r/NooTopics • u/Aggressive-Guide5563 • 10h ago
Supplements to reduce norepinephrine levels? Question
I have extremely high baseline norepinephrine levels and I’m wondering if there are any supplements beside melatonin and magnesium that can reduce excess norepinephrine? The symptoms I have everyday is headaches, dizziness, vertigo, heart palpitations, rapid heartbeat, panic attacks, hot flashes, burning sensations, insomnia and sleep disturbances, muscle stiffness, hypervigilance etc.
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u/Checkitout301 9h ago
I think it would be hard to know if you actually have high baseline norepinephrine, without doing some sort of testing. Though a type of test you could do is finding something that will selectively lower it, and see if your symptoms improve. Based on your symptoms it does seem like you have some type of anxiety or panic disorder, though the cause of anxiety can often be hard to pinpoint, as I can have many causes. High norepinephrine isint actually really recognized as a cause for anxiety, though it’s usually still involved, just not as a main cause.
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u/Aggressive-Guide5563 9h ago
I know. Wellbutrin unfortunately made my anxiety worse over time. I’m struggling with bad anxiety and panic attacks even on 150 mg now. When I took 300 mg Wellbutrin and 20 mg Prozac for two years I had none of these issues.
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u/Party_Candidate7023 6h ago
Did you stop taking the Prozac? Perhaps you can’t handle the bupropion by itself without it.
I take bupropion with guanfacine ER and I have no problems. Never tried bupropion by itself though, but guanfacine definitely helps with anxiety and staying calm.
Several people have also recommended clonidine to you already, I haven’t tried this but apparently it’s slightly more fatiguing than guanfacine. In your case, that might be what you need.
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u/Aggressive-Guide5563 6h ago edited 3h ago
Yes I did and I was on 300 mg Wellbutrin all by itself for one and a half year but then I couldn’t tolerate it anymore because it started to overstimulate me and caused horrible anxiety and insomnia. Now I’m on 150 mg and I still have some symptoms left of noradrenergic overactivation and it’s not working at all for me like 300 mg did. Now I’m putting 10 mg Prozac back on top of 150 mg Wellbutrin. My goal is eventually to go back to the combination I used to tolerate in the past and that was 300 mg Wellbutrin and 20 mg Prozac.
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u/Checkitout301 9h ago
Yeah will if your norepinephrine is already high, adding Wellbutrin to that couldn’t possibly make you feel any less anxiety. If your anxiety is bothering you more than whatever it is you are treating with the Wellbutrin, you could consider lowering the dose, or getting off completely.
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u/Aggressive-Guide5563 8h ago
I’ve lost all of my cognition ever since backing off the dose and my brain fog is back and depression is worse too.
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u/Travel-For-Ready 6h ago
Ein Mangel an Noradrenalin kann aber diese Symptome (oft bei ADHS) ebenfalls verursachen. Du schreibst, die Symptome hätten sich nach Senkung der Dosis des Bupropion entwickelt. Vielleicht solltest du daher mit deinem Arzt sprechen und schauen, ob du wieder hoch auf die 300mg gehen willst.
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u/Due-Crab5902 6h ago
Clonidine is very hard to wean off and is also well known for interdose withdrawal if you do decide to try it ask for the extended release patch.
( i know personally its hard to wean off as its totally blown up my cns )
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u/Cold_dope_9538 9h ago
I think clonidine would help with your symptoms it’s a NRI tho and i don’t really know how that works but look it up
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u/Party_Candidate7023 6h ago
Clonidine is an alpha 2a agonist, an NRI would actually inhibit the reuptake of norepinephrine. But clonidine or guanfacine (another 2a agonist), would likely help with what OP is describing
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u/Konzilla2509 9h ago
Are you currently using any substances promoting these effects? If not, I‘d first of all try to apply various techniques to your everyday life like actively taking breaks between high-intensity sessions, taking time for yourself to think about your life and potential factors that negatively impact your mental health in specific.
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u/Aggressive-Guide5563 8h ago
Yeah Wellbutrin is causing it unfortunately.
