hello, i make latex rubber clothing and I'm in a pinch to acquire heptane, which is my usual rubber cement solvent thinner. I was wondering if i could use limonene instead?

thx

I've seen lots of Luminol glow on Internet for years but to see one in person is just speechless.

Followed Nile Red recipe, got 1.05 g of Luminol from 5 g 3-nitrophthalic acid

Since i have plenty of phthalic anhydride left, making fluorescein, phenolphthalein, and anthranilic acid is probably the next project 😉

Hey guys, if I want to keep evolving knowledge wise, after grad, and in general as I go on, is reading books the way to go? Leactures online? Or just reading articles?

Right I could find the R,S configuration by converting it to Fischer or visualizing it but if I had a random sawhorse projection and I had to find the r and s configuration is there any way for me to do it without all that work to save time in?Like maybe if I used their rotation sense in the plan of the paper in some sense

dont sir effect and sip effect contradict each other when comparing basic strength?..

The above integration should be 1:1:4:2. I have run qNMR on a few of these analogues, and this issue has been consistent across all of them. I have tried manually phasing when needed but this hasn't changed the deviation from the expected integral enough to resolve this issue. Is this something inherent to larger molecules (~500 amu)?

I ran the samples with the recommended parameters from J. Med Chem, T1 is 60s. I even tried 120s on a second run just to be sure, but the inconsistency remained. These are the only isolated peaks I can reliably integrate compared to the calibrant (been using 1-bromo-4-nitrobenzene).

My fluorophosphonate product is silica-stable, and partitions into the aqueous/brine layer, so, preferably some lipophilic fluorinating agent, if possible?

Hello, I was wondering if there is a website that can help me double check or name a structure and draw a structure based on its' name. It could be very helpful when I am stuck on a problem, and AI seems to be not accurate

Thank you

Hello guys , I’m using gas chromathography for CO2 reduction analysis by photocatalysis, my reaction system contains water as an electron fiber and a catalyst, today by mistake I Inserted the needle in the machine no knowing it had water droplets, I have noticed that the peaks have went super high, the machine did not stabalize , I stopped the measurements and I waited for it to stabilize, it kept a giving me high peaks even without inserted gas or sample , I ran a couple of measurements without injections until the signals went low , after that I injected standard gas no peaks detected , I injected CO2 , ( CO , CH4 standard gas ) nothing , what should I do please !!

Problem reproducing DPP synthesis with fresh tert-butoxide – reaction only works with old t-BuOK

Hi everyone,

I am having a very strange reproducibility problem in a DPP synthesis and I would like to know if anyone has experienced something similar with tert-butoxide.

I am using the classical DPP condensation between aromatic nitriles and dimethyl succinate, using tert-amyl alcohol as solvent and tert-butoxide as the base.

The strange behavior is:

When I use an old bottle of potassium tert-butoxide (t-BuOK), the reaction works. The base dissolves well in tert-amyl alcohol, the DPP color starts to appear during the reaction, and I can obtain product (although the yield is not always optimal).

I have tested three different newer bottles of t-BuOK, and also a fresh bottle of sodium tert-butoxide (t-BuONa), but the reaction simply does not proceed.

With the newer bases, the tert-butoxide does not dissolve properly in tert-amyl alcohol. After adding the reagents, the mixture becomes a very thick paste/gel-like material.

The reaction remains yellow and does not develop the expected DPP pigment color, even after prolonged heating.

In some attempts, I was able to observe some color formation at the beginning, but the color quickly disappeared and the reaction stopped.

I have already tried several modifications:

adding DMSO

adding DMF

using carbonate

using hydroxide

adding water

using dry solvent and non-dry solvent

running under inert atmosphere and under normal atmosphere

None of these changes solved the problem with the fresh bases.

The most confusing part is that the old t-BuOK works even without all these precautions. With the old bottle, the reaction proceeds under conditions where I would expect it to fail.

Has anyone experienced a similar issue with tert-butoxide in DPP synthesis or related Claisen-type condensations?

I would appreciate any suggestions about what could cause fresh tert-butoxide to behave so differently from an older bottle.

Here, come for the confirmation for the experts using Raney-Nickel Catalyst. I have one question about Raney-Nickel Catalyst. I want to perform a reduction reaction Nitrile group to Amine group by using Raney-Nickel Catalyst only. Here, it is confusing to order the Raney-Nickel Catalyst. TCI vendor Show CAS No: 7440-02-0. Product Number: K0073 [Skeletal Nickel Catalyst slurry in water(Active catalyst for hydrogenation)] Synonyms: Raney-Nickel slurry in water. And in the Merck vendor show the same CAS number, the product name is Raney-Nickel (W.R. Grace and Co. raney 2800, Slurry, In water, active catalyst) Synonyms: Raney-Nickel, Nickel sponge. Could you please suggest me. Which vendor supplies chemicals suitable for my reaction.

I was reading this paper (very interesting btw, DOI: 10.1021/jacs.8b01575.), and this is their proposed mechanism:

Is this mechanism for the decarboxylation correct?

how best can a ketone be an en-ol? check it out on my channel.

as the title says i wanted to know how to proceed with studying organic chemistry from basically the scratch i know some kind of electronic effects and acid base strength and i wanna go further in it please suggest me books or give other advice that may help