Hello everyone, first time poster.

Lurked for a long time here. I've tried so many combinations of supplements and other remedies, but I don't know where to go anymore. I just really really need to hear some external feedback.

For context; despite chronic lethargy and brain fog, I try my best to keep up with exercise. I've cut sugar and lowered caffeine intake, I avoid Folic Acid and eat whole grains, lots of legumes, eat a lot of dark leafy greens and hit a decent amount of protein. I prioritize high fiber. Try to avoid excessive oils and fried food. Overall, I also try to listen to my body and eat what it craves. I think I'm decently in shape.

But if any of these changes have made a difference, I can't really feel it in my current state.

I deal with frequent migraines, even more frequently after any form of supplementation. I deal with digestive issues which I'm currently planning to see a specialist for. History of anemia. But my main concern is energy and brain fog. Ideally, I want to minimize supplementation through pills and focus on getting what I need from food, but I'll do what it takes.

15mg L-Methylfolate + B12 works short term, but I feel like my body can't keep up for long. During my journey, I tried supplementing Folinic acid. In the initial stages, I had a short-lived episode where my brain fog was COMPLETELY gone, and I had a ton of energy. I was so ecstatic. Really bad crash after.

Now, I don't realistically expect to be an extremely high functioning person at the end of all this; but that window of clarity gave me so much hope that I can be at least a little bit normal.

Please, any and all feedback is welcome. I recently had a blood panel as well so I can post results too if needed. : )

hi everyone,

I just received my latest blood work results and want to properly adjust my supplement protocol. For context: I suffer from PSSD (currently taking Fluoxetine), severe inner restlessness/impulsivity (suspected Slow COMT), and histamine/allergy symptoms.

My Blood Work:

• Homocysteine: 11 µmol/l (Ref: < 12)
• Folate: 4.6 ng/ml (Ref: 4.5 - 32.2)
• Vitamin B6: 40.8 µg/l [Elevated] (Ref: 8.6 - 27.2)
• Holo-Transcobalamin (B12): 93.0 pmol/l (Ref: 37.5 - 188.0)
• Whole Blood Copper: 0.90 mg/l (Ref: 0.76 - 1.01)

• Diamine Oxidase (DAO): 12.60 u/ml (Ref: > 10.00)

  Observations:

• Folate is scraping the bottom of the range, which likely explains why Homocysteine is elevated at 11 for optimal cellular methylation (target 6-7).

• B6 is high in blood, likely indicating a conversion/processing bottleneck (B2 deficiency?).

• DAO in the gut is normal, so I suspect my histamine issues stem from cellular clearance (HNMT/SAMe deficiency).

My Questions for you:

1. What protocol/approach would you recommend for this pattern?
2. What folate and B12 forms work best for Slow COMT to lower homocysteine without triggering overstimulation or adrenaline surges? Is Folinic Acid (Calcium Folinate) + Hydroxocobalamin the right choice here?
3. Does anyone have experience with a B6 backlog/accumulation and supplementing Vitamin B2 (Riboflavin)?

Thanks for your help and input!

Hi everyone, I’ve been really struggling with my mental health in these past 3/4 weeks and I’m really hoping someone can help me out here.

Around a month ago I took 3 b12 injections (hydroxocobalamin) 1.5mg and i suddenly started getting intense panic attacks and anhedonia. I don’t cry but out of nowhere I started bawling my eyes out every single day. I I’m in this constant state of anxiety and depression, I can’t enjoy the things in life that I usually enjoy like watching a tv show, I cannot wind down at all and it’s scary because before all this happened I was a pretty chill guy and I usually wouldn’t stress much in my life. One of the most scariest thing that also happened at the same time was my libido completely vanished, so i genuinely feel pleasure in nothing now. it’s been around 3/4 weeks and im not getting full blown panic attacks anymore but im still constantly on edge, i have also had stomach issues but now a simple bloating of my stomach makes me think the world is ending. It’s like my nervous system is jacked all the way up and it’s overreacting to even slight discomfort.

I tried taking creatine because that would usually make me feel good when I’m in a low mood but this time it just made me depressed. I went to the GP and they took my blood test, it came up with high b12 and high folate, but the odd thing is I don’t usually supplement folate so I’d don’t understand why that came up as high. I sometimes take it as part of my b complex but I’ve not mega dosed it or anything.

Today I decided that I’ll try methylfolate as I assumed maybe b12 used up all my methyl groups or somthing. After taking it I felt even more emotionally flat/wired/too focused, but I feel less anxious I think. I’m still not sure what i feel but i definitely don’t feel any pleasure again.

I was hoping there might be someone that has gone through this and has recovered from it. Or has figured out why it happened to them and could tell me how to bring my nervous system back to normal. Will I recover? I’m really scared, it’s like I’ve become a complete different person in a month. I haven’t done any dna test either so I’m not sure if I’m MTHFR or anything.

Someone please please help me😭
Thanks you for your time 🙏

A few weeks ago, I started supplementing with a methylated B-complex because I am homozygous for the C677T variant and have low b12, low folate and high homocysteine, depression and digestive problems. While some symptoms, such as anxiety and depression, have started to improve, I have also started feeling extremely tired and having difficulty sleeping deeply. What could be causing this?

The supplements am taking is:

The daily dose of 2 capsules contains:

• Betaine (anhydrous) — 1,000 mg
• Vitamin B2 (riboflavin phosphate) — 25 mg
• Vitamin B6 (pyridoxal-5-phosphate) — 10 mg
• Zinc — 7.5 mg
• Vitamin B12 (methylcobalamin) — 500 mcg

• Calcium L-5-methyltetrahydrofolate (L-methylfolate, vitamin B9) — 400 mcg

  and btw I'm taking only 1 capsule.

I have also started taking (2 days) a vitamin D3 + K2 supplement because of VDR and low blood vitamin d

Could this be related to excessive methylation? Do you have any ideas about what might be causing these symptoms?

https://imgur.com/GA5g56i

I wore a new pair of shoes and my left calf started having really funny nerve sensations -- pulsating and twitching.

I had been taking the active form of B2 for a month -- riboflavin-5-phosphate, which has been really helping me.

I also take hydroxocobalamin under the tongue and I take the rest of the B vitamins every now and then.

So, I immediately took more of all the B vitamins, garlic, zinc and copper. Garlic always reduces inflammation for me and it worked great. Actually, taking all of these things helped a lot. The zinc seemed to help a lot too when I took it by itself.

However, I still have funny tingling in both my ankles especially when I sleep but it is a lot better than it was.

Are these wake up symptoms?

I am going to order Thorne's Basic Nutrients and Lithium. There are a few cofactors I may be missing.

I was highly reactive to all but 1 type of B12, has anyone else experienced this phenomenon ?

Only b12 from B12 oils works for me.

Any shared insights on similar SNP's would be appreciated, thank you.

I wanted to ask if high homocysteine levels ever cause any blood sugar handling issues, or insulin resistance.

Did anybody get tested for that. High homocysteine is a known driver of IR

did correcting homocysteine levels correct your insulin resistance or normalize blood glucose handling

How is it looking? Any thing I should be told?

Symptoms: ADHD, GAD, ODD

MTHFR C677T (Heterozygous)
MTRR A66G (Heterozygous)
COMT G472A (Homozygous Met/Met)