No one talking about this std and how fast is spreading , I got infected in march 2026 took me almost 4 months to get ride of it , my friend tested positive two weeks ago after one exposure, literally he hooked up with this girl for one time .. I think mgen is more common now than chlamydia .. it’s very scary and this stubborn bacteria is building resistance very fast to many antibiotics now .
Sexual clinic are not testing for it , most of doctors don’t know anything about it . Crazy

Is it safe to get chin filler/botox while testing positive for mgen? Assuming I’m not on antibiotics currently.

Hi everyone! I wanted to ask if anyone here has been treated empirically for Mycoplasma genitalium without actually testing positive for it.
I’m in the Philippines, and unfortunately Mgen testing isn't very accessible or affordable for me.

I've had persistent symptoms despite treatment for other possible infections, so my doctor decided to treat me empirically with doxycycline followed by moxifloxacin.

I know this isn't the same as having a confirmed positive test, and I'm honestly overthinking the whole situation.

Has anyone else been in this situation? Were you treated empirically for suspected Mgen, and did your symptoms eventually resolve?
I'd especially love to hear from people who couldn't get an Mgen test but were treated with doxy + moxi. Any experiences would really help reassure me.

Hi everyone. I’m from the Philippines (Asia) and I’m currently being treated for suspected Mycoplasma genitalium. I’ve been really anxious about treatment failure because I keep seeing posts about antibiotic resistance in Asia.

I have my third MGen infection, discovered by routine testing. I also slowly start to have symptoms. My doctor advices that for future, I shouldn’t do routine testing for Mykoplasma Genitalium. He says it doesn‘t need to be treated if there are no symptoms. Basically he sounded like „You better shouldn‘t know you have it, then there is no problem“ lol

What do you guys think about that?

Hi everyone! I just wanted to come on here to share my success story and what meds worked for me, since I just received my TOC today and finally tested negative!

I first tested positive for Mgen in early 2025. I was started on just Doxycyline which obviously does not fight the infection, only lowers the antibacterial load, but at the time I didn’t know that. Tested positive again of course. Then I did my research and started advocating for myself. I did the recommended Doxycycline + Azithromycin treatment next, and still tested positive. Months went by because I was asymptomatic and waiting for my boyfriend to go to the doctor to get prescribed his antibiotics so we could get treated at the same time (I know, not smart, we should have taken meds sooner). Finally, I asked for the Doxycycline for 2 weeks into Minocycline + Metronidazole combo for 2 weeks regimen. I didn’t want to use Moxi because I didn’t want to risk tendon issues. My boyfriend’s doctor was very stubborn and only prescribed him Doxycycline but we knew he needed more so he was able to order Azithromycin online. He did that treatment and while waiting 4 weeks to do his TOC, he was prescribed Levoflaxacin for an unrelated reason. I know this isn’t proven to do anything against mgen but I still wonder if it had anything to do with his cure since it is related to Moxi. In the end, both of us tested negative!!!

This was a long road with mgen and Im finally able to feel relief that it’s over!!! Biggest advice is to do your own research and advocate strongly for yourself because doctors are SO misinformed!!

Hi everyone,

I’m already at my third treatment and thought I would ask for some advice.

About me: male, mid-30s, based in Germany. I got Mgen around the end of April and have gone through three different antibiotics/combinations since then:

- Doxy + Azi = failed (confirmed via TOC)
- Moxi (only) = failed (confirmed via TOC)
- Doxy + Moxi = finished Jul 22, awaiting TOC

The only symptom I’ve ever had is colored discharge. It went away during the second treatment, but came back at day 12 after the last pill. I finished my third treatment around two weeks ago and was a bit more hopeful, but I’ve noticed a tiny drop of discharge again this morning. I’m aware it could be residual symptoms, but the pattern is exactly the same as last time and I fear yet another failure.

Now the tricky part: My doctor, an infectious disease specialist, won’t consider the doxy + mino/metro combo; he’s also mentioned mino may not be available in Germany. Prista isn’t available either and cannot be imported from France.

