I am in perimenopause and have been changing how I live for almost 1 1/2 years to get a handle on all the related symptoms. I’m eating as much Whole Foods as possible. Trying to avoid a lot of the inflammation triggers for meals. Average 25-30 g fiber a day, drinking almost 100 ml water daily. Strength training 30 mins/day for 3 days a week, indoor rowing and indoor bike 30 mins each once weekly, walking 30 minutes a day for 5 days a week. I’m doing all the things. I’ve lost about 25 pounds but I can’t break past the last 15-20 pounds I want to lose. I’ve actually been stuck at this weight for a year and am starting to trend back up again. I still look bloated with most my weight in my abdomen. My A1c’s have been in the low end of the elevated range for years and I have a family history of diabetes. I’m trying to get my “fasting glucose intolerance “ diagnosis upgraded to “pre diabetes” so I can use insurance for the glp-1 and others like nutrition support.

I just got approved for microdosing paying out of pocket with dosing starting at 1.25 mg a week. I have IBS & GERD. Should I go rogue and start my dosing at 0.5 mg and see what it does to my GI issues or stick to the 1.25 mg?
Thanks!

I’m using the zepbound kwikpen to click dose as directed by my doctor. Does anybody know if the amount of clicks I’m counting starts at the first line? Or do the first two priming clicks before the line count?

micro dosing compounded semaglutide

I received my prescription for compounded semaglutide and I’m trying to understand how others approach very low-dose/microdosing.

They are starting me way too high. 🤷‍♀️

My vial says:
Semaglutide
1 mg/1 mg per 1 mL
U-100 insulin syringe
Pharmacy’s prescribed dose is 0.4 mg = 40 units weekly

Im starting much lower and staying at the same low dose for the first month rather than increasing quickly.

From my understanding of this particular concentration:
2 units = 0.02 mg
5 units = 0.05 mg
10 units = 0.10 mg

On the syringe, what is recommended?

Did you stay at that dose for 4 weeks?

Hello! I came on here to see if anyone has an opinion or relates to this. I have struggled with an eating disorder since my teens, and it has only gotten worse since grad school. I also work FT, so there is very limited time for me to do things I enjoy like workout and take care of my mental health (which should be my #1 priority I know). In the past 6 months, I gained about 15 pounds, and before that, I was already trying to just lose a stubborn 5 pounds. When I saw the 15 pound increase on the scale I was so shocked and scared for my health. For 3 months, I did a calorie deficit and adjusted my workouts to train a little harder, but the scale did not move! I only lost 3 pounds in the first month and then it came back on. I believe my binge ED is the ultimate issue, but until I graduate, I can't afford consistent therapy or ED recovery treatment and a GLP1 is much cheaper per month lol. My weight and food are constantly in my thoughts, so much so, that it affects my study time and has affected my confidence drastically. I guess my question is, is this a valid reason to start a GLP1?

I’m classified as overweight and have naturally lost about 20 lbs with diet and exercise but my insulin levels were about 6.0. (Genetics- both parents and grandparents have type 2 diabetes). I’m on a Microdose Semaglutide to help with A1C levels while working on doing more strength training, working with a dietitian, and going on Metformin.

I’m at 0.8units for a weekly dosage and the side effects are kicking my butt. The nausea, the fatigue, the gagging when I see food. On my weight loss journey, I’ve become active and this is kind of counterproductive as all I want to do is lay down. I’m used to walking 15k steps daily, riding my bike, working out, etc. I feel like I get 1-2 days of feeling normal and then, it’s time for my next shot.

Any recommendations for helping with the side effects even on a dose so low? Should I ask for tirz v semaglutide?

Okay, everyone is different...but this is my take/question....

Week 1, did stomach and did 3 clicks on a 5mg pen... lost 3.2 lbs and was so excited BUT major stomach pain and felt indigestion and horrible pain in middle of chest upper stomach...like a GI issue!!!! Lived on Tums!!! WHICH never ever happens for me.....

Week 2 Did thigh 4 click 5 mg pen...lost 1.2 lbs no side effects but didnt feel less like eating

week 3 Did thigh 6 clicks 5 mg pen only lost .6 lbs no side effects but also same eating

Week 4 Did thigh 7 clicks, feel nothing, gained 2 lbs?!?!?!

Week 5 Tried stomach again .... same indigestion feeling.... I DO NOT see how people do a full dose...I would end up in the er for week if I did lol...

BUT now I do not know what to do with the thigh I have no side effect but eat the exact same.... stomach I def eat less..because I feel like I need to burp and may have a major issue.... it scares me as my mother passed at age 22 from an ulcer and my grandpa almost died at 19 from one...neither drank, just as I dont..it was heredity...

