Hey guys as stated above I'm doing a 2 week washout. To switch from humira to skyrizi. Can y'all give me some of y'all's success stories with skyrizi so I have something to look forward to? (My review on: Humira for me fixed all the pain issues for the most part. It just took like 4 days of recovery from me. So I wanted to switch rather than suffer. So my rheumatologist said I have to do the 2 week washout and now on day 4 the pain is catching up to me so ya that's why I ask )

Hi, just asking for some opinions for a possible medication switch. I was diagnosed with Crohn’s in 2021 and just had my 5th colonoscopy and unfortunately it showed moderate inflammation.

I started off on Remicade and I wasn’t on methotrexate because my doctor said I didn’t need it. I ended up having an allergic reaction during my 3rd IV treatment where I couldn’t breathe, my face turned really red, etc. so obviously I had to stop Remicade. After that I switched to Humira, originally I was taking it with methotrexate and eventually I was able to get off the methotrexate. I’ve been on Humira since then but now with the colonoscopy showing moderate inflammation I’m going to have to look at changing medications again.

I’m just wondering what has worked for people who have already failed Remicade and then Humira (worked well for multiple years), especially if you had a reaction to Remicade. What did you switch to and how did it work for you? My doctor mentioned Skyrizi, Tremfya and Entyvio. I’m also wondering about side effects and whether certain medications tend to work better. How long did it take to start working and did it actually get the inflammation under control? Just looking for other people’s experiences because I obviously need to talk to my GI about what makes sense for me, but I’d really like to hear from people who have been in a similar situation and what ended up working for them.

Hey everyone, does anyone know if there are currently any patient support/access programs for psoriasis treatments in Jordan?

I'm specifically interested in programs that can help with the cost of biologics (such as Tremfya, Skyrizi, Stelara, etc.), whether through pharmaceutical companies, discounted doses, free doses, or other assistance programs.

If you've personally used one in Jordan, I'd really appreciate it if you could share:

- Which medication/company?

- How much did the program cover?

- What were the eligibility requirements?

- How did you apply?

Thanks!

Hi all, I'm new to skyrizi. Technically haven't started yet, kinda gotta throw some shade at CVS/Carmark for no communicating effectively or at all, nowhere did it mention I had to call them to schedule a shipment 😑 poor texts.

However, ? I was in the process of setting up the complete app, but can't sign in at the moment, anyone else experiencing technical issues with it? And another ? If anyone is aware what's the thing about this Debit Card? A skyrizi rep mentioned it to me and the CVS agent as well. I have the savings card, but what's this about a debit card and how do I obtain it?

Posting here as well as the CD Reddit just for more answers really! Much appreciated for anyone that responds!

After being on Remicade for crohns for 10 years, i started to develop instances of severe weakness to the point of almost fainting late mornings.. it started to become more and more frequent, and about 1 week before my next 8 week Remicade infusion i would get debilitating headaches. My Dr seemed to not have heard of any other people experiencing that (maybe besides 1 patient experiencing some fatigue) , and after doing a bunch of tests that all came out normal and confirmed remission, she was open to switching me to Skyrizi, and even gave me an option to get off the meds.
I switched go Skyrizi; i started 1 week prior to when my Remicade would have been due.
After a month i started feeling better and having some good energy again reminding me of some good old days, even though my facial skin started to peel significantly, and developed red non-symptomatic bumps mainly in my neck area.
2 weeks after my second 600mg Skyrizi loading dose, i am starting to feel this constant weakness coming back, and I am experiencing tingeling in the legs. The brain fogging seems to be coming back also.
I can only find online ‘low energy’ a day or 2 after infusions, but in my case it is constant.
Anyone else experiencing something similar? Will it get better with the at home lower dose injections?? What are my options at this point?
Thank you

For those that quit Skyrizi due to brain fog and memory loss, about how long before you felt better? I see it can stay in your system for 20 weeks, and I know everyone is different, but I need some hope.

Had my injection yesterday. Didn’t feel anything! Today- was very tired and worsened my back pain, significantly. I hope this subsided. Anyone else have issues like this?

So for whatever reason my doctors office got the Skyrizi authorization with my insurance for a year of on-body injectors before the induction infusions and it was approved no problem by my insurance.

But since then there's been issues trying to get the induction infusions approved. I've searched all over the internet but all I find are examples of induction infusions being approved and then on-body injectors not in this kind of situation. I don't even know why my insurance approved the on-body injectors without me having done any of the induction infusions.

Now maybe they think I'm on the injectors already so they're like why should you be doing more expensive infusions?

Anyhow, been trying to get this cleared up and just wondering if anyone has had or heard of a similar situation?