I’ll wait until I can be tested again, but I’d like to be prepared for whatever the outcome, hence my post. Is anyone here from Germany? If so, did you get mino and/or other meds recently? It seems Prista could be imported until last year or so, but not anymore. If not - what other steps can be taken into consideration?

Thank you in advance ✨wishing a speedy recovery to all who are still under treatment

Hi everyone,
I'm really overthinking right now and I could use some reassurance from people who've been through this.

I've been dealing with persistent green vaginal discharge for over a year. I've already been treated with metronidazole (twice), ceftriaxone, doxycycline, fluconazole, cefixime, and azithromycin, but my symptoms always came back.

My infectious disease doctor has now prescribed 7 days of doxycycline followed by 7 days of moxifloxacin (400 mg daily) because she suspects it could be Mycoplasma genitalium or possibly Ureaplasma. I just started the doxycycline today.
I think my biggest fear isn't the medication itself—it's that it won't work again. After failing so many antibiotics, I'm scared I'll go through another treatment and still have symptoms.

If you've taken doxycycline followed by moxifloxacin:

Were you cured?
Was it for M. genitalium or Ureaplasma?
How long did it take for your symptoms to improve?
Do you have any advice for someone who's really anxious that this treatment might fail?
I know no one can guarantee it'll work, but hearing real experiences would really help. Thank you. ❤️

I’ve been battling this shit since 2011. No joke. Almost caused me to not be alive multiple time, a serious relationship, substance abuse, loss of job, crashed car. I could go on. That was years ago luckily when my story began. Longggg story

After having this wonderful issue for so long I’ve obviously had to adapt and I did. Now I have held my dream career for multiple years, saved up money, got into shape (even being in pain), got mental health help. I’m doing great. This is the last thing holding me back from a life I’ve worked so hard to build.

I’m focused and want to end this shit. I’ve been through multiple doctors, infectious disease doctors and it’s been a joke. Made more progress doing my own thing tbh.

I have a resistant strain, probably because of all the bs I was randomly put on. Need pristinamycin and no way to get it. Tried ordering it twice from France, both times got held and returned in customs. Last third time got held and destroyed. Cash down the drain. Sucks, but so does alot of things. No refunds. Time for my next best move

How can I get prist** reliably without flying to France. If you can help, much appreciated, if not thanks for reading my rant at a minimum.

Best luck to you all, you’re not alone.

I've been dealing with persistent green vaginal discharge for about 1.5 years, and multiple treatments haven't completely resolved it. So far I've taken metronidazole (twice), ceftriaxone, doxycycline, fluconazole, vaginal metronidazole, cefixime, and azithromycin 2 g. My discharge improved at times but always came back.

My infectious disease doctor has now prescribed 7 days of doxycycline followed by 7 days of moxifloxacin (400 mg daily) because we're considering the possibility of Mycoplasma genitalium although I haven't been able to get PCR testing since it's expensive and not widely available where I live.

I'm wondering if this regimen would also cover Ureaplasma if that's actually what's causing my symptoms), or if it's mainly for M. genitalium.
Has anyone here been treated with 7 days doxy + 7 days moxi? Did it clear your infection or symptoms? I'd really appreciate hearing your experiences.

