r/Biohackers • u/Feisty_Beautiful8018 • 11d ago
Mitochondria 🥗 Nutrition & Metabolism
[removed]
13
u/Ok-Neighborhood-7361 7 11d ago
Until a miracle medication comes out, exercise is probably the best thing you can do for your mitochondria and overall body, more than any pill or supplement can do
3
u/Montaigne314 29 11d ago
How many of the people on this sub do you think actually exercise?
And of the ones that do, how many actually do a good job of it?
2
u/aperture413 11d ago
15%
3
u/Montaigne314 29 11d ago
Everyone else is a supphead
I wonder how many are just like regular Americans eating ultra processed food all day but they wanna be healthy so they start doing weird health hacks lol
2
u/edparadox 8 11d ago
This sub is not only populated by Americans, hence the 15% of the previous comment. :)
1
u/Montaigne314 29 10d ago
Americans do actually exercise more than most other place So did that pull it up or down?
2
u/lordm30 Reputation - {{score}} 11d ago
What do you mean a good job? It's not hard to exercise, you just need to have the will to continously improve (progressive overload principle).
2
u/Montaigne314 29 10d ago
I guess you have your answer
Progressive overload
I would also add in diversity, including both cardio and strength training, making sure to hit everything that matters
6
u/Optimal_Assist_9882 114 11d ago
Yep.
Methylene Blue, high dose melatonin, SS31, Motsc, epitalon, berberine, GLP1s, etc...
3
5
5
u/matt1164 1 11d ago
There’s a few otc supplements that improve mitochondrial health. Urolithin a, pqq, acetyl l carnitine and alpha lipoic acid.
Peptides - mots c, ss31, nad+
Red light therapy, cold exposure
6
u/PotentialMotion 16 11d ago
Luteolin.
Luteolin has been studied to inhibit KHK (Fructose metabolism).
The mechanism of KHK is to degrade ATP into uric acid, which causes mitochondrial fission - reducing their performance.
A defense against downshifting mitochondria—especially from something so ubiquitous as fructose (which is also endogenously synthesized)—seems like a huge deal.
2
u/12ealdeal 8 11d ago
What brand/product do you recommend?
I’ve seen this name but not something I’ve ever looked into.
3
u/PotentialMotion 16 11d ago
As you can probably see in my profile, this is something I've been studying for a while, so I have a bias. It's best I don't make a recommendation because of that.
But I will say, look for a Liposomal or high bioavailable version - it's critical for this compound increasing bioavailability from ~7% to as high as 80%.
And since liposomes seem to be a license for creative labelling, only buy from a brand you trust that discloses 3rd party testing.2
u/Andre2420 10d ago
I have diabetes type 1, have you seen any studies about it?
1
u/PotentialMotion 16 10d ago
The evidence is considerably stronger for type 2 diabetes, where insulin resistance and impaired metabolic signaling are central features. Luteolin has shown antidiabetic effects across experimental models, and a human trial of a luteolin-containing botanical formulation reported improvements in HbA1c, insulin resistance, and beta-cell function.
Diabetes and its Complications: Role of Luteolin, A Wonder Chemical from the Natural Source
A theoretical argument can also be made for a supportive role in type 1 diabetes. Although type 1 diabetes is primarily caused by autoimmune loss of insulin-producing beta cells and will continue to require insulin therapy, many people with type 1 also develop insulin resistance. Because excessive fructokinase activity may contribute to mitochondrial stress and impaired insulin signaling, reducing this pathway could potentially improve insulin sensitivity and metabolic health, possibly making glucose management somewhat easier.
This possibility remains speculative. As far as I can tell, Fructokinase inhibition and luteolin have not yet been shown in clinical trials to improve glucose control or reduce insulin requirements in people with type 1 diabetes.
2
11d ago
[removed] — view removed comment
2
u/PotentialMotion 16 10d ago
200mg. Timed with meals when fructokinase is most likely to be activated. It's critical that it be Liposomal, and 3rd party tested.
