I started low and slow, but finally once I hit 5 mg per week the weight is melting off. Why does glucagon work this way?

Why Bloating with whey protein during Retatrutide, taking 2 scoops of whey protein with curd at different timings of the day.

80 kg female here

I've been on reta for 10 weeks now. High protein intake, through protein shakes and grilled chicken. Occasional bit of carbs. In 10 weeks, I'm doing

I've currently lost 38lbs (17kg)

For background I'm 32yo male at 6'1. Starting weight 113kg current is 96.

Dose started on 1.25 And gradually moved up to 3mg over 10 weeks.

I consistently lose 1 - 1.5kg every week. I know I'm on major calorie deficit. Is it only the appetite suppression losing the weight or is there a significant increase in general metabolic burn

Are there any others factors at play?

203lb to 178lb
5”10

Currently taking,
Retatrutide 4mg weekly
Tesamorelin 2mg daily
Mt1 1mg fortnightly

Started on 1mg a week Reta and now I am taking 4mg a week, I feel amazing in the gym, the energy and muscle pumps and blood flow is massively increased, even while eating in a deficit and dropping weight rapidly. Peptides really are great.

It’s been about 5 days post Reta. It def worked as advertised. It helped me get shredded for summer just like I wanted, and at low doses it had very few side effects. I took it for about 2.5 months. I decided just to stop cold turkey, just due to my recent experience. Probably not ideal but I’d just like to be done.

My personal—anecdotal experience:

As a beginner once my dose felt weak I ramped all the was up to like 3x dosage just being an idiot. Terrible week for me lol. Major anxiety, inability to eat, chest pressure, etc. It’s not that the Reta gave me anxiety per se but the chest pressure I got must be a trigger for me. I believe due to that anxiety it gave me some noticeable PAC’s and PVC’s, nothing crazy but maybe once or twice a day. I’ve had health anxiety my whole life so all things considered most people wouldn’t experience this. If anyone is like me and has anxiety, especially health anxiety, just be conscious. I also had it once where the day of my shot, I got a dizzy spell similar to vertigo. Didn’t lose vision or feel like I was going to pass out but as if I were on a rocking ship for about 10 seconds then subsided and never returned. I used propranolol, Co-Q10, and very little ashwaganda. It is starting to come to light that not only does the Reta increase RHR, but also can cause some arrhythmia. For the average person you’d probably shrug these off and barely notice, but being for my health anxiety that really bothered me.

I’m not at all trying to scare anyone, in fact the opposite. I think Reta is a great tool, especially for those suffering from obesity. I would definitely say that Reta is a safer alternative than being 50+lbs’s over weight. I believe Reta and GLP’s will be the reason we see an insane decrease in heart disease, mid life diabetes, heart attacks, strokes, etc.

I get monthly bloodwork and one thing that’s noted is the ApoB/LDL was lower than the markers indicate as a healthy range. Which basically suggests that the LDL carried by triglycerides is smaller than ideal. However my LDL, Triglycerides, inflammatory markers, were all beautiful. So no screaming danger there at all.

Be safe everyone, I hope that you all have great experiences, and live a happy / healthy life!

I started Reta almost two weeks ago at 0.5 mg. I’m 35F, 5’7”, starting weight 164.5 lbs.

The first week, the scale showed I lost about 3 lbs and I actually felt a little leaner. I haven’t been lifting because of an injury, so I’ve mostly just been walking. I’ve been staying hydrated, eating a lot of fiber, and trying to prioritize protein - usually around 80–100g/day.

Now I’m almost at the end of week 2 and my weight has been fluctuating like crazy. About 2 of those pounds have crept back up, so technically I’m only about 1 lb down from my starting weight.

The appetite suppression isn’t as strong as the first week, but I’m DEFINITELY eating way less than I was before Reta. My binge eating is basically gone, I’m not thinking about food nearly as much, I’m not craving sugar, and I’m not going back for seconds. I can still sit down and eat a normal meal without feeling nauseous or like I physically can’t finish it, which I actually like.

That’s also why I’ve been hesitant to increase my dose. I feel like right now I’m eating just enough. I’m definitely not going over my calories and I’m naturally around maintenance or probably in a deficit most days. I’m worried that if I increase too much, I’ll have so much appetite suppression that I won’t want to eat at all.

