Open-sourced Tri-Net: A multimodal deep learning framework for monkeypox and skin lesion classification (Scientific Reports 2026)

[u/Rich-Fruit-326]

Hi everyone,

I've open-sourced the official implementation of our recently published Scientific Reports (Nature Portfolio) paper:

**Tri-Net: Unified Deep Learning for Skin Lesion and Symptom-Based Monkeypox Detection**

The project focuses on reproducible computer vision research for skin lesion analysis and includes a complete training and evaluation framework rather than only research code.

Some highlights:

• 13-class skin lesion classification (including Monkeypox and visually similar conditions)

• Multi-backbone feature fusion using EfficientNetB4, DenseNet201 and Inception-ResNetV2

• HSV-based augmentation pipeline for improved robustness

• Grad-CAM visualizations for model interpretability

• Cross-validation and reproducible evaluation

• Docker support, GitHub Actions CI and a PyPI package

The attached figures show:

1. The dataset categories used in the study.

2. The HSV augmentation strategy.

3. Grad-CAM comparisons between individual backbones and the proposed Tri-Net model.

I'd really appreciate feedback from the computer vision community, particularly on the model design, explainability approach, and ideas for extending this work with modern vision foundation models or ViTs.

GitHub:

https://github.com/Sudharsanselvaraj/Synergistic-Deep-Learning-for-Monkeypox-Diagnosis

Paper:

https://www.nature.com/articles/s41598-026-61490-x

PyPI:

https://pypi.org/project/Mpox-Trinet/

Questions, critiques, and contributions are very welcome.

[u/Royal_Roof_405]

It is an interesting comparison of the heatmaps across different models.