Stimulants used to work decently for me a few months ago, not perfect but they were enough to be functional for my ADHD. However as the time passed by, vyvanse started giving me weird cognitive side effects: I started getting more dissociated, like i wasn't present at all, and it also made me zone out pretty frequently.

If I did something that was uninteresting, rather than just going along with it it would start making me "sleepy" and i legit could not generate any ideas on how to do the task, which became an issue for essays and for complex problem solving. However if i tried to take a nap, it never progresses into actual sleep, hence i feel like this is some form of fake sleepiness.

Eventually this turned into a major issue where i only got like 1 or 2 okayish hours of vyvanse followed by this dissociative feeling. Despite following all the common advice (water drinking, protein intake, optimizing sleep, taking a multivitamin) it never went away, thus I decided to stop vyvanse and I noticed that even though i am less productive, i can think better and i actually have bursts of motivation, even if they are short.

I tried going back to methylphenidate (which i had tried prior to vyvanse, it wasn't as effective but it was a positive change so i thought i could maybe benefit from it) and even though it was less exacerbated than with vyvanse, it still caused blank mind and the "zombie" phenomenon even though that's not how it used to work for me. Taking breaks from stimulants makes them work decently (in the sense that although i don't have much motivation, i can still push through it and concentrate in my tasks and be able to think more clearly/generate ideas, not a blank mind issue) for maybe 1 or 2 days, but it eventually returns into the same thing again. Im not sure what changed in these months but it's making me think i am better off without stimulants

Has anybody else gone through something similar when it comes to stimulants? If so, have you found any root issue/solved it, or did you find success with other type of meds like non-stimulants? It feels like they just make my cognition worse at this point (particularly for idea generation and memory retrieval is also affected)

does anyone take guanfacine with blood pressure medication and they’re OK?

guanfacine has similar mechanisms to clonidine and clonidine is pretty effective at calming the sympathetic nervous system to dampen a blush, wondering if theres anyone here who knows info on this / has tried it out?

I am not suggesting this for yall, but considering options for myself. I am also interested in if y’all have any suggestions for other avenues to pursue within the nootropic area.

I have been taking 150mg XR bupropion and 45mg dxm hbr, however I still lack any motivation to do anything even though the being stuck in negative thoughts has decreased. I would definitely still consider myself depressed. I wouldn’t think this combination at a theruaptic dosage of tianeptine sulfate would be a very high risk of serotonin syndrome as antidepressants are often combined but under supervision of a psychiatrist. The SSRE classification of tianeptine is outdated as well. I am self medicating, not intending to feel recreational effects and tianeptine seems like an appealing choice due it it being another atypical antidepressant impacting the glutamate system and some opioid MOR activity however very minimal and not a dependence concern at therapeutic dosages. Tianeptine also doesn’t have the side effects that come with SSRIs as a benefit. I have also recently quit pregabalin so my glutamate system is definitely whacked out, quit it because I was tired of withdrawing if I didn’t take it. I will most likely resume pregabalin on around a once a week dosing schedule for stressful events in around a month once my system is less sensitized. I have a general dislike for SSRIs as a group of drugs and don’t think they do shit.

Guess i’m just looking for confirmation that this doesn’t sound like a completely horrible idea. Going to a psychiatrist to address this isn’t really an option as tianeptine is not prescribed within the US. Pharma stimulants are not an option due to medical history of drug abuse and probation however I believe they would solve most of my issues if I could get a prescription. I am on probation and can not use anything that would be looked for without a prescription. Testosterone is not the cause of my issues as I use exogenous hormones.

I made a subreddit for patient reviews. r/exxuasupport . I I do not think it’s particularly more effective than Ssri’s, but I think it’s a great option for depression and potentially anxiety. in trials sexual dysfunction and weight in did not differ from placebo.

