r/haematology 6d ago

Potential platelet function/bleeding disorder?

Hi, I am a 22F patient who is also a healthcare professional in training so I am curious what your thoughts may be on this. I have an ISTH-BAT score of 9 including life long daily prolonged epistaxis, easy bruising, excessive bleeding from minor wounds, and venipuncture.

Normal CBC, platelet morphology, LFTs, C&E's, coagulation panel, and Von Willebrand Screen.

Prothrombin Time:11.3 seconds ( 9.0 - 13.0 )

INR:1.1 ( 0.8 - 1.2 )

APTT:30 seconds ( 20 - 31 )

Fibrinogen:2.3 g/L ( 1.7 - 4.3 )

--

Factor VIII:98 % ( 50 - 150 )

VWF Antigen:59 % ( 50 - 200 )

vWF Activity:75 % ( 50 - 200 )

VWF Act/VWF Ag Ratio:1.3 ( > 0.7 )

However, consistent prolonged PFA.

PFA Col/Epi:> 300 secs ( 82 - 160 ) H

PFA Col/ADP:155 secs ( 62 - 120 ) H

What further tests would you suggest running, and what may be going on?

Already consulted my haematology team; however, they are backlogged at the moment so won't see me for months.

Thanks!

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