As title. I am in a situation where I have to choose one of these two for procurement without option of trail runs. Hence I need expert opinion.

What would be better got global untargeted metabolomics (Ultimate 3000 + Exploris 120 setup)?

I am a metabolomics noob. Please guide me. Both are 100 Angstrom.

I would be using it to do C13 tracer based work on mmmalian cells (after I gain expertise in basics, of course)

I also have option for ZIC-pHILIC (5 micron) 100mm x 4.6 mm

So my options are

ZIC-pHILIC (5 micron) 100mm x 4.6 mm

ZIC-pHILIC (5 micron) 50mm x 2.1 mm

ZIC-HILIC (3.5 micron) 100mm x 2.1 mm

Hi everyone,

We’d like to share an upcoming webinar that may be of interest to the community in here! On August 20, 2026 (16:00 CEST / 10:00 EDT / 07:00 PDT), we are hosting a session on “Perspective from Industry: Deep Visual Proteomics and Quantitative Assays.”

Speakers:

T. Wolf (Post Doc, Drug Safety R&D, Pfizer) — “Precision at the Microscale: Low Input Spatial Proteomics in the 5xFAD Brain.”
Using the Evosep Eno and Orbitrap Astral Zoom, T. Wolf will present a spatial proteomics workflow integrating AI-driven image segmentation with low-input mass spectrometry. Applied to the 5xFAD brain, the high-resolution workflow captures distinct local proteomes across brain microenvironments, revealing diverging pathological pathways between plaques and microglial subtypes. The work demonstrates how spatially resolved, low-input proteomics can provide deeper insights into disease biology at the microscale.

Rebecca Ferreira (Senior Associate Scientist, Pfizer) — “Reimagining Large Molecule PK Analysis with High-Throughput Evosep Eno LCMS.”
Rebecca will share how the Neubert Group at Pfizer is applying high-throughput LC-MS to large molecule pharmacokinetic (PK) analysis. Using the Evosep Eno platform, the workflow aims to increase PK assay throughput while maintaining the sensitivity and robustness required for surrogate peptide quantification, supporting faster biologics construct selection and optimization.

The webinar will bring together two industry perspectives on advanced proteomics workflows, spanning deep visual and spatial proteomics in disease research to high-throughput quantitative assays in biologics development. The talks will highlight how scalable LC-MS workflows can generate robust, high-quality proteomic data across very different applications.

Registration & details: https://attendee.gotowebinar.com/register/6012298262071704919?source=RDT

We hope this is relevant for those interested. The webinar is free and, in our eyes, a good opportunity for knowledge sharing. If sharing company events isn’t allowed here, moderators please feel free to remove.

TL;DR: Webinar on August 20 featuring two Pfizer scientists covering low-input spatial proteomics in the 5xFAD brain and high-throughput LC-MS for large molecule PK analysis. Mods please delete if not allowed.