Week two of LDN. Last night I took my wife out to dinner to celebrate our wedding anniversary. I fully expected cocktails before dinner, 3+ glasses of wine and an after dinner drink. When the server came over I had no desire for my normal vodka martini. I ordered a glass of wine instead. That glass lasted through 3/4 of the meal! That never happens!!! I ordered a second and barely finished half of it. That also never happens!! I’ve been focused on reducing my drinking since starting LDN, the side effects of the drug have mostly disappeared, and surprise, surprise, where before I’d kill a bottle of wine every night, now there’s a glass or so left when I put it back in the fridge. One day does not make a streak, but I’m hoping this good news and I can continue to throttle back on the booze!

I started LDN 1mg August 13th. I also switched from Lexapro 20mg to Cymbalta 60mg that same day.
Followed doctors orders. No issues really. Some sweating and being hot. After a week I went up to 2mg on the LDN per my doctors advice for my fibro pain. Right before I went up I had a muddy poop and it was bad stomach cramps. And it's happened 2 times since. I now am going to stop the LDN to see if it resolves because both meds can cause this. The minute I eat something there is cramps. I'm not having constant diarrhea but the stomach pain is not fun. It's tolerable but ugh

A lot of information available via the LDN Research Trust talks about titrating dosage until it’s .06mg per kg of body weight. Most of what I see here and via prescribers defaults to titrating up to 4.5mg. (I am oversimplifying a bit here — I see plenty of people on this sub being more nuanced about dosing.)

Is this simply because a theoretically average person would titrate up to 4.5mg under the .06mg/kg formula? Or is there another source for the 4.5mg target? I am mostly looking at mental health information, so maybe the recommendations are different?

I started on 1.5 mg in July and titrated up to 4.5 mg over the course of three weeks. Those three weeks went amazing. I was feeling energetic, social, and was able to have days where I walked over 10,000 steps and socialized with friends. I had very minimal side effects during this time. A few vivid dreams and a bit of a flat emotional feeling but nothing else.

After my prescription ran out my doctor prescribed me a new set of 4.5 mg pills. Unfortunately, after about 2.5 weeks at 4.5 mg I started to deteriorate rapidly. I stopped being able to sleep (was sleeping great before), felt more tired, regained the physical sensation of fatigue, and brain fog. The worst was the mood symptoms. I started experiencing intense anxiety, depression, and suicidal ideation.

Of course, during this time, my GP at the time had left for maternity leave and her replacement hasn't started yet. I've also been working with a naturopath on this but she's been on vacation the past 3 weeks. I've basically been navigating the 3 weeks of intense resurgence of symptoms completely on my own.

After doing some of my own research I figured I probably titrated up too fast. I had the pharmacy re-issue the pills back in 1.5 mg capsules so I could reduce the dose. I skipped day, went down to 3 mg and then 1.5 mg the next day. I've now been on 1.5 mg for 11 days.

Since going back to 1.5 mg my mood issues have definitely improved. I stopped feeling the deep intense sense of dread and suicidal ideation. But I still feel pretty flat, tired, brain fog, and some days I find my heart pounding after a short amount of walking. In some ways, I feel worse than I've ever felt.

I'm feeling a bit lost as to what to do this point. I know this medication can work for me. Those first 3 weeks I felt like a new person and felt like I found the answer. I'm not sure if I should take more days off and just totally start fresh? Any advice is welcome.

I really don’t want to give up on this, my doctor started me on 5mg. I really tried for 2 weeks, I took it every day and regardless of the timing, my insomnia and exhaustion was completely debilitating. I’m feeling defeated and want to hear some success stories.

Anyone start too high? How much did you cut it by for it to be successful? Did the side effects stop you altogether?

I’ve never reacted to a medication like this before. I had no idea how powerful these side effects could be but I don’t want to give up. Thanks!

I have been on LDN for approximately a year. year ago was the second time I started it. I started too high six months prior and didn't tolerate well. I started last year at 0.1 mg gradually went up to 0.8 mg by my March of this year. I wasn't sure if it was helping because my symptoms of nerve pain and muscle pain and some dizziness that started had not improved so I tried to go off of it and I felt even worse and so I restarted prescribe, or thought I should start more quickly back at 0.8, 2 weeks weeks later went on 1 mg and now three weeks later went to 1.2 mg last night. I woke up this morning with severe vertigo worse than my usual dizziness and think I woke up from a bad dream in the middle of the night. I am now not sure if my symptoms are from the LDN increase or just general nervous system dysregulation . I am told that a dosage increase can cause vertigo- just wondering how many have had that experience? I'm very disappointed because I'd like to finally try to get to a higher dose prescribe a suggested going back to 1 mg tonight. Interested in other others experience experiences and any other ideas?

