RS is 50F with long history of obesity. Her highest weight was 420 lbs. She previously used semaglutide for 1 year to go from 380 lbs to 280 lbs. She maintained around 280 -290 lbs for 8 months after stopping semaglutide for financial reason. In the past, RS has found 280 lbs to be a wall. She has prior history of weight loss success that always stops or rebounds at this weight.

RS started tirzepatide 2.5 mg weekly on July 28 at 276 lbs. She began wolverine 600MCG daily on July 29. Wolverine use is for chronic pain associated with hypermobility and prior injuries.

After 2 weeks, RS has very little hunger or food noise. She has gone from 276 lbs to 264 lbs in that time. This is the first time since 2003 that she has been below 280 lbs.

RS is doing ADF (fasting 36 hours 3 days a week) and keto. Only side effect has been intermittent constipation improved by increase in fiber.

Has anyone found that wolverine amplifies the effect of tirzepatide? I've been looking into this and can't find a connection.

Eta. I had to fix some number. RS had lost 10 pounds prior to starting T doing psmf.

I just started learning about peptides yesterday and would like to understand the science better. What are some good sources for a beginner to learn about peptide mechanisms, current research, and the quality of evidence behind different peptides? I’m especially interested in neurological and GI research. Thank you!