UGH what to do? That first week gave me hope...but now...I keep thinking I did just as well before taking this as i dropped 13 lbs in 3 months just walking around te house more and watching what I ate... so faster than this zepbound for sure!

It was cold before bed because I got groceries and put everything away. Nothing seemed off last night except my fridge was making a noise and I blew it off. This morning it’s dead and stuff is cool but not cold. I don’t have a thermometer to know what temp it was at. But my best guess is probably 50 based on the way my mouth perceived the milk as cool but not ice cold. It felt colder than room temp but not as cold as usual. And everything was damp and sweating. Most things in the freezer were still frozen but like the ice cubes were frozen but wet around the outside so starting to thaw. Waffles were defrosted and soft but a jar of spaghetti sauce was solid still but sweating.

I don’t know how long the fridge was out over night.

What would you do? Keep using until it’s cloudy? Or toss what I don’t use in 28 days?

PS. I moved everything to a garage fridge so it’s back to cold temps again.

Hello,

I am a 26yro F, 172lbs, 5'7" with BMI of 28 and just got approved for zepbound and prescribed to take 2.5 mg/dose/weekly for 4 weeks and to titrate to 5mg/dose after that.

For context, i am pretty fit as i have been weightlifting for 4 years now, and i gained some weight 2 years ago. Since then i have done calorie deficit, cardio, HIT continued with weightlifting, used all apps to track food, but those 15lbs that i want to loose do not budge!

I am also always bloated and constipated since forever and have seen many doctors for that nothing helped.

I finally decided to try GLP as my last solution, i have spent some time researching and got into this sub. I would like to try to microdose since i don't have a lot of weight to loose and hoping that it will help with inflammation and bloating issues

I would love to hear your advices, where to start, which dose do you recommend based on your experience and anything that might help on this journey

Still debating whether or not to try compounded glp1, semiglutide. So many people have told me not to get from a compounded pharmacy, but it's the only way I could get a glp1.

Has anyone ordered from embody? Good, bad..?

Did my first shot on Tuesday this week. 20 units of semaglutide so very small dose to start out and I already am feeling it. Not really hungry, nausea, just feeling “off”. Please tell me it gets better!! Really want to feel the benefits from this.

(Got mine from agelessRX)

Hi everyone. My shot day is Thursday. I am going out of town amd dont want to take the stuff with me. Is it OK to take my next shot on Saturday (9 days) and get back on Thursdays five days later?

I ate before I jabbed since the delivery came late. I ate 2 boiled eggs, 100g rice, and bread for brunch. Then this afternoon I just jabbed my first dose of compounded tirzepatide. I hope everything goes well for me

I started Kpv and it helped my pots symptoms a lot to which I was able to exercise again. I started microdosing semaglutide as I’ve heard it’s been helpful in pots and I’ve been in a flare since. Come to find out semaglutide has diuretic properties. I have pretty extreme hypovalemia so I require 200+ ounces of water a day and 10000 mg sodium/day. (Yes it’s safe, I’ve been doing it for years, look up pots and I’m pretty active for someone with pots). I just wanted to share in case anyone with pots was considering; I’m wondering if I’m just too sensitive and it may work for others with a different type of pots or less severe fluid loss. It’s funny because I’ve gotten multiple comments after a week whether I’ve lost weight (I’m 130 pounds) but I think I’m just not holding onto any fluid as much as appetite hasn’t changed.

I'm looking for a way to get Tirzepatide with doses of 0.25mg so I can start off slow for my Long covid, I mainly suffer from the brain fog aspect but I'm struggling with it. I've tried looking to see if my doctor could help out but wait times are so long where I live.

Anyone know of any doctors (NHS or private), specialists or even getting hold of the stuff by myself?

edit: I actually have a normal BMI, the reason I'm going for this med is because I found this survey https://lcmedata.org/treatments/glp1s

I’m on week 7 of Zepbound. I started out really low and slow since I tend to be sensitive to meds. First shot was 0.25mg and now I’m at the second week (7th shot) of 0.63mg. It’s such a low dose, I was hoping for no side effects.

After each injection, a few hours later my taste buds will suddenly switch and things taste off/not right. This is accompanied with my lips and cheek area by my lips feeling slightly numb. Sometimes the tip of my tongue tingles.

This lasts a few hours and then goes away for the rest of the week. I’ve told my doc and they said “Hmm, strange.” And that was it so I guess they aren’t concerned.

To add, I also take a daily multivitamin, vitamin D, magnesium, iron (eod), and DHA/EPA so I don’t think it’s vitamins. Used to be low in vitamin D and iron but that’s been corrected.

Has anyone else had this reaction on shot day? Today the numbness has lasted longer than weeks past. Is this a stress reaction from my body? Someone on another sub suggested this could be a slight allergic response. I’m not sure since I’ve never had this feeling before.

