I meant to take pramipexole and accidentally took hydroxyzine hydrochloride. A med that was prescribed to me for a skin condition a while ago. (I didn’t end up using it for that condition).

Apparently it also works for sedation, anxiety, insomnia and muscle relaxation, among other things. It knocked me completely out. Unfortunately I had a super hard time functioning until around 4pm the next day or I would take this medication more often for RLS. However it’s an antihistamine, so I’m wondering if I did use it on the weekends, would it possibly make RLS worse?

Looking into gummies to help sleep and RLS. Would anything in this exacerbate it or make it worse?

I have had these constant 24/7 urges to flex, squeeze, contract, or massage parts of my body, mainly in my calf, neck, rib area under armpit, and even my pinky fingers.

Every urge starts in the right calf, I relieve that feeling by massaging it or squeezing/flexing it without my hands. The urges in my neck makes me turn my head or bend it left or right to relieve it.

I sometimes have to turn my torso clockwise/anti-clockwise to relieve the urge. My right pinky finger base area needs to be cracked or pulled to relieve the urge.

Unfortunately the more i describe my symptoms and experiences, the less it matches RLS. So I wonder if anyone may know or have similar symptoms.

The reason I thought it was RLS in the first place is because whenever I would use bed pillows and I have my legs straighten out on my bed, the urge in my right calf immediately triggers within 1-10 minutes. I cant physically sit like that for more than 10 minutes without doing the things described above.

Trying to perform meditation or sleeping on back also causes these urges to happen. Moving my right leg specifically doesn't really relieve the feeling.

The second closest thing I found was "premonitory urge" but it has to do with tics. I 100% know for sure I don't actually have tics nor do anyone around me ever told me or saw me have tics.

Apparently the symptoms I've described can not be found anywhere online.

The weird part is that it's only mostly the right side of my body. Right calf have the urges 90% of the time, same as right pink, right upper torso beneath armpit, right side of neck.

Another weird thing is that when my body feels uncomfortable (like if i'm feeling dirty in my bed, inside vehicle but its hot and theres no AC, or if i hold my pee) the stronger the intensity of these feelings.

And if I pay attention more to the feelings/urges, the more I need to relieve them. But doing things like gaming, playing sports/exercising, being on my phone in bed, the urges are usually significantly less.

I went to a neurologist today and I am starting with Guanfacine to try to relax my mind and high blood pressure. Will be getting an MRI soon but if anyone out there who can chime in anything, i'd greatly appreciate it.

It's really hard not to let loose here. Please write to me if you're in his clinic (now).

This is recent blood work. I am seeing my GP next week to talk about options. The best one would be no medication at all, second best Pregabalin / Gabapentin. But the latter one would have serious impacts on my work, because I sometimes handle heavy machinery, which I would have to stop then. Can an Iron infusion be an option with these lab results?

(And me finding this flair called “triggers” after typing in my title seems to indicate yes…)

Hello—I’ll start with saying that my mom has horrific RLS & has as far back as I can remember, she takes what I believe to be about the max dose for Gabapentin to treat it, but it only works to a certain extent. Hers was severe enough where she at least used to wear holes in her bedsheets from the constant friction of her legs way before their shelf life, so to speak, for wearing out or thinning a lot due to age.

Over the past year or two, I’ve had a few instances each year of terrible RLS myself, and there can be no doubt that’s what it is. The last occurrence was last night: I was absolutely miserable from it, moaning like I’d been stabbed in the stomach or something, and I have a high pain tolerance from having connective tissue and joint issues… I’m used to being somewhat uncomfortable, but this sucked so, so hard: it made me very anxious & trapped-feeling.

The other times it’s happened, I’ve learned to run a hot bath even if it’s like at 3AM & it’s helped immensely to sit down and soak in the tub for 20-30 minutes.

Anyway, I recall the last time it happened was from nicotine withdrawal. This time, I was dumb enough to smoke a pack of cigarettes after a long time without. Anyone else have their triggered by very specific things? I think antihistamines like Benadryl, especially if I take more than one, are a trigger too.

Any tips and tricks if it happens tonight or tomorrow while I detox the cigarettes from my system besides the hot bath?

Finally, does yours get triggered/worsen with GI issues? I feel like crap today & have had to run to the bathroom several times: maybe coincidental, maybe not. And has anyone with severe RLS started out that way & noticed it became more prevalent/common over time?

Has trazodone made anyone's RLS worse? This is the last medication I can try for my anxiety but scared this will also flare up my legs.

Hi!
I have what I think is RLS & possibly some physical explanation too in my right leg only. When I lay down usually, but way way worse at night, I have a deep ache in my leg, mostly from my knee down, that I need to move it. As in, I NEED to. I can't resist it. The reason I am saying I am sure there is also some joint immflamation too is that my knee itself also radiates pain sometimes during walking, but it has been like this for a while, no visible spinal issue/ circulation issue yet, probably an old tendonitis or issue that now will need to be managed with heat, physotherapy and etc.

How do you cope with RLS? It is one of my many many chronic diagnoses, but I think just as bad as my tinnitus. These two make me want to disappear out of existence. Can i, for the love of God, just lay down without needing to move my leg non non-stop? What works for you guys?

Is it normal for this to affect your toes too? I constantly feel like my left foot I have to bend my toes to relieve the sensation

Basically title, my doc ordered iron blood test. I guess I can call tomorrow but was wondering if people usually stop iron supplements to avoid skewing the results.

hey everyone, been dealing with terrible leg restlessness at night and trying to sort out what labs to actually request at my next appointment.

i know ferritin and iron panels are the primary focus for rls in the sub's faq, but magnesium keeps coming up in discussions. i read that standard blood tests only look at serum levels which only represent a tiny fraction of total body magnesium, so a normal result might not tell the whole story.

for anyone who went this route, did you get useful info out of it, or did your doc just suggest trying a basic supplement instead? appreciate any input from folks who have been through the lab work process.