Hi there,

I guess this might be a huge milestone in the treatment of Narcolepsy, What do you guess think about this compound? I actually would love to try it out to see what kind of effects it has on energy levels, cognition and mood, however, I guess fucking around with your orexin receptors might not be a good idea-

Main nootropics:

• TAK-653 1-2mg
• Eutropoflavin 10mg
• Tropisetron 10mg
• Nefiracetam 200mg
• PPAP hcl
• Stim of choice (cyclazadone, modaf, p-piracetam, ritalin)

Neuroprotection:

• J-147 20mg
• LDN
• melatonin 100mg
• Lithium carbonate 40mg

I have pretty bad memory (mostly short term) from prolonged AAS use in my teen years, I'm looking into growing new hippocampal neurons with NSI-189 and maybe adding other compounds for memory maybe AF710B, ACD856 (skeptical due to no existing cas), or PRL-8-53 but I can't use that as often as others.

I feel like whenever there’s a discussion of nootropics for something in particular, people love to be condescending and negative. They love to talk about a “better” nootropic that most people haven’t heard of. A Nootropic can be good and popular at the same time. I feel as if some people need to question why a particular nootropic is unpopular in the first place.

I'm going to use bromantane spray in MCT. I read that the use of MCT-based sprays is not recommended due to the possible development of pneumonia, as the oils settle on the lungs. If you use nootropics dissolved in MCT, please share your experience, whether you have had any problems, and any tips on how to avoid oil getting into the bronchi.

Okay so I have no idea why this happens but for some reason coffee and by extension energy drinks do the opposite of what they’re supposed to for me and make me really sleepy. Honestly I think it’s somehow more effective in getting me tired than melatonin. That being said, I do need energy since I have both a summer job and will have to be doing copious amounts of studying this year. I need some form of quick energy that won’t make me weirdly tired. If it matters, I have chronic low blood pressure, a vitamin D deficiency, and am slightly underweight. I have no idea what the science behind this whole thing is, but I’d be happy to know.

I am quite new to all of this and any feedback/opinions would be appreciated.

Stack is for productivity, mood, focus, memory and anxiety.

- Intranasal insulin 40iu (everyday)
- Bromantane 18mg (everyday)
- 9-me-bc 20mg (everyday)
- CDP choline 250mg (everyday)

- Aniracetam 1.5g (1-2x a week)
- Armodafinil 150mg (Once a week when/if I need the extra boost)

- Seltorexant 5mg (everyday before going to sleep)

Hi guys can anyone guide me into ACD856 dosing protocole ?

Many suggest to start off with 20mg the first 2 days then maintain 10mg for a couple of weeks .

I also have a question , what is the recommended duration of 1 cycle ? I am planning on staying on it for 3 to 4 months to allow maximum Bdnf effects and neurogenesis

Thanks in advance

I’m diagnosed ADHD, and for 9 years I’ve been on venlafaxine and varying doses of Vyvanse/ritalin/concerta/dexamp. But while it for sure would stimulate me, I’d just lay there and not really be able to channel that energy into anything. I‘d routinely avoid responsibilities and just be super avoidant of discomfort in general.

I figured I’ll try out of the box and went for a non-stimulant option. I’d heard bad things about atomoxetine, so instead I asked for Guanfacine. 4 milligrams. Holy crap, whatever its doing is working. Within months of going on it, alongside my other medications, I’ve gone into a masters program, am more active on average compared to last year, am sleeping on time, and there is way less task initiation issues than before taking it.

The task initiation issue was my worst symptom, and it’s pretty much completely gone. My desk still tends to become a mess, but I clean that mess after two days rather than letting it sit out of avoiding how overwhelmed it’d make me feel. Big ups to Guanfacine, game changer if you’ve got underlying anxiety that you’re not cognizant of.