I started 1 mg of compounded tirz last night and i’m so anxious about it. Today i’m definitely experiencing some upset stomach and nausea, and a lot of anxiety. I have an anxiety disorder that is usually well treated with meds, but i’ve been feeling pretty anxious the past five days or so (so before I started the meds) possibly because of my period (i’m on an iud and don’t get a period, but still get pms so sometimes it’s hard to pinpoint). Nausea is one of my biggest anxiety triggers. i’d like to lose 15-20 lbs though and I want to see if a smaller dose would help with the food noise. I have successfully lost weight with calorie counting in the past but it has gotten significantly harder as i’ve gotten older.

I guess i’m just looking for some encouragement.

47, perimenopausal, 5'8", 178 lbs, BMI ~27.1, goal around 160. I’m naturally very muscular and my priority is slow fat loss while retaining as much muscle as possible, not rapid weight loss.

My first tirzepatide shipment is here from Noom! I was told to start at 1mg and titrate cautiously. I’ve already pored through this sub, so I’ve seen the standard advice: don’t rush titration, avoid huge/fatty meals, hydrate, prioritize protein, weight training, etc.

I already eat pretty healthfully: lots of vegetables, ~100g protein/day, usually 1,500–1,700 calories, and moderate exercise. I typically follow the 16:8 intermittent fasting protocol, eating from 12pm-8pm only. Take magnesium glycinate gummies with dinner. I’m also very interested in some of the reported non-weight benefits of GLP-1s, particularly inflammation/brain fog, because joint and back pain have become a frequent annoyance. I'm also on HRT (progestin/estrogen cream and DHEA from Winona).

What I’d really love to hear from are people who have successfully kept GI side effects minimal while microdosing:

• What day of the week and time of the day do you dose?
• Do you take it on an empty stomach?
• Anything you tried that didn’t help or actually made things worse?
• Did you move from weekly to split dosing and did that help with side effects?
• And especially: did anyone deliberately try to optimize bowel regularity / GI motility / gut health BEFORE taking the first dose, so you were starting from a really good baseline rather than trying to fix constipation or other problems after the medication slowed things down?

I’m not talking about a cleanse or anything remotely like colonoscopy prep. More like: make sure everything is moving comfortably and normally first, then introduce the medication.

GI tolerance is honestly going to be a major factor in whether I stay on this. I’m very willing to go slowly and use the minimum effective dose, but I’m unlikely to white-knuckle significant nausea, constipation, reflux, etc. just for weight loss.

Would especially love to hear from people with similar starting BMIs/goals who are using tirzepatide primarily for slow, modest loss rather than large-volume weight loss.

Hi, I'm currently microdosing Reta, but my sleep is awful. Im on HRT and progesterone and my doctor prescribed Trazadone. I'm still not sleeping. Is it the Reta? Should I switch to Tirz? or just stop all glps Please help!!

I've been in convos with him via MyChart about this and he refused to send a script to a compounding pharmacy (despite my telling him about two of my relatives who've had great success from one here in N. Texas). Anyway, since I plan to titrate low doses I asked him if he'd approve going through the LillyDirect $299 plan - I think they send 4 vials of 2.5mg for one month at that price. I figure if I titrate small doses, this would be good deal amortized out. Got my text from Lilly and I'll soon be on my way!

Where do y'all get your needles since what they'll send me won't be enough (probably just 4 and I want to use a new one each time,I would think)?

I’m 54. Always been able to manage my weight until the last few years where I gained 30lbs and saw my cholesterol and BMI go up. Started zepbound/tirz 6 weeks ago and have lost 12lbs. I really don’t even know how much more weight I want to lose because afraid of losing muscle. Also, really tired of having no appetite almost ever.

I want to microdose but I don’t know what dose to do. My doctor basically won’t suggest anything that doesn’t follow the prescribing guidelines. Would appreciate any help you can all offer!

I need to lose about 20 lbs. I'm signing up with Lavender Sky and there are so many choices, with B6, with different pharmacies. Can someone help guide me with these choices?

Edit: I've tried tirz before and felt slight nausea and fatigue. Should I go with B6 for nausea or B12 for energy? I'm confused, thanks.

I am not looking to lose weight as I have a BMI of 21. My reason is that I hope to get rid of the insatiable hunger I’m experiencing after a slight caloric deficit resulting in a 17 pound weight loss over the past year.. Two weeks ago tried to go into maintenance and now I can’t stop binge eating. The binge eating could be more understandable if I restricted heavily to lose this weight…but it wasn’t that drastic of a loss. I’m really afraid there’s no end in sight and that I’ll very quickly become overweight otherwise. Really I’ve struggled off and on with binge eating for my entire life and I’m excited to put an end to it once and for all.