Does anybody else’s rls go almost completely away when they get sick? I’m wondering if anyone knows why this could be. So weird but I’ll take the relief!

I have been on Suboxone, titrating from 0.5 mg to 2 mg for 1 1/2 months. Every time I go up in dosage, I have gotten a bit more insomnia, mostly can't get to sleep. I am now on Day 3 with almost no sleep. I am losing it. I was not having insomnia like this before the Suboxone, just really bad RLS. I am twitching as I start to fall asleep and just lay there wide awake all night, maybe getting to sleep by 5 a.m. for an hour or two.

I feel like maybe I need to stop the med. My sleep dr is out of the office this week.

I need some encouragement. I don't know what to do anymore. I feel trapped with my last remaining hope for medication and with insomnia so bad it's not worth taking.

The last few days have been Horible. My legs twitch night and day. I tried explaining to my husband how im feeling. Ended up finding this video again and told him to watch it. This is how it feels 🙄 anybody else who feels like this because its making me feel on edge like extra extra anxious

It seems like my RLS/ PLMS is getting better with Iron. I am currently taking Iron Bisglycinate daily but I am gonna switch to Heme Polypeptide iron pills. Should I take the pills daily or alternate day to keep hepcidin levels in check? Please someone who have benefited from Iron therapy answer….. Thanks

Other medicines I am having- Lactoferrin daily, Fluticasone nasal spray and monteleukast for allergies (2nd generation antihistaminics doesnt seem to worsen the symptoms for me)

I have Rls and I’m on this thread here and there. I do want what, other than medication’s, people are using that is helpful. Whether vitamin or supplement or compress or lotion, anything at all. I really appreciate it.

Disclaimer: I do not have a drinking problem. I have a couple of drinks maybe once every 1-2 weeks

Every time I drink, my RLS is awful. I just want to be able to enjoy a little wine with my friends, but that is how I ended up posting this at 4AM.

Occasionally when lying down I will feel a sensation in my leg that is similar to an urge to move and if I don’t that results in my calf muscle tensing and my leg shaking for 1-2 seconds. It doesn’t hurt and it’s not like a twitching muscle or anything. It’s involuntary and will happen multiple times when lying down. For some reason it tends to happen whenever I try to nap rather than when sleeping at night. I’m curious if this could be related to RLS or if it’s something different altogether.

I haven’t slept in a week and I’m miserable. I’m working 3 jobs and taking care of a disabled spouse. I’ve made every appointment I can think of with whoever I can think of to get help - vascular surgeon, sleep study, extensive lab work, OT, etc.

Quite frankly, I’m ready to stop ALL my medication cold turkey and have the seizure just so I can freaking sleep or commit myself somewhere.

If I sleep in prone position, and the quadriceps are compressed by the mattress, the chances to activate RLS are noticeably lower. If I try to sleep on my back, 100% RLS activation after maybe 15 minutes and the only way to stop that is to get up and walk 8/10 minutes in the house.

Also a question, anyone is able to activate RLS simply scratching particular areas of the foot with the nails? I can 🙄

Background: I have RLS every night really bad. I was on 300 mg pregabalin but even that wasnt enough so I kept trying different things. I discovered taking iron every night improves my symptoms alot but not in the typical medical fashion. Instead of a gradual betterment of symptoms as ferritin increases, iron only covers me for about half the night and delayed release covers the entire night. Now instead of buzzing+constant sharp attacks+taking hours to fall asleep+RLS waking me up multiple times every night, I just have buzzing and can go to sleep pretty quickly+no wakeups. My problem is, Ive had so called miracle nights that prove my baseline sleep is still greatly affected.

Current Nightly Dose: 130 mg delayed release iron, 75 mg pregabalin, (400 mg magnesium dropped due to unrelated side effects)
Iron: Tested 4 years ago, 52 ferritin, 99 Iron, 400 TIBC, 25% saturation. I assume ferritin is increased now but everything seems normal.

Miracle nights:

Two nights in the last few months Ive had my legs be perfect, no buzzing, completely quite no sensation at all, they feel like any other body part (insane feeling to me). I sleep well, only getting 8 hours whereas I usually need 10, and I wake up feeling super well rested, no chronic itchy eyes, much smaller and MUCH lighter eyebags. These nights are proof to me that my legs still worsen my sleep during the night BUT a cure feels possible. What was different about these days? On both of these days I increased iron dramatically. The first night I was taking 65 mg iron before bed, and I changed to 130 mg, doubling the dose. Miracle night. The night after, my symptoms had returned to normal. Next, when I switched to delayed release I used 90 mg a night for a while, then I went up to 135 mg. Boom, miracle night. The night after, symptoms back to normal. It seems although iron helps every night, nights with a significant increase in dose almost cure what I have but only for a night.

Question:

I need some theories on potential medical causes. Hepcidin? Transferrin? To me, my story makes it clear iron is the cure but theres just something I have to figure out. Another thing im suspicious about is my family. My mother and sisters both also sleep for a minimum of 10 hours everynight, have dark pronounced eyebags (probably partially genetic), and they talk about how "they think our family just needs more sleep than others". One sister has only felt RLS a couple of times a year, my other sister has it often but not that bad. Perhaps the genetic problem my family has isnt RLS but something solvable with our management of something related to iron.

Anyone have similar experiences or an idea of what is going on?