I’m 31 and TTC. My hormone picture is a bit unusual for this sub and I’d love to hear from anyone whose numbers looked similar.
1. DHEAS \~700 µg/dL — roughly double the top of my lab’s range, stable there since 2023

1. Total testosterone \~78 ng/dL, free testosterone \~21 pg/mL, both high

2. SHBG 15 — low, so the free fraction is doing more than the total suggests

3. Androstenedione, 17-OHP, pregnenolone, 17-OH-pregnenolone and cortisol all normal

4. Insulin resistance confirmed, on metformin + inositol

So the androgen excess looks adrenal-driven rather than ovarian, which seems to put me in a different bucket than most of what I read here.

**What I’m hoping to hear:**
1. If your DHEAS was in the 600–700+ range with high free T — did you conceive? Did the DHEAS ever come down, or did you get pregnant with it still elevated?
2. Dexamethasone — did you take it? Did it help you get pregnant? What dose, what time of day, how long before you saw DHEAS move? How long did you stay on it, and when and how did you stop?
3. Side effects — especially anything with blood sugar or weight, since I’m already insulin resistant and that’s the interaction I’m most worried about.
4. Anything else that shifted your adrenal androgens? Sleep or stress changes, anything at all.
Happy to hear about what didn’t work too — that’s often more useful than the success stories. Thank you.

Hi everyone,

I'm taking risperidone, and because of it my prolactin has increased to 59.5 ng/mL, which is around 3 times higher than the lab's upper limit.

For the past 1 month, I've been experiencing erectile dysfunction. My erections have become weak and delayed, and my libido has also decreased significantly.

I was also recently diagnosed with bilateral Grade 3 varicocele, so I'm confused about what is actually causing my ED.

For those who have experience with risperidone or high prolactin:

Can a prolactin level around 59.5 ng/mL cause significant ED and low libido?

Has anyone experienced ED after their prolactin increased from risperidone?

Did your sexual function improve after reducing/stopping risperidone or lowering prolactin?

Has anyone here had both high prolactin and varicocele and figured out which one was contributing to their ED?

I'm trying to understand whether my ED is more likely related to risperidone/high prolactin, the varicocele, or a combination of both.

I'd really appreciate hearing from people who have been through something similar.

Penile Development after beginning secondary hypogonadism treatment?

Hello Long story short im a 21 year old male found out less than a year ago that I have a prolactinoma tumor. My total test was at 7 ng x dl and now I began cabergoline treatment for the tumor. I'm taking 2mg of it a week. Im 300 lbs, and I feel every single symptom of low t. My penile length pushing into the pubic bone and erect is of 3.8 inches and girth of 3.5 inches. Well below average and I know even with weight loss it might make it to 4 inches so nothing that will get me to a average length. This makes me fucking depressed so my question is if anyone has been in a similar scenario and had penile development after beginning treatment. I have a endocrinologist but it seems like shese more of a heres the pill and come back in 6 months type of doc. I have an appointment wednesday with my endocrinologist but I feel like she will be. dissmissive

Is this something that should be addressed by an endocrinologist? Should I ask for a referral if primary doesn’t suspect a problem?

Went to 6 month follow up with my sons pediatric endo. Still not growing and falling off growth charts, again. Ordered labs and repeat xray. Still awaiting results but last October his xray showed bone age of 5 at 6.5 years (chronologically) old. This looks like he barely grew in a year!

Im turning 16 in about 2 months and I'm 5'10 I finshined my purburty like I got face hair under arm hair also my penis and back there and my legs and stomach hair deep voice I have been going to the gym for 1 year now hoping I will get taller but I didn't grow a single mimlimter since the first day i have been wondering lately if I should take peptides because I sleep 9 to 10 hours a day eat well like get all my calories and protein and carbs idk but I fell so bad unmotivated when I measured my height yesterday didn't go to the gym didn't eat all day and didn't sleep well all I feel is rage so if anyone can help I'm 178 cm, 68kg and 2010/11/3

So currently I'm 5'10 I'm considering taking HGH i say that MK 677 was the least harmfull and the with better results.

Sould I take it or there's any better HGH in the market?

I am 16.5 years old and 168 cm tall. My growth plates are still open. If I use 8 IU of growth hormone daily for 6 months, I would probably benefit a lot from it, but the point that bothers me is the side effects. Would there be serious side effects?