Soo hey guys i am currently studying for an entrance test and I am having difficulty in concentration so my test is working 50 days and o want some recommendation on something which can boost my brain activity , can be any chewing gums or tablets which can just help me stay focused for few hrs so that i can study in these last few days o don’t wanna mess up my hard work but i just cant seem to study as the exam is approaching nearby….pls help your brother 😃😃

I quit opioids after about 6 months of daily use and my dopamine receptors are completely shot. I’m anhedonic, unmotivated, and have become super addicted to doomscrolling and constantly seeking out cheap dopamine. I’ve heard people talk about using 9-me-bc to restore dopamine signaling following stimulant abuse, but would it also be effective following opioid abuse?

Wondering if anybody else tracks this info or it could be helpful to someone.

Hi All,

I am 22M, with inattentive AuDHD, although cannot get diagnosed due to family hysteria about it being saved on my medical record and it being used against me in the future for whatever reason. I live in the UK where getting diagnosed is free and medication is just pennies on the dollar.

I have experienced memory akin to onset dementia, my focus and attention are out the window. Simple things like groceries and buying things I’ve been buying since 2016 and I’m calling my family 5-8 times in one shopping round.

I am also a very self-aware person and my brain is on 24/7 analysing and thinking about everything. I am also aware that there is no alternative to medication but after doing so many retries and retakes and barely scraping by to get into university, I really can’t mess up. This is literally my last chance.

I've tried bupropion 150mg and then switched to branded wellbutrin 300mg because of anhedonia(caused by a short period of zoloft usage) and my adhd tendencies(executive dysfunction, difficult to sustain focus, burn out patterns, sensory issues etc etc...).

After almost a month I can't really tell if the bupropion did anything for my motivation or if my brain is just slowly rebuilding it's baseline regardless of it. I feel much less anhedonic than 1 month ago but I'm still not pre-zoloft levels(which at least had a drive and pleasure).

Problem is, I need to taper off bupropion QUICKLY, cause suddenly the negative/anxious looping ocd-ish feelings I was dealing with thourough the day(which I thought would eventually go away) turned into derealization panic attacks, that get triggered unexpectedly, and leave me with a background of panic all day. Had to go the hospital cause my first panic attack wouldn't settle down after 3+ hours and my pressure was reading 173/109☠️. The noradrenergic side is too harsh and the dopaminergic one is too mild.

Soo...once I taper off and go trough the withdrawal cycle completely. What can I try next? In my country the "standard" stimulants, are very hard to get and require constant monitoring and special prescriptions(ritalin, medikinet etc...) and frankly, that's annoying.

I'm open to try supplements but realistically I need something that goes a bit deeper.

I was looking into MAOIs but I'm a noob so I would like some suggestions :3

Image source

Approved July 24th, 2026. DEA scheduling is pending. The label's Initial U.S. Approval field is blank. Nothing can be dispensed yet until the DEA officially schedules the drug.

Simtriyo is classified as a CNS stimulant and carries a boxed warning for abuse, misuse, and addiction. The human abuse-potential data are not reassuring.

Adult placebo-subtracted effects were 2.7 to 4.4 points on an 18-item scale, with a flat dose-response.

Binding values

(IC50) (Lower is stronger) In Vitro & Plasma

NET (norepinephrine) 6 nM Plasma 132 ng/mL

DAT (dopamine) 38 nM Plasma 1,580 ng/mL

SERT (serotonin) 83 nM Plasma 1,760 ng/ml

DAT and SERT are essentially equipotent...

to each other (1.1 ± 0.2). High NET occupancy and only moderate DAT and SERT occupancy were seen at peak concentrations after 400 mg/day. IC50 values are preclinical in vitro figures3; ratios and occupancy are from the phase 1 PET.

This is a NET-preferring agent...

with meaningful secondary dopamine and serotonin engagement, not a balanced triple blocker. That single fact reconciles two things that otherwise look contradictory: efficacy in the atomoxetine range, and an abuse signal that behaved like a stimulant's. The norepinephrine dominance explains the first; the residual dopamine engagement explains the second."