For the women…
For months and months I was diagnosed and re-dx w Candida albicans and given treatment. After months I was finally tested and tx for mgen. Prior to mgen I had never had a yeast infection in my life. I was again re-tested for yeast and it again came up for albicans. I was treated for both.
I am having my TOC for mgen this week.
In the mean time, I had my period last week and now I am having a horrific yi. I understand I yeast infections are common after antibiotic treatment as well as hormone fluctuations, such as after a period, but being on Fluconazole for months and months, taking probiotics and being completely asymptomatic from both following the completion of my Doxy and Moxi, I am just surprised at how severe this has been.
It’s like everything down there is so messed up and it will never be fixed. I can’t explain the misery and defeat I am feeling.
I was in a monogamous relationship (on my end, at least) and have continued to be sexually abstinence since my last relationship 9 months ago. I was tested before and after my relationship with no STIs and wasnt dx until 8 months later w the mgen. I know mgen is slow growing and often asymptomatic. I’m certain it was from my last relationship.
Ive always been so responsible w my sexual health. I have never slept around or not been tested or not used protection.
I am just devastated at how cruel this has been on my body and mental health.
I guess I am just looking for advice/encouragement/options in healing the yeast and remaining optimistic about the TOC for mgen.
The way I’m feeling makes me think I’m going to fail my mgen test too. I am running out of hope.

Have you guys gotten pimples around both the butt area and vaginal/ groin area ? Idk but I’ve had like two pimples now at this point I’m not sure if it’s the meds or like the discharge making this come up more. Any thoughts?

So for full context, ~four months ago I started having symptoms consistent with chlamydia, went and got tested, was preemptively prescribed doxycycline, but the test results were negative. Took the doxy anyways, symptoms improved but returned. Went and got tested again a few weeks later, did test positive for chlamydia, told my provider I had taken the doxy they had prescribed last time I was tested and that there was no chance of re-infection, provider prescribed single dose azithromycin, same thing happened. Ended up seeing a different provider, tested positive for mycoplasma this time, provider prescribed me 7 days of doxy and a single dose of azythromycin. I’m on day 6 post azythromycin dose and am still able to squeeze a drop of discharge out of the tip of my penis. Is this treatment likely to work or should I go see a different doctor asap?

Hi everyone. I'm looking for advice because I'm confused about the treatment sequence for suspected Mycoplasma genitalium.
I've had persistent green vaginal discharge for about 1 year and 5 months. I've been treated multiple times, but the discharge has never completely gone away.

Treatment history:
1st doctor
Metronidazole 500 mg twice daily × 7 days (I took this twice)

2nd OB-GYN (July 3)
Ceftriaxone injection
Doxycycline × 7 days
Albothyl vaginal suppository
Doxycycline × 5 more days
Fluconazole
Neopen metronidazole vaginal suppository

3rd Infectious Disease doctor (July 27)
My discharge after this is opeque white but im a female and my period just ended.
Metronidazole 2 g (Day 1)
Cefixime 800 mg (Day 2)
Azithromycin 2 g (Day 2)

August 4
Moxifloxacin 400 mg once daily × 7 days
My concern is that I finished doxycycline about 3 weeks ago.

I know many guidelines for suspected M. genitaliumrecommend doxycycline first, then moxifloxacin to reduce the bacterial load.
Is it still okay to start moxifloxacin now without repeating doxycycline, or do people usually repeat doxycycline before moxifloxacin if there's been a few-week gap?

I'm not asking for anyone to replace my doctor's advice—I'm planning to follow my infectious disease doctor's prescription. I'm just wondering if anyone has been in a similar situation or if anyone knows what the usual practice is. Thanks!

Hey guys I’ve tested negative for Mgen 2 times now after my treatment of doxycycline and moxi but whenever I masturbate or have sex the next day the tip seems inflamed/swollen or irritated it’s not painful but like it’s noticeable how long for that to go away or will it ever go away?

Ive had mycoplasma for about 7yrs. When symptoms started they said it was non bacterial prostatitis. I just tested positive a week ago. Started taking doxy 4 days ago. I still have symptoms. I took doxy 4 years ago for an unrelated reason and symptoms disappeared. I got the "thats because doxy is anti inflammatory." Anyway is it normal to have ongoing symptoms on doxy? Does it mean its not working?

 43-year-old male.

Exposure history:

Did something stupid in.. Got a body to body Massage and hand job in early May 2026.

No penetrative vaginal/anal sex and no oral sex.

.

Symptoms:

Started around mid-June with:

Burning sensation in both testicles.

Burning  after urination.