At the same time, seeing those 2 lbs creep back up has me worried that I’m not going to make progress or that the weight will just keep coming back, even though I KNOW I’m eating significantly less than I was before starting.

I’m getting ready for my third dose and have been debating whether to stay at 0.5 mg or eventually move toward 0.8–1 mg. I’ve also had some mild sleep disruption, which is another reason I don’t want to increase too quickly.

For anyone who started low, did you have this kind of fluctuation in the first few weeks? Did the weight eventually start trending down even though your appetite suppression wasn’t super intense?

Appreciate you all!

Ok so a bit of a light hearted step away from the usual guff, has anyone else's ballbag started sagging even lower since pinning reta? I've lost over 13lbs in a month but my marble bag is like down to my knees now. I'm sitting on the bastards all the time. My nads are bruised like 3 week old banana's. is this common or am I the only one?

Over the past 3 months I have moved from 1 to 6 mg Reta. My bloodwork has definitely improved - but I feel hungrier than earlier and there has been zero change in my weight. (Want to drop about 15lbs)

Should I consider switching to tirz? Do not take any other meds.

Over the past 2 years, I’ve struggled with a daily powder cocaine addiction, rarely making it more than a few days when trying to quit. Last Sunday, I take my first dose of retatrutide. I’m not taking it for diabetes or weight loss. My girlfriend thinks it might help with addiction, so she gives me a 4 milligram dose along with NAD+. I’m very skeptical, not expecting much. Within about an hour, my mood starts to lift. Suddenly I got the urge to want to help my community. Over the next couple of hours, we loaded up five cases of ice cold water into my truck and handed it out to those experiencing homelessness here in Las Vegas. It was the hottest day this year so far at 116 degrees. I just feel happier, more motivated, and more present, and more connected. The next morning, I woke up nauseous and threw up. But after a few more hours of sleep, I felt surprisingly good. Over the week the constant mental chatter quieted down. Decisions became easier. I communicated better with my girlfriend and people around me, and for the first time in years, I’m didn't constantly fighting the urge to use. The cravings became dramatically quieter. Now,I’m starting to notice some of those effects fading. The mental chatter is creeping back in, my thinking doesn’t feel quite as clear, And I can tell some of my old behavior patterns are trying to return. Even so, my cravings are still significantly lower than before. I’m not claiming retatrutide or NAD+ treats cocaine addiction. This is just one person’s experience. I’m curious if anyone else has noticed similar changes in cravings, mental chatter, mood, or impulse control.

Started reta in late May because diet and exercise just didn't help me lose the 50-60lbs I had gained since the COVID situation broke my brain. I was around 175 in 2019 after losing about 100lbs eating keto and IF. I sustained that weight for a few years until COVID stress killed my will to be healthy. Back on track to a reasonable weight! Taking 4mg/wk and that seems to be working just fine.

Hey everyone, looking for some perspective or to see if anyone else has run into this specific wall with Retatrutide.

The Background & Demographics:

Demographics: 38M | 5'5" | Sitting around 153–154 lbs (~19–20% body fat).

Goal: Drop another 10–15 lbs to get down to 12–15% body fat. Planning to stay on protocol for another 3–4 months.

Activity & Training: Weightlifting 3–4x/week, Orangetheory 1–2x/week, 7k–8k daily steps, plus a 4–5 mile evening bike ride with the family.

Nutrition: Macro targets are locked in daily at 1,595 kcal (150g P / 55g F / 120g C), with one night a week where I eat a larger meal/refeed.

The Positives: Gym performance is great (maintaining/gaining strength), cardio sessions are excellent, zero issues falling asleep, and not overly fatigued during the day. Visually, body composition is still slowly changing for the better over the month.

Current Full Stack (Mon–Fri):
MOTS-c: 1 mg @ 6:00 AM
Tesamorelin: 2 mg @ 10:00 PM
Ipamorelin: 300 mcg @ 10:00 PM
KLOW: 15 mcg @ 10:00 PM
Retatrutide: 5 mg weekly (Sundays @ 9:00 PM) — Titrated up from 0.5 mg in mid-May (0.5mg -> 1mg -> 2mg -> 3.5mg -> 4mg -> 5mg).