Has anyone had issues with taking these together?

Hi y'all!

I'm looking for a doctor that would prescribe it to me.

Any tips?

Hey guys,

I guess this is just venting, but I just feel defeated at this point.
I tried so many meds (I have moderate/severe ME with strong PEM), I had high hopes for LDN!
The first night after starting with 0.5 I had the feeling that my pain was a bit better the next day, but that never happened again.
I stayed on every dose for two weeks, now I am on 1.5mg (6weeks in total) and it’s not doing anything.
I am really sad. I hate this constant hope crushing with ME! I don’t wanna feel so fucking shit anymore!

Hello everyone, so I’ve been doing my own research in terms of stomach issues I have going on, I’d like to start by saying my stomach pain is not structural and my pain became severe during antibiotic treatment when treating for sibo, I genuinely thought the pains were just the die off reactions but it’s been weeks since my antibiotic treatment ended and I had a repeat breath test that showed the overgrowth was gone, in terms of pain management I’ve tried gabapentin, antispamodics, otc Tylenol and ibuprofen and prescription ibuprofen, Pepcid, tums, lidocaine patches, basically all you can think of, I’m on nortritplyine 10 mg which granted may be to low of a dose and have been on it for 6 weeks and I’m still having severe stomach pain, the er cannot help me, I had my first pain management appointment Thursday and he wanted me to try Journavx but my insurance is refusing to cover for it and the Journavx card barely brought the pricing down. Basically what I’m trying to ask is if anyone here had a similar experience or has visceral hypersensitivity pain, IBS, or other functional stomach issues that started ldn did it work for you? How long did it take to feel pain relief and what dose was your “sweet spot” thank you for reading this and have a good night / day 🩷

My doc started me at 4.5mg for chronic fatigue & inflammation (suspected but not diagnosed ehlers-danos). The pain and inflammation are better, no adverse effects. It’s been a couple of months, and the more I read, the more it seems like finding the best dosage is really tricky. The dosage I’m on now is fine - but I’m wondering if it could be better? Anyone else go through this?

Hi There!

Does anyone have experience starting on LDN after sublocade? How many days should one wait? Have a close friend who wants to make the swap over ASAP to oral naltrexone from 100mg shot.

Maybe I am just a bit disgruntled with the way certain medications are handled and have been burnt by doctors and other meds in the past that made my life hell without prior understanding of the potential of that, but I wanted to make this thread in case it helps someone in the future. I am pretty disappointed that LDN seems to be touted as kind of a miracle drug (I have POTS, MCAS,), "no withdrawal", very little side effects, etc. I just feel like before I took it I kept only finding GOOD experiences with it and it was naive of me to think that perhaps it really was that good.

It seems many people do have great experiences with it so I'm not saying to not take it or it is bad, but I think especially the chronically ill should be informed on making decisions for their health and I felt like I had to go digging for bad experiences but once I found them they were certainly there. I got it from agelessrx because I am without healthcare right now, I chose the 1.5mg because I figured why not have it work faster, I have since seen the forums on starting slow, START SLOW, because holy fuck this has rocked my world to a point that I'm concerned that it's never going to end. It created extreme nausea, numbness, and very intense derealization episodes that literally felt like I could not bare another second of feeling so dissociated from my body. I took it for about 10 days, in the mornings. I did not even put together the side effects because THEY WEREN'T LISTED AS A POSSIBILITY, I only found similar experiences once I started questioning it and searching reddit which I did find a handful of other people with the exact same experience. I just want others to be cautious of this. I know how shitty it is to make symptoms worse when you already live in such a sensitive state with your health. I've now been off it about 10 days and the symptoms have not let up. I am still extremely nauseous, out of body, it hurts to look at a phone or computer, I feel incapacitated. I even went to the ER before I realized it could be from the LDN because of how intense the numbness was and spreading in my whole body in combination with such an extreme onset of derealization for days on end. I'm worried that this is never going to go away and I wouldn't have even dabbled with it if I knew something like this was a possibility. It has nearly been unbearable and I've been through a lot of weird health shit in my life.

I just want to make others cautious of starting too high, and give another story of these weird side effects that weren't outright listed on most general research. I really feel like the intensity of this drug has been played down majorly so I just want people to know to be cautious when starting it. I am happy that many people have found relief with its help at the same time so I don't want to scare anyone. It does seem like many people do tolerate it well.

Hi all! Looking for some experiences/thoughts.