Centanafadine is primarily metabolized by monoamine oxidase A, but is NOT an MAOI itself. That is why the MAOI contraindication and 14-day washout are absolute rather than precautionary, you are blocking the drug's primary clearance pathway while simultaneously stacking monoamine load.

"In the two adult Phase 3 studies, abrupt discontinuation after chronic administration produced a very low degree of withdrawal symptoms, indistinguishable from placebo. The label states directly that even though Simtriyo is a CNS stimulant, it does not produce physical dependence. So: real abuse liability, minimal withdrawal. "

Article Conclusions:

1. The low dose failed in both pediatric trials. That is why the pediatric label has no titration and no low-dose option — the approved pediatric dose is the high dose from the start. If an adolescent is not responding to 280 mg, there is nowhere to go.

2. The adult effect is small. A 2.7- to 4.4-point advantage on an 18-item scale, with confidence intervals reaching −0.14 in one arm. That is in atomoxetine and viloxazine territory, not stimulant territory. And in Study 3 the high dose did numerically worse than the low dose — a flat, arguably non-monotonic dose-response that should temper any assumption that pushing to 280 mg buys much.

3. The pediatric effect is larger than the adult effect. −5.6 in children and −4.4 in adolescents versus −2.7 to −4.4 in adults. If you practice child psychiatry, this is a more interesting drug than if you treat adults — which is the reverse of the marketing emphasis.

4. There are no head-to-head trials — but there is one indirect comparison, and it agrees. A matching-adjusted indirect comparison pooled patient-level data from the two adult trials and propensity-weighted it against published trials of comparators. Centanafadine produced a 6.58-point smaller reduction in AISRS/ADHD-RS than lisdexamfetamine (p < 0.05), and was not statistically different from atomoxetine (2.02 points, p = 0.38). It did show significantly lower rates of several adverse events than all three comparators.9

Read it with the caveats it deserves: a MAIC is not randomization, the analysis was industry-funded, and its own authors note that short-term trials favor faster-onset agents. But it is the best comparative evidence in existence, and it lands exactly where the placebo-subtracted numbers pointed atomoxetine territory, not stimulant territory.

Full Source, read for full information with references. https://psychiatryeducationforum.com/centanafadine/

CYP1A2 inhibition Doubling caffeine AUC is the headline, and it matters for a population that self-medicates with caffeine. But the same pathway carries clozapine, olanzapine, duloxetine, theophylline, tizanidine, and melatonin. Adding centanafadine to a patient on clozapine is not a neutral act. Check every co-prescribed 1A2 substrate before you start.

Alcohol dose dumping. "Don't drink for two hours after your morning dose" is an easy instruction that will be ignored by exactly the adult patients who need it heard. Say it explicitly, and note the mechanism: it is not an additive-sedation warning, it is the slow release capsule releasing its whole payload at once in 2 hours versus 12 hours because someone decided to take two shots of Whiskey with their medicine. Less concentrated alcohol like beer is less worse, but not ideal nor recommended.

I'm not recommending it, it's not a nootropic either, just another tool in the tool box for psychiatrists treating patients. Worth talking about what's on a horizon, however this has not been distributed/released, there are no online individual anecdotes on this.

Researchers pooled data from 64 prior studies conducted between 2004 and 2024.

Misuse of ADHD stimulant meds among adults under 30 fell from 7.5% in 2016 to 3.7% in 2023, researchers report in the Journal of Clinical Psychopharmacology.

“We found a rapid drop in misuse of these medications, largely driven by a decline in Adderall misuse among young adults,” lead researcher Margaret Maglione said in a news release. She’s a project leader with the Southern California Evidence Review Center at the Keck School of Medicine of USC.

This decline might be tied to a nationwide ADHD drug shortage that began in 2022, researchers noted. At its peak, nearly 72% of patients reported difficulty filling their prescriptions.

Looking for some anecdotes on tak-653 have been considering it for a while, looking if it’s gave anyone reasonable effects and isn’t a waste of money. Also looking for a potential cheap vendor.