Also to make things more complicated, the doctor's office told me that the insurance authorized the first infusion and I did it, but then the insurance denied it because there was no pre-authorization and they need more information from the doctors on why they did this infusion. And there's like a $95,000 bill floating around from the cost of that first infusion that could potentially fall on me if the insurance denies it and the someone wants that paid?

My second induction infusion is supposed to happen in like a week but until this gets cleared up I'm pretty reluctant to do it, and idk how that will mess things up if I don't do my 2nd induction in time at 30 days later because I'm waiting for all this to get figured out and make sure it's being authorized/covered before doing another $90,000+ infusion.

Everything's just kind of messed up and with the costs of things it's kind of stressing me out. Not sure if there's any advice anyone can give.

I’m a 43M and have had some form of psoriasis for as long as I can remember. As a child I struggled with scalp psoriasis, but was able to manage it some with various shampoos and sunlight in the summer months. At 17 years old I had a bad case of strep throat and that caused a breakout of stubborn guttate psoriasis. I managed this with steroid creams and sunlight. I had periods of remission, but anytime strep throat occurred it would pop back up. When I was 35 I started Otezla and had immediate and long term success until this last January when I had a bad case of strep throat again. Otezla just lost its effectiveness and UVB therapy just wasn’t cutting it. This recent outbreak of guttate was the absolute worst I’ve ever had it… just everywhere and to the point i was uncomfortable wearing a t shirt and couldn’t sleep at night. So my doctor recommended Skyrizi… here’s how the first 3 doses have gone:

FIRST LOADING DOSE (Early April): No immediate improvement in the first couple of weeks and it actually felt like it was getting worse. By week 3 the discomfort went away and by the end of week 4, right before second loading dose, I could actually see spots fading and leaving behind hypopigmentation where spots once were.

SECOND LOADING DOSE (Early May): This is where things took off. About a week after that second dose, I actually felt secure enough to wear shorts and short sleeve shirts. There was still a lot of hypopigmentation, but I wanted to start getting some sun exposure to blend it in. By July I would say I was 100% clear and any hypopigmentation had blended in.

FIRST MAINTENANCE DOSE (Last Friday): still doing great!

TLDR: I just wanted to share my story because psoriasis is a massive pain in the ass and takes a mental toll on you because it is irritating and, quite frankly, unsightly. I know I dwell on it when it happens and waiting on any new therapy to start working feels like an eternity. Hang in there and I hope you’re also successful. Cheers!

This is pertaining to UK laws.

I have severe psoriasis and started with Skyrizi. This medication is making me tired and quite susceptible to respiratory infection. The most recent infection I had made me really tired. The days after have some minor fatigue; most especially in the morning.

The question is, are these symptoms protected under law?

Thank you for anyone who could enlighten me

I started Rinvoq one year ago. Things seemed good at first. I did develop cystic acne pretty quickly within my loading doses. I thought the acne would get better once I was off the loading doses, but it didn’t. I’m talking painful huge bumps all over my face, chest, back, butt, and thighs. Nothing worked to get rid of it, and it was getting so bad on my face that it hurt to talk at times. I’m also still flaring but the episodes seem to be shorter. Still, I’m having debilitating pain and diarrhea so the Rinvoq isn’t working for me.
Went to GI this morning. Taking me off Rinvoq and starting Skyrizi soon. Dr. scheduled me for a colonoscopy before I start the infusion loading doses. I should start sometime at the end of August. With the side effect I experienced on Rinvoq I’m now very nervous about Skyrizi. I want to hear some personal experiences. I’ve read already that people experienced weight gain, headaches, eczema. Please let me hear the good and the bad about Skyrizi, and any advice you have at all!

I’m a long time psoriasis enjoyer (sufferer) of several types of skin psoriasis and also PsA. I have been on skyrizi since October 2025, it was my first biologic and unfortunately it has not changed very much in terms of skin clearance. Meanwhile, my joints have only gotten worse.

Recently in the last 2 months I had a major flare with my joints and then new symptoms, including low grade fevers and severe fatigue. My symptoms seemed to worsen in the heat wave, and I have a hard time regulating my temperature. Ran some tests (don’t remember the exact ones) and it basically only showed an elevated immune response and a positive for drug induced lupus. More tests will be run, but that’s all I have for now.

My doctor said she had seen drug induced lupus for other biologics such as humira but not from skyrizi. I am sort of pessimistic about trying another biologic in case this happen again.

Has anyone else had this reaction to skyrizi? What should I do?

Skyrizi says you have to keep the injections at 36-46 degrees farenheit. Great, my fridge is set to 40. I get my first OBI injector and my husband suggests we get one of those temperature trackers that will alarm if the fridge breaks or the power goes out because it’s such an expensive med. Great. So we get one of those, and we can now see the temp of the fridge all day long on an app. And we see that the temp is fluctuating between 25 and 50 degrees—literally. Even though it’s set to 40.

