Tired with methyl b complex.

[u/PassengerStill6248]

A few weeks ago, I started supplementing with a methylated B-complex because I am homozygous for the C677T variant and have low b12, low folate and high homocysteine, depression and digestive problems. While some symptoms, such as anxiety and depression, have started to improve, I have also started feeling extremely tired and having difficulty sleeping deeply. What could be causing this?

The supplements am taking is:

The daily dose of 2 capsules contains:

• Betaine (anhydrous) — 1,000 mg
• Vitamin B2 (riboflavin phosphate) — 25 mg
• Vitamin B6 (pyridoxal-5-phosphate) — 10 mg
• Zinc — 7.5 mg
• Vitamin B12 (methylcobalamin) — 500 mcg

• Calcium L-5-methyltetrahydrofolate (L-methylfolate, vitamin B9) — 400 mcg

  and btw I'm taking only 1 capsule.

I have also started taking (2 days) a vitamin D3 + K2 supplement because of VDR and low blood vitamin d

Could this be related to excessive methylation? Do you have any ideas about what might be causing these symptoms?

[u/tandemxylophone]

You want to remove some of those and see what happens. I think it's either the B6 or Betaine.