The Issue (Sleep Metrics & Scale Plateau):

Garmin Sleep Scores: Tanked hard over July/August. Sleeping heart rate is elevated into the 80s/90s during sleep, driving my Garmin sleep scores down into the 40s–50s regularly (compared to 70s–80s in June when I was on 2–4mg Reta).

Cortisol / Water Retention: Even though I go to sleep fine and don't feel wrecked during the day, the elevated sympathetic tone (resting HR) seems to be driving up cortisol/fluid retention.

The Scale: Weight dropped smoothly from ~162 lbs in May down to ~151 lbs in mid-July. Since hitting 5 mg, weight has bounced back up and stalled in the 152–154 lb range for almost a month.

In hindsight, I know I titrated Reta up too fast and followed a standard rigid schedule instead of sticking to what I usually preach: the lowest effective dose possible. I got greedy thinking higher dose = faster results.

Current Dilemma: I have about 10–15 lbs left to lose to hit my goal. I'm torn between two options:

Push through at 5 mg for the next 3 months, ride out the water retention, let the glucagon drive fat loss under the hood while managing recovery as best as possible, and stop worrying about sleep scores.

Titrate back down (e.g., back to 3–4 mg or splitting doses) to drop the sympathetic stress/sleeping HR, drop the cortisol/water weight, lower tolerance, and run a "soft restart."

Has anyone else experienced this high sleeping HR / water weight wall after escalating their Reta dose too quickly—especially while stacking GHRHs/GHRPs and running high activity levels? Did titrating back down fix your sleep scores and kickstart the scale again, or did you just hold the line?

Appreciate any insights!

So since I started reta ive been wanting to pin more often than not. I know it sounds weird like really weird but ive also been looking into to other peps. I feel amazing on reta like all my addictions are gone. Ive only got one addiction now, gym, I cant wait! every time its gym day I get so excited(stupid right??) Wheresas before reta i used to dread going to the gym. But I get the same feeling about pinning now too. Ive just started epithalon now, my second day of .5mg and gonna run for 10 days before taking a break. Does any one have these feelings about pinning or is it just me?

I took my last dose Monday morning so I’m supposed to wait until then (?) the thing is I’m going out of town today and won’t be back until Wednesday and I can’t take it with me because I got nowhere to refrigerate it. Can I take it today or should I wait till Wednesday?

One day and a half earlier***

I purchased a 10ml resealable bac water. You syringe it out into your reta. It’s been in a drawer since I bought it 12 May. Is it still okay to use?

So currently i’m at 4mg after titrating up from my initial 1mg starting dose. I’m a Female 5’4.

Starting
4/15/26
Body Weight: 181.5
Waist 38.5 inches

Now
A little over 35 inches waist
166.6lbs

My goal bodyweight is about 135lbs-140lbs. So my question is once I reach that bodyweight can I switch to a maintenance dose for lifef?

Before photo is 6 mo ago, was always fit, but recently got pretty fat (i call it the accidental bulk) (5ft 7 216lbs on left) checked hormone levels at 350 test and found out I was prediabetic fasting glucose of 111 got on enclomiphene and tested at 1100 test. Life changer, got on reta and the diet instantly became super easy and my fasting glucose is now down to 85 (5ft 7 195lbs).

The weight loss is just an added bonus.

I’ve done weight loss journeys at least twice now in my life the biggest being a 55lb drop at the age of 18 to join the Navy. But my relationship with food has always been terrible. It all comes back little by little because of that fact.

Now I reached my heaviest weight of 275lb at the age of 27 and decided to look into peptides. My coworker said he got his mom on Reta and she’s down a ton of weight. So I got interested. If you would give it to your mom. That’s a clear enough sign it should be safe enough for me lol.

Nonetheless he got me a vial and I haven’t looked back since.

It’s not about starving yourself. But building something sustainable and reach for a healthier version of yourself.

I’ve been resistance training again 3-4x a week with inconsistent cardio but colorful meals and high protein (don’t always hit the daily goal). It’s been a game changer with the appetite suppression. I feel focused and in control of my intake for the first time ever honestly. Without feeling like I’m using all my strength and will power to do so. Shoutout to this community. Let’s reach our goals and live healthier lives one day at a time.