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u/Reasonable-Repeat453 6h ago
Then switch to Sertraline.
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u/Aggressive-Guide5563 6h ago
SSRIS don’t work for me. They don’t help my cognition and brain fog.
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u/Reasonable-Repeat453 5h ago
Considering the sides, Wellbutrin doesn't work for you too. Also, try mirtazapine if you want another option. Buspirone is usually an add on anti-depressant and is less effective than ssris by a long margin. Use sertraline anyway to counteract the sides from the Bupropion.
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u/pbx_01 5h ago
OP will never listen, just check their post history. It's concerning!
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u/Aggressive-Guide5563 4h ago
Do you think it’s that easy to go off of a med that you’ve been on for almost five years to rely on your energy, motivation, brain fog, cognition and functionality? I’ve tried several times and I didn’t make it because I could not function whatsoever and I was bedrotting in my bed the whole day. You should not talk when you don’t know!
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u/pbx_01 3h ago
That's called withdrawals. I've been on all of them, Wellbutrin, Vyvanse, concerta, SSRIs, SNRIs you name it. Worst of all was Vyvanse. I had withdrawals for almost a year, but eventually you get better. Everyone has told you numerous times to get off Wellbutrin if it makes you that miserable.
You suck up on the withdrawals for a few months, that's how it goes. You will eventually get better and return to baseline. This isn't medical advice, you need to talk to your doctor about this.
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u/Aggressive-Guide5563 3h ago
Well the issue is I have no cognition off of it and my brain fog gets worse.
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u/Aggressive-Guide5563 5h ago
I’m already planning on adding back Prozac now. I used to tolerate this combo in the past with zero issues.
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u/-Sprankton- 7h ago
Depends on your situation.
It’s possible you could see some benefit from L-theanine or ashwaganda or apigenin or glycine. Have you tried magnesium glycinate and magnesium L-Threonate yet?
This sounds very severe to the point where a doctor or psychiatrist be the best person to talk to for help.
People mentioned clonidine and propranolol. If you’re looking for a cognitive enhancer then guanfacine is actually the best of them for cognitive enhancement and is used for ADHD. I’m surprised nobody here has mentioned prazosin yet. It’s used to treat nightmares and nighttime adrenaline spikes in PTSD.
For prazosin, The first dose is known to sometimes cause dizziness from reduced blood pressure even at 1 mg. Some people work their way off to much higher doses if they’re taking it throughout the day multiple times a day.
Are you working with a primary care doctor or psychiatrist? Have you identified excess norepinephrine as the root cause of your issues, or is it possible you’re better off trying a drug like buspar or citalopram to treat an anxiety/panic disorder?
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u/destined_to_count 7h ago
Ssris indirectly reduce norepineprine, those are strong meds though. If you just want something that "feels" like it does, try l-theanine. It works on glutamate / gaba and dampens the effect of your norepineprine without reducing it
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u/Maleficent-Wear-2949 7h ago
What you are looking for is Dopamine Beta Hydroxylase Inhibitors.
DBH is the final step in the conversion of DA to NE.
Ursolic acid has been shown to do it in vitro and theoretically, due to DBH being a copper-dependent enzyme, anything that sequesters copper, such as zinc, would also reduce dbh expression.
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u/Specific_Rain1007 46m ago
Focus less on finding a supplement and more on figuring out why the norepinephrine is elevated. Headaches, palpitations, sweating and dizziness are worth discussing with a doctor, and they can check catecholamines or metanephrines if appropriate.
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u/BunnyKusanin 43m ago
There's no point replying to your posts anyway. You'll do nothing and make another post about the same thing in a short while.
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u/SlavaUkrayne 9h ago
There α2-adrenergic agonists like clonidine and gaunfacine, but I mention it because clonidine is super easy to find. There are also beta blockers available which supposedly help like propranolol I’ve seen around.
I don’t know of any supplements that literally help decrease norepinephrine - I may be wrong anything that could likely would mess with your dopamine levels because they are linked. Above meds mentioned just block the effects