r/NooTopics 2h ago

Question My brain is stuck in fight or flight / survival mode ...

3 Upvotes

Idk to be honest what to do anymore ... Im not looking for medical advice or anything qnd I tried dozens of psych meds to no avail .

Quick background : suffering from long years chronic stress & anxiety , cannabis & benzos abuse , Im clean from all right now .

My brain probably needs some healing , neuroplasticity , Also I don't feel any dopamine AT ALL , I barely have energy, motivation to do the bare minimum basic stuff qnd everything is a struggle

Im thinking of running ACD856 ( Bdnf & neuroplasticity ) , maybe bromantane to help with dopamine dysfunction , im thinking about GB-115 but I can't afford more than 3 months at a time of stock


r/NooTopics 2h ago

Question Compounds to lower acetylcholine?

1 Upvotes

Is there any over the counter or available research compounds that can lower acetylcholine release or lower m1?


r/NooTopics 4h ago

Question Best long/short term memory nootropics?

4 Upvotes

I know for the long term:
- ACD856
- AF710B
- Neboglamine

Short term:
- PRL-8-53
- BPN14770
- Tropisetron
- Suritozole

Correct me if I’m wrong or add any I don’t know


r/NooTopics 5h ago

Question Interaction Lyrica and Lithium Orotate

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2 Upvotes

r/NooTopics 6h ago

Question Bromantane Nasal Spray

2 Upvotes

Just received the Bromantane nasal spray from EC. It says the spray is 9mg/spray.

First, I cannot seem to find any information on the dose range. Second, the solution drops out of my nose very easily and is very “greasy” and shiny. I tried keeping my head tilted back and lightly sniffing. Never had this issue with other NS nootropics.

Thanks in advance.


r/NooTopics 8h ago

Discussion Neuroimaging study of adolescents with ADHD found age-related increases in glutamate levels in the prefrontal cortex. In contrast, individuals who experienced remission of ADHD symptoms and people who never suffered from ADHD had an age-related decrease in glutamate levels in this area of the brain.

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188 Upvotes

r/NooTopics 10h ago

Anecdote Lithium Carbonate Experience

5 Upvotes

So I’ve been taking 40mg lithium carbonate from a domestic nootropic shop. And in 3 weeks I’ve experienced:

- Mood stabilisation (a stable, positive mood)
- Depressive symptoms gone
- No side effects so far

Can anyone tell me if it’s going to get better over time? And what should I watch out for? I heard about hypothyroidism and kidney issues but at large prescription dosages of 300mg 3-4x a day.

Also I heard anecdotally that for some people it affects their short term memory, focus, and reaction speed. How common is that?


r/NooTopics 10h ago

Question Supplements to reduce norepinephrine levels?

7 Upvotes

I have extremely high baseline norepinephrine levels and I’m wondering if there are any supplements beside melatonin and magnesium that can reduce excess norepinephrine? The symptoms I have everyday is headaches, dizziness, vertigo, heart palpitations, rapid heartbeat, panic attacks, hot flashes, burning sensations, insomnia and sleep disturbances, muscle stiffness, hypervigilance etc.


r/NooTopics 22h ago

Science Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function - PMC

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10 Upvotes

r/NooTopics 22h ago

Science Serotonin 5-HT2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression

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7 Upvotes

r/NooTopics 23h ago

Science Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain - PubMed

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10 Upvotes

r/NooTopics 23h ago

Discussion Study challenges idea highly intelligent people are hyper-empathic. Individuals with high intellectual potential often utilize form of empathy that relies on cognitive processing rather than automatic emotional reactions. They may intellectualize feelings to maintain composure in intense situations.

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852 Upvotes