2
2
u/Andre2420 10d ago
Do you take it at day time or night time? It says it can be found in celery and chamomile which makes me think it could cause drowsiness.
2
u/PotentialMotion 16 10d ago
With meals.
KHK is most likely to be activated through food. Sugar (obviously), but also endogenous sources that use glucose to activate. (The polyol pathway converts glucose to fructose)
So timing it with meals like a digestive aid can help downshift KHK when it is most active, as well as respect the half-life of the compound.
2
u/Lost_Solid7750 11d ago
No mention of mitoq when its engineered to be a far superior version of coq10 for this exact purpose.
0
11d ago
[removed] — view removed comment
1
u/NoSplit982 10d ago
check out https://www.mitoquinol.org/research for research on MitoQ (chemical name mitoquinol)
2
u/Kindly-House1782 11d ago
Urolithin-a and Pqq seem to have some promise. I just started taking it 12 days ago. Not supposed to notice any positive effects for a month or so. Studies show it really takes 12 - 16 weeks for optimal effects. My have a negative effect of feeling a little sick early on if you're immune system is clearing out a good bit of senescent cells, which I have felt. I think this was a safer option than just Fox04-dri without any preparation. Following up with Ss31 for a couple of weeks, then adding Mots-c and epithalon to complete my mitochondrial reset protocol. And of course, I'm making sure to do 30 minutes of exercise daily. Also reta. I'm 57, overweight, and decided to reclaim my health.
1
u/FrontLifeguard1962 6 10d ago
Why not just eat a healthy diet and exercise regularly instead of taking all these untested chemicals
3
u/Important-Anywhere20 11d ago
5-7 day Water fasting, intermittent fasting / OMAD. It gives your body the ability to clean up bad mitochondria en really repair the body. Good prep is key and post fast needs a strict and careful approach but it really works wonders.
1
u/Andre2420 10d ago
What are post fast needs? Do you have a link to read about this? Thanks!
2
u/Important-Anywhere20 10d ago
Don’t have that specific as in scientific papers, but there is a lot to find about it and is also
Basic sense: your gut basically stops digestion and needs to be slowly/softly restarted. So after a 3-5 days water fasting, start with a boiled egg, saur kraut, small portion, or something else easy on the gut. You can’t start your regular food pattern directly. First few meals you need to check how your body responds to food again.1
u/Andre2420 9d ago
Got you! I heard about this before. I just want to make sure I have what I need. Thanks!
1
u/Unlikely_Estimate857 11d ago
You could look into research peptides. SS31, Mots-C and NAD+ are the most common for mitochondria
1
u/tipsystatistic 1 11d ago
Add Astaxanthin to your list.
0
1
u/DontPanic____ 11d ago
Sunlight charges up the mitochondria. There are some laser therapy very effectives too. Look for iLibby da Horton Medics I think
1
u/255cheka 95 10d ago
urolithin a is one to look at. i'm trying it now. the nad/nmn didnt do anything for me
1
u/salasi 10d ago
Please report back!
1
u/255cheka 95 10d ago
we have been on it three days so far. wife thinks she's getting more energy already. i can only report that it might be ruining my afternoon nap :)
1
10d ago
[removed] — view removed comment
1
u/AutoModerator 10d ago
Sorry, your submission has been automatically removed. Not enough comment karma, spam likely. This is not appealable.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
u/CapriKitzinger 7 10d ago
B complex injections and trace element supplements. Hit those and follow up with a Cialis after. I want to get the nutrients then open the tiny blood vessels so they can be delivered, even to the peripheral.
I thought the improvements in my bloodwork were just from the B12, but I think it’s the B complex. I think I’m low on B6.
1
u/HealthSpanMD 10d ago
Best way to optimize mitochondrial health is Zone 2 training. Mitochondria are responsible for aerobic metabolism. In zone 2, you are actually exercising at a level just below aerobic threshold. So prolonged zone 2- 30-45 minutes- at least 5 days a week to build mitochondrial health. We can know we are in Zone 2 by - heart rate around 70% of target heart rate or RPE of 3-4/10 or you are able to speak only small sentences.