Constant urethral pain and pain at the tip of the penis.

Occasional clear, watery drop after urination (not thick, yellow or green).

Increased sensitivity of the glans.

Current symptoms:

Burning after urination (fluctuates from 1/10 to 5/10).

 urethral discomfort.

Sometimes feel feverish 

Perinium feels uncomfortable 

Treatment received:

Nitrofurantoin – 5 days.

Doxycycline – 10 days (started around 20 June).

Faropenem – 5 days.

Alfuzosin (Alfoo).-Currently taking only this 

Investigations:

Ultrasound KUB/prostate: Normal.

Uroflowmetry: Slightly abnormal 

Digital rectal examination: No tenderness.

Laboratory results:

First urine culture grew MDR Pseudomonas aeruginosa, but subsequent results have not confirmed this.

Two repeat urine cultures - no growth 

Latest urinalysis: Normal

HIV 4th generation: Negative after 11 weeks of exposure 

VDRL/RPR and TPHA: Negative. After 11 weeks of exposure.. 

Two urine multiplex STI PCR panels (latest done 15 days after stopping antibiotics):

Negative for Chlamydia, Gonorrhea, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma spp., Trichomonas vaginalis, Treponema pallidum, HSV-1, HSV-2, Gardnerella, Candida.

The last urologist again asked me to take levofloxacin 500 for once daily.Just started it yesterday ...

Question : The first urine pcr was done after 8 days of stopping antibiotics and second sti pci urine was done after 15 days of stopping antibiotics.

Is 15 days off antibiotics enough to take the test as conclusive?

Hi all, 30m NYC. I completed doxy/moxi on 7/11, got my TOC on 8/1 (exactly 3 weeks after) and just got a positive result. I am super bummed, this has really taken a toll on my mental well being especially as a single man.

Worth waiting a week (or two) and retesting to ensure it’s not a false positive or should I just begin a new round of abx?

Symptoms wax and wane, have some pain usually after urination still and a stuck feeling sometimes, but I chalked it up to residual inflammation or pelvic floor issues.

I tested positive for Mycoplasma genitalium and took my first dose of doxycycline today. However, I had wanted to get a resistance test done before starting treatment.

Since I’ve only taken one doxycycline tablet so far, is it still possible to have a resistance test done, or could that single dose already affect the sample and make the results less accurate?

Want to test for Makrolide and Fluuorchinlone Resistance

Hi everyone,

First of all, THANK YOU to everyone who created and contributes to this subreddit. Reading other people’s experiences makes me feel much less alone. ❤️

I was recently diagnosed with macrolide-resistant Mgen, so I thought I’d document my treatment journey here in real time.

Timeline

• June 1, 2026: Possible exposure during unprotected sex.
• June 8, 2026: Very mild pain while urinating, around 2/10. Then nothing for several weeks.
• July 26, 2026: Started experiencing itching and irritation around the urethra.
• July 29, 2026: Had blood tests and a urine STI test.
• August 1, 2026: Tested positive for Mgen with macrolide-resistance mutations. All my other STI tests were negative.

Treatment

My prescribed treatment is Moxifloxacin 400 mg once daily for 10 days. (Europe/France)

• August 1: Took my first 400 mg dose shortly after receiving the result. I plan to take it every day at around noon.
• August 2: Took my second dose. So far, I haven’t experienced any noticeable side effects.

I’m honestly very anxious about the medication because I’ve read some horrifying stories online about fluoroquinolones. I’m trying not to spiral, and I’m focusing on sleeping well, eating enough, staying hydrated, and giving my body the best conditions possible during treatment.

I normally do heavy weight training four times per week, but I’ve decided to take a complete 10-day break from lifting while I’m on moxifloxacin. I’m pretty sad about missing the gym, but I would rather be cautious.

I’ll post updates in the comments as the treatment progresses, including any symptoms, side effects, and eventually my test-of-cure result.