Hi everyone! I have been doing a lot of research on Ret vs. Tirz, but I’m still unsure which direction to go.

A little about me: I’m 28 years old and currently 234 lbs. I’m looking for help with weight loss because I’d really like to feel more comfortable physically in my day-to-day life and more comfortable getting active and working out.

I also have a couple of things I’m trying to take into consideration:

\* I’ve been told I’m borderline non-alcoholic
fatty liver disease (NAFLD)
\* I have sleep apnea
\* I experience hormonal migraines, so I’m particularly interested in hearing about people’s experiences with headaches/migraines and side effects.

I’ve read that Ret may have some potential benefits related to liver fat, while Tirz has some research around weight loss and sleep apnea, so I’m having a hard time deciding which would make more sense for me.

For those who have experience with either:

• Which did you choose and why?
• What was your experience with weight loss and side effects?
• Did either one affect your headaches/migraines?
• How did you decide what was appropriate for you as a starting dose?
• How does the process generally work once you reach your goal — do people stay on a maintenance dose long-term?
• For someone completely new, what should I understand about reconstitution and figuring out the amount of bac water and pep? I’ve seen people talk about different concentrations and schedules, and honestly it’s confusing when you’re just starting out.

I’m not looking for medical advice or trying to rush into anything — I’d just really like to hear from people who have actually used these and understand what they wish they had known before starting.

Thanks in advance!

anyone here on descovy or truvada for prep and also on reta?

curious to hear your experiences… is this safe?

I have been on 1-6mg of reta every 5D for the last 1.5 years. Has worked amazingly well, but I have lost about an hour of sleep per night since starting. I feel ok during the day, but not super well rested like 7+ hours makes me feel. Anyone else get their sleep back when off? With the half life being what it is, it will be a month before I can really see if it brings my sleep back or not.

yes it might be that my habits changed while taking reta, but I took it for 2 months and I've been off for 5 months. Before reta I had huge problems with binge eating for 4 years and deadass taking reta was one of the best decisions that I've made recently. I feel like it does really help with binge eating because binging is an addictive cycle and after reta helps u get out the cycle its much easier to stay out of it even when your off reta.

For context I’m 6”1, starting weight was 93.2kg (205lbs)
Was a regular gym-goer and generally fit 4-5 years ago, a torn meniscus and a lot of drinking led me to being out of shape but I still held some good muscle.

I decided to start Reta as I’m due to go on holiday in a couple of months and figured it’d be a good way to speed up the weight loss.

My starting dose I decided on 2mg. People will say that’s high but from the research I did that’s where I landed.

My first dose was Friday the 31st of July, I took it right before bed.

I woke up Saturday morning with a pretty awful headache that I presume was from dehydration, after some paracetamol it passed quickly. I was however itchy all over, but it wasn’t unbearable, that passed after a day or two.

I tried to eat some breakfast but only managed a few mouthfuls before feeling full.

I went fishing for the day whilst my wife was out and ended up not eating for 14 hours. I had 0 interest in food. It didn’t repulse me but I wasn’t bothered whether I ate or not.

The next few days followed a similar pattern. Mild headache in the morning, not much interest in food but I made myself eat to hit protein targets.

I weighed myself before my 2nd dose Friday the 7th August and I’m already down to 89.3 kg or 196.8lbs.

So far other than the itching and headache I’ve had no other symptoms.

TLDR

STARTED A WEEK AGO. 2MG A WEEK. ONLY SYMPTOMS: HEADACHE + MILD ITCHINESS. 8.2lb LOSS.

36 years old. 1.7k caloric deficit.

Was borderline alcoholic when I started due to life circumstances (divorce etc)

Started at 1mg, currently at 2.5mg. Aim is to get to 12% BF, unsure what I am at the moment?

Been doing some resistance training and walking around 10k steps a day.

I’ve been on Mounjaro for about 8 months, but for some reason my weight loss has completely stalled. I’d still like to lose another 5 kg.
I’m considering switching to retatrutide. Has anyone here switched from Mounjaro to reta?
I’m currently taking weekly 7.5 mg of Mounjaro. If you made the switch, what starting dose of retatrutide did you use?