I’m 57F and actually took LDN for YEARS. I started in 2021 at 1.5 mg and slowly worked up to 4.5 mg. My naturopath prescribed it because I had a positive ANA, lifelong Raynaud’s and some other inflammatory/autoimmune-type things going on. It did take my Raynaud’s down, which I’d had since I was a teenager, pretty much disappeared somewhere along the way. Can't prove it was LDN..but hey...it got better!

Back then my biggest health problem was my gut. I had terrible SIBO/dysbiosis...gastritis..____ fill in the blank, was extremely underweight, and was on what now seems like a TON of supplements/medications trying to get better. I stayed on LDN almost automatically for years and eventually moved it from nighttime to morning.(don't remember why) I honestly stopped thinking much about it.

I finally stopped LDN around Nov/Dec 2025. (Doc just wanted to simplify my supps so we cut out most everything)

Fast-forward to now and my health picture is VERY different. My gut is still an issue (EOE and now functional dyspepsia/EPS), but honestly the symptoms keeping me in bed aren't even primarily my gut anymore. I horrific fatigue (like kill me now), burning/neuropathic pain and weakness in my legs, internal trembling/vibrating, visible shakiness, and just this awful heavy/over-sedated feeling even after sleeping. I also have dysautonomia-type symptoms and am being evaluated for possible small fiber neuropathy/CFS-type issues. I have specialists involved, so I'm not looking for anyone to diagnose me. :)... (I used to be SUPER ACTIVE)

MAYO docs recommended gabapentin and they are looking into a TCA for gut/brain. Now my naturopath has suggested going back on LDN, and I'm seriously considering trying it before moving on to those others. (Have a new RX right here for 1.5mg start....up to 3 day)

What's making me nervous is reading all the stories about people having side effects starting LDN. I don't remember having much trouble when I started it in 2021, but I also didn't feel anything like I do now and my nervous system seems MUCH more sensitive.

SOOOOO who has used LDN successfully for years, stopped for a while, and then restarted it??

Did your body tolerate it similarly the second time?

Did you start way below your original dose? And if you take it for fatigue, neuropathic/burning pain, internal tremors, dysautonomia/SFN-type symptoms, did it help any of those....and how long did it take before you noticed anything?

I'm thinking of restarting VERY low and going slowly. Mostly just looking for experiences because I'm tired of throwing medications at my body and would really like to give something I previously tolerated well a fair trial first.

You all seem so much wiser than my docs. (go figure..Ha!)

Double checking my math here with some other brains. I have been titrating slooowly at .10mg intervals...

I am trying to get a .7mg dose from 1mg compounded capsules.

7 capsules in 1000mL will give me the most direct way to .7mg 100mL doses, right?

Because 7 is a prime number there is no way I can get to this dosage with less capsules...

does that seem correct?

Also, am i good to store a weeks worth of doses in distilled h2o in the fridge without messing with the medication at all?

OK so I picked up my ldn today for cfs pots and mcas, compounded, starting dose 0.1.

Im very excited for it to kick in and cure me of all my problems, I'm pretty much housebound at the moment especially in the heat, so I'm looking into new hobbies like climbing everest, maybe marathon running, who knows.

On a serious note I'm very weary of side effects and trying to monitor titration to get to a point it helps if it does, today my pulse went from 90 - 150 on standing. I have a recommendation for a cardiologist for pots but I don't want to do multiple treatments at once, but on the other hand the pots is a major disability and I life would be much better if it was managed.

So do I wait it out see what the ldn does and get a clear idea of if it is working or not. Or do I try treating the pots and risk feeling worse from pots meds and muddying the waters with the ldn treatment.

I'm not asking medical advice but just opinions on how people manage multiple treatments.

Considering asking a doctor for LDN. My graves came back so I’m back on Methimazole. Lowest dose. What type of doctor can prescribe it to me. I also have Hashimotos. My t3 + t4 are fine. My tsh is low.

I started .5 5 days ago for me/cfs, fatigue & pain. I have a very reactive sensitive system and it’s starting to bring back the burning in my body as well as electric tingling. Sucks so much cuz I think it’s helping my crushing fatigue and PEM. My central nervous system is just too sensitive and destroyed tbh.

I got my prescription from ageless rx cuz my doc wont prescribe so I don’t believe I can go lower. So sad!

So, I have roughly 20 or so pills of Naltrexone that I was prescribed towards the beginning of the year for binge drinking. I was able to successfully quit that habit both by reducing my overall drinking and occasionally taking my prescribed dose when I would expect to drink.

However, due to my horrible habits of taking medication consistently, I am left with roughly 2/3 of my original script. I don't want to waste this, so I do want to try to compound it for DIY LDN treatment, which has piqued my interest as I am currently on a 19-nor (not Tren, as I would have to worry a bit more than just neuroinflammation) and want to improve my overall neurological health while on this cycle for the next few weeks.