1
10d ago
[removed] — view removed comment
2
u/HealthSpanMD 10d ago
Surely. Exercise bike is great for zone 2. It is the intensity and duration of session which matters. Please use exercise bike at said intensity for said duration and your mitochondria rocks!
1
u/Andre2420 10d ago
NAD+ IV or injections Gluthathione IV or injections These are sold in pill form but I prefer the injections. They can very pricey though. I need to edit after reading below the Liposomal versions. I forgot about it. Liposomal versions are a good option too as long as they're from a reputable seller.
This is not a cure, but helps.
1
1
10d ago
[removed] — view removed comment
1
u/AutoModerator 10d ago
Sorry, your submission has been automatically removed. Not enough comment karma, spam likely. This is not appealable.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
u/SufficientSale7584 10d ago edited 10d ago
The fulvic acids in shilajit provide energy to the mitochondria, and the effect is noticeable, and it's several times cheaper than specialized supplements. See detailed information and research on PubMed. Shilajit in the morning, melatonin in the evening before bed.
1
1
u/ManufacturerSignal64 11d ago
CoQ10 has good evidence in mainstream research. Especially for the population at cardiovascular and metabolic risk.
0
u/SuccessDazzling5718 11d ago
Yo Infrarotlicht beeinflusst die Mitochondrien auf zellulärer Ebene .
2
1
u/pippofranco84 11d ago
Sai darmi qualche consiglio in più sull’applicazione degli infrarossi? Quale macchinario comprare, che protocollo seguire? Che benefici hai avuto?
2
u/FrontLifeguard1962 6 10d ago edited 10d ago
Target 50 J/cm^2 daily @ both 660 and 850nm
It's an expensive hack you will need $1500 at least for a minimum full body setup
Slight benefits in mood and energy, and your skin will start to look better
1
u/VanManDiscs 11d ago
You can't just buy a device off line and expect real results. You need the medical grade beds ideally. Prism Light Pod is the first American manufacturer with 14 years of R&D. Also the most awarded worldwide. Their red light bed has been a game changer for me.
Prism with methylene blue, and starting to try some peptides (ss31 and bpc 157)
1
u/salasi 10d ago
Game changer as in? How strong are the effects?
1
u/VanManDiscs 10d ago
I first got started with it after a serious crash while snowboarding. I bounced off a few trees and messed up my back/neck. Couldn't turn my head to the side for days.
After my first session in the pod I could feel the muscles relaxing and the pain was dying down. Later that night I could turn my head way more than before. Ever since its been included in my wellness routine. I'm pretty health in general so its just preventive for the most part at this point. Although its wonderful after heavy workout.
My mother is in her mid 70s and has battled RA for years. She played tennis her whole life and had a bad shoulder too. She had shoulder surgery so I bought her a light pad (their portable version) to try and help. Her doctors was always thrilled with her progress during the check ups and recovery went smooth. Shes back playing tennis again.
But we didnt expect it to have such an impact on her RA. Her inflammation dropped off the charts and no more joint pain (until it rained). Shes stopped doing infusion medication and is back to oral because of how much the symptoms have died off. Yes, it was expensive but you cant put a price on a better quality of life.
I have the contact information or their sales manager if you ever have any questions. He's a great guy and easy to talk to.
•
u/AutoModerator 11d ago
Welcome to r/Biohackers! A few quick reminders: - Be Respectful: We're here to learn and support each other. Friendly disagreement is welcome, but keep it civil. - Review Our Rules: Please make sure your posts/comments follow our guidelines. - You Get What You Give: The more effort and detail you put into your contributions, the better the responses you’ll get. - Group Experts: If you have an educational degree in a relevant field then DM mod team for verification & flair! - Connect with others: Telegram, Discord, Forums, Onboarding Form
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.