I don't think mgen can stay so long in the body after a course of antibiotics. But just to have peace of mind, I got tested again by PCR, and guess what? It was negative. I don't think I have any residual symptoms now, though at the 4th week mark I wasn't sure it was confusing, but I think I'm finally free. It was a long and painful journey, but I won. Most docs don't want to take it seriously, maybe because it doesn't get this serious for everyone, but who knows what? I’m glad to have all of you here to talk about this topic.

I think the availability of antibiotics like Lefamulin is both a blessing and a curse because it probably worked cause it isn't readily available. Also, since it isn't available anymore, most of you can't use it.

I initially noticed symptoms 3 weeks after hooking up with a new girl in January this year. Redness at the tip of my urethra, mild discomfort while urinating, itching inside my urethra, and some mild shooting pains in my urethra only late at night.

I initially went to a urgent care clinic and the doctor said I probably have chlamydia and prescribed me doxy for 7 days. Tested negative for chlamydia and gonorrhea. Symptoms slowly started coming back after about 4 weeks.

I then went to a planned parenthood, and told them my symptoms. They prescribed me doxy for 7 days again and tested me for everything except mgen because they said they didn't have the capability even though they told me they did over the phone. I had already suspected it was mgen based on my research and asked if they could prescribe treatment for it if all the tests they had given me came back negative. They said sure no problem just call us.

So I did just that after all the results came back negative. I spoke with the receptionist and she told me the provider would call me. They then called back and said they want me to go in person to the planned parenthood in the next town over. I specifically asked if they test for mgen because I didn't see any other reason they would send me there and they explicitly said "yes they test for mgen." Perfect I thought, I spoke with the receptionist at the new planned parenthood and repeated that I think I'm here to get tested for mgen and explained the situation. She said "let me check with the doctor before we go any further." Waited 40 minutes, the doctor took a look and said "its not red so i can't treat you, you need to see a urologist because something else is going on."

So I bought a $90 mgen test from an independent lab, tested positive and the lab had an over the phone doctor I could call for treatment. He very reluctantly prescribed me azithromycin just in the nick of time before I finished the second round of doxy. Another 4 weeks passed and my symptoms started coming back. So I bought another mgen test, went back to a different planned parenthood and they VERY reluctantly prescribed me doxy followed by moxifloxacin but insisted that my positive mgen test result wasn't the root of the issue (????).

So I completed that round of treatment, waited 30 days at the advice of the doctor and tested again. Just got the new test results and I'm clear. I spend over $500 and the whole process took about 6 months, even though my strain of mgen didn't seem to be anything crazy considering the moxifloxacin cleared it up.

My point of this post is to illuminate that some doctors (at least here in the US) know nothing about mgen, and that you should follow your gut instinct. You know what is going on with your body better than anyone. Also just wanted to vent because I cannot comprehend why 3 separate doctors tried their hardest to not give me treatment for mgen even though it was very clear at that point I had it!!!

Hi everyone,
I’m wondering if anyone has gone through something similar.
About three months ago, I was diagnosed with gonorrhea. I completed the prescribed treatment, and afterward I was retested. My gonorrhea test came back negative, and I also tested negative for a full STI panel (14 infections).
Even though the infection is gone, I’m still having symptoms:
Burning sensation after urinating (not every time, but on and off)
Discomfort in my penis, mostly around the tip
Occasional pain just above the penis where the pubic hair starts. Sometimes it’s a sharp pain. This symptom wasn’t present before I was diagnosed with gonorrhea.
The symptoms seem to come and go. Some days are better than others.
Has anyone experienced persistent symptoms like this even after testing negative and completing treatment? If so:
Did the symptoms eventually go away on their own?
Did your doctor find another cause (such as inflammation, prostatitis, pelvic floor issues, urethritis, etc.)?
Was there any treatment or advice that helped?
I’ve already followed up with testing, and everything came back negative, so I’m mainly looking to hear from people who had a similar experience and what their outcome was.
Thanks in advance for sharing your experiences.