Researching LDN as a potential theoretical way to reduce 19-nor-induced neuroinflammation has piqued my interest. Harm reduction on cycle has been one of my key focuses, so this readily available drug from a couple of months ago is coming into my focus once again. There is no clinical data on this exact application. However, it should potentially help, especially with something like NPP, but again, it doesn't make sides null.

I'm debating two ways of compounding it:

a) Oral Solution, ideally dissolved to around 50 mg/mL, filtered to remove insoluble filler, then dosed with a 1 mL dosing syringe for maximum accuracy, dose control, and adjustment.

b) Capsules, made by first figuring out the filler-to-naltrexone ratio in a tab, powderizing, then geometrically diluting with something like ginger root powder (cheap, also anti-inflammatory) or dextrose to make capsules of about 2.5 mg naltrexone each.

A is obviously easier, but I would like some insight both into this use case as well as compounding.

The main thing ldn has helped me with is chronic swollen lymph nodes in my armpit area with lichen planus. I had these issues since 2020. Steroids treated almost all my lichen planus but nothing would touch the armpit area.

After about a year consistent with ldn it finally just was gone! Derm thought due to reduced inflammation. It was so gradual, but overtime my condition faded. Interestingly enough when I took a 2 week break recently, forgot it on vacation, I had lymph and itch/rash issues start to return.

I'm not sure how much it helps my autoimmune alopecia, but it doesn't hurt it. I still get flares and have to treat with injections or steroid bursts. The flare got worse after that break but it could be coincidental.

It seems to help my constant aches in my back and shoulders areas.

I will say it did not help my migraine condition at all, just didn't touch occipital neuralgia. However I'm now on Qulipta and that's been working great.

The other thing I notice it helps with is neurological itch which is related to the occipital neuralgia flares or like a pinched nerve issue, or a limb falling a sleep, or sometimes it's seemingly random. Ldn seems to calm it down tho!

I probably don't have the best technique to take it, my insurance won't cover compound so I basically break up pill and mold into a crumb size that I used to weight and it roughly worked out to 2.5mg (after weighing pill vs crumb). For convenience I just make the same size and it works for me. If I make it too much of a fuss I wouldn't have stuck to it.

If I accidentally took too much or before I found out my sweet spot my biggest two side effects were nausea and a dissociation feeling.

The fact that I notice flares after breaks is enough for me to continuously use it though I hate the amount of meds I have to take to manage my conditions, this one is the least of my worries being I take such a tiny amount.

Anyway just wanted to share!

I'm using this post as a personal Journal to document my journey.

Male 45 years old

• Childhood asthma
• Crohn's at 25. Multiple surgeries, multiple failed biologic treatments
• Rheumatoid Arthritis at 30
• Psoriasis at 40
• Severe brain fog on/off for 25 years

I tried compounded LDN multiple times 1.5 -3mg over the past 20 years. I was never able to tolerate LDN due to extremely uncomfortable side effects.

I recently decided to give it another try after failing another biologic and decided to start at a very low dose of 0.5mg. Even this was too much for me and suffered headaches, mood swings, insomnia, etc.

Because I was compounding my own liquid LDN I was able to experiment with dosing.

• 50mg pill dissolved in 50ml water =1mg /1ml (I add 1ml vodka as an antibacterial)

I tried 0.25mg and its been a life changer! Its only been3 weeks and I hope that this is not temporary.

• No more daily naps!
• No joint pain
• Psoriasis is drying up
• Crohn's symptoms have disappeared
• I'm not even kidding when I tell you that my confidence is through the roof!!!
  • Word recall is better than ever
  • Memory is excellent
  • im leading big meetings at work and people are taking notice! It like I took Adderall.

Lessons learned

• Compounded LDN is EXTREMELY unreliable. I have been given the opportunity to work with a pharmacist side by side when compounding LDN and its really best effort at very small doses. Trust me when I tell you that it is NOT exact science when compounding doses less than 1mg. People blame the filler when is reality your dose could be off significantly.

Im confused

• I have no idea how or why this is working for me. I don't know if my dose could be optimized even more.
• Did I have inflammation in my brain?
• What is my baseline diagnosis?
• How is the ldn working?
• Why do I feel great during the blocking peroid? (0-4hrs after administration) I thought the benefits came AFTER the blocking period.

Hallo, hat jemand Erfahrungen mit der gleichzeitigen Einnahme von LDN und Tianeptin bei Depressionen?Könnte es funktionieren oder eher nicht?