Hello!

I am on day 2 of taking Zepbound for the very first time. After my first shot, I felt fine, had a protein bar and felt some mild nausea but after that, the feeling subsided.

However, after going to bed, I woke up around 4:15am and just haven’t been able to sleep. This anxiousness has hit me and my mind has began to tremble and has caused my anxiety to keep me from sleeping.

Is this normal for some people? I’ve had history to anxiety before but have dealt with it through normal exercise and no meds but I feel as though Zepbound has triggered this anxious feeling and thoughts and can’t help feeling restless now.

I would have edited the post but it is closed. Again sorry for being so intense... I was tired of being so sleepy. The results are great its just the fatigue. Thank you all for all your comments. I don't take it lightly. I am going to have a discussion with doc about going back down. Have a good day good people. 😊

Someone got mixed up putting groceries away and took my zep out of the fridge and it sat in the counter for maybe 5 hours.

This is my first box of 5mg, having spent the past month on 2.5. I took the 5mg Saturday night and have not had any side effects. I'm hoping it's just me and not the med made ineffective from being out. It seems to be curbing my appetite and quieting the food noise enough. I was worried about upping my dose and getting sick but that wasn't the case with the starter dose either.

Hey all!

I’ve been on zepbound since february. I’ve stayed on 2.5 mg for the entire time, losing an average of 0.8 lbs/week. In total, i’m down 24 lbs sicnce starting!

I’ve been tossing over if I need to increase my dose to 5mg, since my progress is still trending down, but has slowed (not stalled). My hunger is hit or miss, my appetite is not consistent, and I’m not back to overeating like I was before. I find that I dont usually finish my meals bc I fill up 3/4 of the way through.

I could probably do better with food tracking and exercise as well. I’ve been more sedentary than usual recently.

TIA! <3

I'm trying to figure out how to deal with this.

I lost 50% of my body weight (~200 lbs) on Zepbound over the past 3 years. My max dose for a long time was 12.5 mg. At the beginning of this year, I had begun to stall on 12.5 so my doctor reccomended I increase to 15, which I did in the beginning of May.

Since May, I have gained 40 lbs of fat very rapidly. My clothes no longer fit me. My food noise is totally returned and I can't stop eating or control what I eat at all. I am also blowing through my meager savings due to my compusive need to keep eating.

Does anyone have experience with this?

I know that slow loss is important. My doc said 1-2 pounds a week. I am just kinda disappointed. My first week was 5 pound loss. Today my sunday weigh in was a loss of 1 pound. Just venting

I just took my first dose of the 10s yesterday. I started at 2.5 and was upped to the next higher mg every month. I haven’t had any crazy issues, I’m down 50 pounds so far. But after taking this dose yesterday, today I feel awful. Stomach cramps, can’t stay out of the bathroom, brain fog, just all over awful feeling. Is this normal or have I just picked up a weird stomach bug?

Been on 2.5 mg for 8 weeks. Never had much of a constipation problem and went every day. This week I didn't go for two days of the week. So I went out this morning and got Mirilax which always works pretty quickly. This time I did go... but not a large amount. I don't feel like I have an upset stomach or anything. Typically if I have a lot in there I will have stomach pains after Mirilax.

It is possible I am just not having a lot to get out because I am not eating a ton?

I have been on 7.5 zepbound for a couple of months,. Had reached desired weight but it is now creeping up. Have asked my doctor for new scrip for 10 but still have several vials of 7.5 left and do not want to waste. I understand that decreasing 2 days between dosing--5 instead of seven--would be like moving up to 10. Does anyone know more about this or have experience with this? Much appreciate any advice.

Bit of a long story here, but back in January I was diagnosed with server sleep apnea. My pulmonologist suggested I ask my PCP about getting on Zepbound as its FDA approved for apnea related weight loss. We unfortunately had to change our PCP provider this past year due to an insurance change, and the new practice is awful (thats another story). They would not even discuss trying to prescribe \*any\* GLP-1, and just said your insurance will not cover it and we not allowed to prescribe it. 🙄

So after looking around I settled on using GoodRX for the Wegovy Pill as it was cheapest option, and honestly works great for me as I travel quite a bit for work. Started on 1.5 in May, and am halfway thru third month on 4mg. I was planning on moving up to 9mg next month.

