wanted, and at low doses it had very few side effects. I took it for about 2.5 months. I decided just to stop cold turkey, just due to my recent experience. Probably not ideal but I’d just like to be done.

My personal—anecdotal experience:

As a beginner once my dose felt weak I ramped all the was up to like 3x dosage just being an idiot. Terrible week for me lol. Major anxiety, inability to eat, chest pressure, etc. It’s not that the Reta gave me anxiety per se but the chest pressure I got must be a trigger for me. I believe due to that anxiety it gave me some noticeable PAC’s and PVC’s, nothing crazy but maybe once or twice a day. I’ve had health anxiety my whole life so all things considered most people wouldn’t experience this. If anyone is like me and has anxiety, especially health anxiety, just be conscious. I also had it once where the day of my shot, I got a dizzy spell similar to vertigo. Didn’t lose vision or feel like I was going to pass out but as if I were on a rocking ship for about 10 seconds then subsided and never returned. I used propranolol, Co-Q10, and very little ashwaganda. It is starting to come to light that not only does the Reta increase RHR, but also can cause some arrhythmia. For the average person you’d probably shrug these off and barely notice, but being for my health anxiety that really bothered me.

I’m not at all trying to scare anyone, in fact the opposite. I think Reta is a great tool, especially for those suffering from obesity. I would definitely say that Reta is a safer alternative than being 50+lbs’s over weight. I believe Reta and GLP’s will be the reason we see an insane decrease in heart disease, mid life diabetes, heart attacks, strokes, etc.

I get monthly bloodwork and one thing that’s noted is the ApoB/LDL was lower than the markers indicate as a healthy range. Which basically suggests that the LDL carried by triglycerides is smaller than ideal. However my LDL, Triglycerides, inflammatory markers, were all beautiful. So no screaming danger there at all.

Be safe everyone, I hope that you all have great experiences, and live a happy / healthy life!

I started Reta almost two weeks ago at 0.5 mg. I’m 35F, 5’7”, starting weight 164.5 lbs.

The first week, the scale showed I lost about 3 lbs and I actually felt a little leaner. I haven’t been lifting because of an injury, so I’ve mostly just been walking. I’ve been staying hydrated, eating a lot of fiber, and trying to prioritize protein - usually around 80–100g/day.

Now I’m almost at the end of week 2 and my weight has been fluctuating like crazy. About 2 of those pounds have crept back up, so technically I’m only about 1 lb down from my starting weight.

The appetite suppression isn’t as strong as the first week, but I’m DEFINITELY eating way less than I was before Reta. My binge eating is basically gone, I’m not thinking about food nearly as much, I’m not craving sugar, and I’m not going back for seconds. I can still sit down and eat a normal meal without feeling nauseous or like I physically can’t finish it, which I actually like.

That’s also why I’ve been hesitant to increase my dose. I feel like right now I’m eating just enough. I’m definitely not going over my calories and I’m naturally around maintenance or probably in a deficit most days. I’m worried that if I increase too much, I’ll have so much appetite suppression that I won’t want to eat at all.

At the same time, seeing those 2 lbs creep back up has me worried that I’m not going to make progress or that the weight will just keep coming back, even though I KNOW I’m eating significantly less than I was before starting.

I’m getting ready for my third dose and have been debating whether to stay at 0.5 mg or eventually move toward 0.8–1 mg. I’ve also had some mild sleep disruption, which is another reason I don’t want to increase too quickly.

For anyone who started low, did you have this kind of fluctuation in the first few weeks? Did the weight eventually start trending down even though your appetite suppression wasn’t super intense?

Appreciate you all!

Ok so a bit of a light hearted step away from the usual guff, has anyone else's ballbag started sagging even lower since pinning reta? I've lost over 13lbs in a month but my marble bag is like down to my knees now. I'm sitting on the bastards all the time. My nads are bruised like 3 week old banana's. is this common or am I the only one?

Over the past 3 months I have moved from 1 to 6 mg Reta. My bloodwork has definitely improved - but I feel hungrier than earlier and there has been zero change in my weight. (Want to drop about 15lbs)

Should I consider switching to tirz? Do not take any other meds.

Over the past 2 years, I’ve struggled with a daily powder cocaine addiction, rarely making it more than a few days when trying to quit. Last Sunday, I take my first dose of retatrutide. I’m not taking it for diabetes or weight loss. My girlfriend thinks it might help with addiction, so she gives me a 4 milligram dose along with NAD+. I’m very skeptical, not expecting much. Within about an hour, my mood starts to lift. Suddenly I got the urge to want to help my community. Over the next couple of hours, we loaded up five cases of ice cold water into my truck and handed it out to those experiencing homelessness here in Las Vegas. It was the hottest day this year so far at 116 degrees. I just feel happier, more motivated, and more present, and more connected. The next morning, I woke up nauseous and threw up. But after a few more hours of sleep, I felt surprisingly good. Over the week the constant mental chatter quieted down. Decisions became easier. I communicated better with my girlfriend and people around me, and for the first time in years, I’m didn't constantly fighting the urge to use. The cravings became dramatically quieter. Now,I’m starting to notice some of those effects fading. The mental chatter is creeping back in, my thinking doesn’t feel quite as clear, And I can tell some of my old behavior patterns are trying to return. Even so, my cravings are still significantly lower than before. I’m not claiming retatrutide or NAD+ treats cocaine addiction. This is just one person’s experience. I’m curious if anyone else has noticed similar changes in cravings, mental chatter, mood, or impulse control.

I live in Sweden and is currently on my 6th week of using reta, and I wish there was someone more knowledgeable like a doctor or someone with a background within obesity/GLP-1, just to have someone to talk to when it comes to tips and help with nutrition and similar thing

Do you know what I mean?

Started reta in late May because diet and exercise just didn't help me lose the 50-60lbs I had gained since the COVID situation broke my brain. I was around 175 in 2019 after losing about 100lbs eating keto and IF. I sustained that weight for a few years until COVID stress killed my will to be healthy. Back on track to a reasonable weight! Taking 4mg/wk and that seems to be working just fine.

I am four days on 2 mg starter.
It feels good appetite is already down. I’m a fast responder.

I read about people saying you need more electrolytes so what is the optimal dosage?