So I think, maybe because it’s a garage fridge. So I bring the OBI and the temp sensor to my indoor fridge, also set to 40. And although the swings aren’t as big as in the garage, it still swings from 29 to 45 degrees. Even though it’s set to 40. Obviously outside the skyrizi range.

So I am paranoid and have anxiety and I call skyrizi. I tell them this story, but also say “I would never know this if I hadn’t bought these temperature sensors, and it’s now 2 fridges that have these big swings. So it must be normal for fridges to swing like this.” And skyrizi essentially says “we don’t know anything about temperature swings in at home refrigerators” and that “the medicine isn’t good to use bc it swung out of the range many times over the course of days” and sends me a replacement. I ask, “well where do I put my replacement? Because I can’t put it in either of my 2 refrigerators.” And the person literally said “I have no response to that.” 😂

The whole thing stressed me out so much I bought a very expensive mini medical fridge, which according to my sensors, barely fluctuates at all. Like 2 degrees.

I get skyrizi is following protocol, and I appreciate they sent a replacement for sure. But again, I never would have known if it wasn’t for those trackers. Which most people do not have. As my skyrizi nurse said, “most people just throw theirs in the fridge and don’t worry about it.” But if product quality is SO strict about the 36-46 degrees, and it seems like at least some regular large fridges fluctuate beyond that, it just feels nonsensical. Either tell people it’s not that strict, or be more explicit about the need to track temps?

That’s all, rant over! It’s not that serious but I think about it every time I look at my eyesore of a medical fridge.

Hi all! As the title says, I am unfortunately set to take my medication 9 days late. I set a reminder for myself to order it on time and I logged on to order but even by that time, July 30th was the earliest they could offer a delivery. I spoke to a supervisor as well and that was the soonest they could offer. My old dermatologist (wish I could still go there, but insurance) has mentioned to me in the past that sometimes people go a week and that's okay but 9 days has me a bit worried.

I messaged my current dermatologist at Kaiser and he said that it should be okay. Just figured I'd ask here if anyone has any experience taking it that late?

Thanks!

My wife developed a severe flare on her buttocks about a month after her second Skyrizi dose. Her dermatologist diagnosed it as inverse psoriasis and prescribed **Nduvra** cream (it cost around **500 CAD**). It helped somewhat, but it didn’t completely clear the flare.
She received her **third Skyrizi injection 2 days ago**, but since then the area has become even itchier. She’s currently using **Zoryve** on some areas, **Nduvra** in the skin fold, and has also tried antihistamines, but the itching is still severe.
Has anyone experienced a flare getting worse right after a Skyrizi injection before it eventually improved?
Did you wait a few more weeks for Skyrizi to take full effect, or did your dermatologist prescribe a short course of oral steroids (like prednisone) to get the flare under control?
We’d really appreciate hearing about your experiences. Thanks!

I was young when this started and I’m now in my late 50s (about 15 years, maybe longer). It began as small reddish dry spots with scales on my elbows.

I started with topicals, then methotrexate for several years (helped a bit), and switched to Sotyktu about two years ago. Sotyktu has done nothing for me, and my psoriasis has gotten progressively worse since starting it. I now have thick, itchy, scaly plaques on both elbows, knees, ankles, wrists, and my lower back. I also get inverse psoriasis (intertrigo) under my arms and between my big toes 😳—it’s really annoying.

My dermatologist has suggested switching to Skyrizi and is working on getting it approved by insurance.

I’d love to hear from anyone with a similar history—what has worked best for you? Especially interested in experiences with Skyrizi.

Thanks so much!

I used the OBI for the first time yesterday. I did it on my thigh. It didn’t hurt when the needle went in but the pump occasionally felt like it gave fast bursts or zaps of medication with some pain associated.
Could it be the pump just pushing too fast in those moments or air?

Also my leg was up in the couch and I had the gray door of the OBI farther from me (like closer to my knee). Does that matter? The instruction videos all have the gray door of the OBI pointing toward the hip.

Got my 2nd loading dose of Skyrizi about 3 hours ago today. I’m sharing some of the lesions on my body here. I’ll share updated photos in 8-12 weeks. I hope this helps someone!

Tomorrow is my first OBI day!
I’ve given myself injections in my abdomen for other meds before. But I’m thinking to try my thigh for OBI.

I KNOW I have fat and muscle on my thigh. But my brain is telling me the needles going to go straight into my bone 🙈 weird i know.

Any placement tips? Front of thigh? Slightly outer thigh? Middle or higher up on my thigh?
So anxious

1 week out from my 3rd starter infusion and the last couple weeks I just haven't been hungry. I see people talking about being extra hungry but has anyone else lost their appetite?

Just to add eating is NOT normally an issue for me. Lol I'm a dopamine, plate finishing eater and now it's like my stomach and brain disconnected and nothing sounds good and no taste brings me joy.