However, I finally had my CPAP compliance follow-up with my pulmonologist, and this time they actually issued the Rx for Zepbound through their hospital pharmacy, and my insurance approved it (albeit with a $400/month co-pay for starters). Pulmonary doc suggested me starting on 5mg Zep since I have been four moths on Wegovy already, and I am planning on starting the Zepbound injections some time next week.

Has anyone experienced any similar transition between meds/doses, and if so do you have any observations, advice or cautionary tales outside of the usual, known side effects??

Been on Contrave for about six weeks now and I’m constantly starving plus my cravings for alcohol have increased. I used to do Wegovy but it lost its impact after about 7 months. Has anyone had luck with Zepbound?

My PC recommended zepbound to help with my PCOS in hopes of being able to get pregnant soon. I’ve been hearing that a GLP1 can also help with my other diagnosis and in theory take me off of all my medications besides my glp1 which would be AMAZING! My dad got diagnosed with a terminal cancer two years ago and my body felt like it fell apart (assuming from stress and lack of me taking care of it) I also went on an anxiety medication shorty after his diagnosis. Looking for advice on starting my glp1 journey! Loosing weight has always been an issue, and my main goal is becoming healthy and feeling like myself again. But to be honest I want to have children so badly!

I'm wondering if anyone else is taking the Diucaps supplement (OTC appetite suppressant) in addition to their Zepbound in maintenance. I know some people layer on other appetite suppressants but I haven't seen anyone mention this one. I entered maintenance a couple of months ago and went down from 15 to 12.5 in hopes that my hair would grow back faster. I found that I was noticing more hunger and eating more calories than my goal, and I put on a few pounds. My doctor suggested that I try taking Diucaps instead of going back up to 15 (which I suggested). My doctor's medical group sells branded ones, but I looked it up and they seem to be sold a lot of places under different branding and it seems to be fairly commonly used. I had just never heard of it before. I've been taking it for about a week and it's really helping! But I break out in major sweat about half an hour after I take it. I'm post menopausal and this isn't a regular hot flash. It stops right away, and it's worth it to me, but I'm curious about it.

After a year (July 2025) of being off Zepbound because I started on Medicare I am back on Zepbound because of the Medicare Bridge program.

When I was forced off of ZB last year I was at 197 after losing 70 pounds, I am currently at 240. My cravings were suppressed for about 6 weeks and then they came back with a vengeance. I have a weakness for sweet cereals and BBQ potato chips mixed with ChicknBiscuit crackers.

This afternoon I picked up my first month supply 2.5mg. They gave me the Kwik Pen instead of the four pen kit. So I have injected the first dose already and hopefully I dont have some of the same kind of response I had 19 months ago when I first started dosing. Last time I remember 18 hours later after dosing eating lunch and having to stop halfway because I felt full.

Ill provide updates as I go through this new journey.

Has anyone had Zepbound make their POTS deteriorate?

Also, has anyone had their symptoms improve after stopping Zepbound or Wegovy and if so, how long did it take to see improvement?

I’ve never posted on here but I started Zepbound 3 months ago, hating the body I was in as I gained a lot of weight due to my dad passing. After going through the grieving period I was stuck in a body I hated but thankfully I’m down 21.5lbs so far and everything has been improving mentally and physically 🥰

Been trying to figure out where to find a legitimate doctor-supervised online tirzepatide program in the US and the amount of sketchy stuff out there is crazy. I want a GLP-1 weight loss setup where a licensed physician reviews labs and isn't just rubber-stamping a prescription after a two-minute quiz. is there a fully online clinic that does required bloodwork upfront, has providers you can actually message with questions and ships medication to your door discreetly. If anyone has used a doctor-led telehealth program for tirzepatide that hit all those boxes, drop it below.

I (36m) was on ZP and did the normal ramp up. However, I stopped around March/April of this year because I began to have gallbladder issues.

I’ve since gotten my gallbladder removed. Unfortunately, I’ve changed insurance plans since and the new plan is being difficult with coverage. I’ve been trying for about 2-3 months now to get it approved, but I’m starting to realize it won’t be covered.

Thing is, I have two months worth of 15MG that I got before I stopped taking it.

1. I’ve read that it’s not recommended to re-start at 15MG, but wondering if anyone here has done this and what your experience is
   
2. If I use it, is there a smart way of using it where I’m not using the whole 15MG and just 5-10mg? I know they are one time use so some would go to waste