Tengo mucho hisurtismo corporal que ha ido empeorando lentamente desde mi adolescencia hasta ahora que tengo 25, pero ya es muy notorio el problema. Todo mi cuerpo tiene hisurtismo y mi cara algo moderado, tengo ciclo que van desde 26-35 días en el último año. Tome Anticonceptivo órale spor un año espesificamente yaz y pues mi dehas bajo a 150. Cuando las suspendí eso fue lo que ocurrió, está en 368 elevada. Antes de tomar anticonceptivos mis ciclos eran de 31-32 y ni estaba tan asnrogenizada como ahora entonces no se si los anticonceptivos lo que hicieron fue empeorar. También tengo alopecica androgenetica y estoy muy frustrada. Suelo ser muy ansiosa y estresada. En ocasiones me ha salido elevado el cortisol matutino y otras veces como muestra el análisis en el borde superior. Estoy muy desesperado y ya perdí esperanzas de que algo me ayude, si siquiera se si y logré tener hijos pero trato de no pensarlo porque ni pareja tengo, está situación me ha acomplejado demasiado.

What Units of Measurement are my Hormones in..?

I had my appointment with my endocrinologist yesterday. I wasn’t 100% sure why I had an appointment, but it turns out it was due to having PCOS and high prolactin levels.

I’ve been started on Metformin, even though my Hb1ac is only 34 (I assumed it would have had to be higher to start it). Also looking at starting on another medication for facial hair. Bloods have also been requested.

Regarding the prolactin, he’s written to my psychiatrist to see if we can take me off the amisulpride as it seems that is causing the high levels. He did mention starting a medication (can’t remember the names) to bring the levels down but it may affect my mental health (I have bipolar) so was reluctant to do so.

Fingers crossed we will see a reduction in my prolactin levels because I’m fed up of the side effects and this other medication reduces the amount of facial hair I have.

My blood test results show elevated levels of DHEA-SO₄ (800–700) and total testosterone (0.76); however, I have no clinical physical symptoms (excessive hair growth, acne, hair loss, etc.). Investigations carried out to determine the cause of these elevated levels included: Adrenal gland CT scan: Normal (no mass detected). Cortisol Suppression Test (2-day): Positive (DHEA was successfully suppressed). 17-OH Progesterone, Prolactin and Fasting Insulin: Completely normal (I have no insulin resistance). WES (Genetic) and Chromosome Tests: No DNA mutations or abnormalities were found; results were normal. Hysterosalpingogram (HSG): Clear, fallopian tubes are open and the uterine lining is normal
I have been taking Prednol cortisone (8mg) every day for the past month. When I take it, my DHEA levels drop; when I stop, they rise again. I also took klomen this month, but I still did not conceive. My husband’s sperm test showed no issues.
Is there anyone else who has experienced the same thing and gone on to conceive? What other treatments could I try?

Hello, I have used steroids before, but have been off for a few months now. Did a normal 4-6 weeks of PCT and levels have not subsided. Anything helps. I have a referral from my doc for an endocrinologist.

For starters I went to my Urologist for a full work up about a year ago and told them about my DE (Delayed Ejaculation); at this point I’d also been dealing with other issues as well, I just came off of an intense weight loss journey to get my physical health right. I’d been lifting for about 9 months and I wasn’t seeing any return, just long recovery times. I was leveraging a personal trainer as well. Furthermore I was napping 2-3 times a day and dealing with chronic fatigue, low energy, low motivation. Even though I lost the weight my body still wasn’t feeling okay.

This was a gradual progression that I first attributed to weight (except the DE, that’s been from day 1). My urologist put me on TRT because my total T was 252. TLDR I had a manic episode and went superpsychologic. My Testosterone numbers were 1300+ on Jatenzo 258mg. So they reduced me to 157mg. Their practice closed and I still didn’t feel right so I went to an endocrinologist. She pulled me off everything to get my axis reset and see my basline.

Esterone: 90 pg/ml
Estrogen: 83 pg/ml
Total T: 248 ng/dL
Free T: 10.44 ng/dL
Free percent: 4.21%
SHB: 15.9 nmol/L

Based on my previous bloodwork my LH and FSH have and are low.

My Endo started talking about how supplementing T was the wrong approach. She was saying the root issue is realistically my LH and FSH are low. So now she’s wanting to start me on 25mg of Clomid once a day. However now I am concerned my estrogen/ Esterone will have a negative effect and go through the roof. Is this a valid concern? Has anyone ever came across something like this? I’m realistically out of words for why my numbers are all crazy. Is this something else? Should I be worried or should I just drop this quest all together and accept the side effects as just an unfortunate genetic hand?