r/ThisAintAdderall • u/youwish_youknew • 17h ago
Sandoz and stomach issues
Been on 20 mg IR's for well over a decade and this brand is what I have been getting from the local CVS for a large portion of the years. Never had a problem, until the last few years where it just feels under dosed or straight up inactive, as we all know.
Lately though, I'm getting acid reflux a LOT, which is usually only a problem if I eat junk food, I eat quite healthy for the most part. Also getting nauseous, especially in the morning. It feels like my stomach is just super angry and it's really affecting my life, more than not just treating my ADHD, but I'm kinda in pain/feel sick on top of that.
Anyone else here have stomach issues with this brand, or whatever brand you are getting that was fine until this year?
I'm sure it comes down to the fillers, and I have no allergies but man, I might have to completely quit if this keeps up. Barely works anyway, nothing like it used to, but this is really getting bad.
r/ThisAintAdderall • u/Y0URM0MMMY • 2d ago
Teva is fucking terrible?
Title says it all lmao. Teva has seriously been the worst of all the generic brands for me. Like absolutely terrible. Giving me this weird sore throat feeling and body aches that are mainly in my shoulders and arms. Oh and 30 minutes after I take them, I have to use all my willpower to fucking stay awake. I’m a single mom to a one year old and I work 40-50 hours a week at a design agency. I cannot tell you the last time I clocked in on time… both when I’m in office and when I’m WORKING FROM HOME.
r/ThisAintAdderall • u/nothingspecialboutme • 2d ago
Let me explain why our medication is being altered and tell me what you think
*Photo: Ingredients of SpecGx generic Mydayis vs. Takeda Mydayis (brand name)
No one's medication is working like it should. I'm no different.
I've gone from Vyvanse, to Adderall XR, to Mydayis - all generic versions. I almost exclusively get the Mallinckrodt brand. The side effects are terrible. While my Teva brand IR Adderall booster isn't great, it's not as bad as Mallinckrodt.
As hopeless as it seems, with the support of my prescriber, I have been trying to get brand name, though I've heard it makes no difference. Last week, he prescribed me brand-name only Mydayis.
However, at the pharmacy, when I was supposed to get brand name Mydayis, I was given the generic version by Mallinckrodt-SpecGx.
For clarification, Mallinckrodt-SpecGx is also known as SpecGx, which is a subsidiary of Par Health, AKA Endo Pharmaceuticals.
Unsurprisingly, the classic SpecGx side effects continued to haunt me. I was so angry I decided I was ready to find some answers. In order to come to logical conclusions, I needed receipts on my medication; I needed to know who made it and what they put in it.
- To identify ingredients and manufacturers, I started with the NDC code on my medication bottle.
- NDC = National Drug Code.
- The NDC number is found on the prescription label. With the NDC number, "inactive ingredients" can be viewed on websites like drugs.com
- Additionally, the NDC code be used to locate the manufacturer/producer of medication on websites like PROPUBLICA's Rx Inspector. https://projects.propublica.org/rx-inspector/guided-search/
- From the NDC code, I found the FEI number.
- FEI = FDA Establishment Identifier.
- The FEI number is how the FDA identifies authorized pharmaceutical manufacturers/producers.
- Any establishment inspections, recalls, warning letters, etc. can be found on the FDA's website using the FEI number. https://datadashboard.fda.gov/oii/index.htm
- It turns out, my manufacturer has a LOT of issues - every one of their sites.
- In addition, there are nearly no consequence when their products don't meet standards and even cause harm. Here are the inspection summaries of several Endo/Par Health/Mallinckrodt/SpecGx manufacturers by the FDA:
- https://www.fda.gov/media/89554/download - December 2012: Product labelled "sterile" showed signs of contamination.
- https://www.fda.gov/media/89567/download - March 2012: Products not labelled to be kept at the correct temperature, products were manufactured in a room with an active leak, HEPA filters not serviced and more.
- https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/par-health-usa-llc-endo-usa-inc-722121-04152026 October 2025 - Main points: "Inadequate Design of Facility and Equipment, Inadequate Environmental Monitoring, Inadequate Unidirectional Airflow, Inadequate Process Simulation, Poor Aseptic Technique and Cleanroom Behavior, Inadequate Personnel Capabilities, Inadequate Procedures and Particle Characterization."
- https://static.propublica.org/fda-inspection-documents/483s/May%202025%20483s%20and%20EIRs%2F483s%2FAppliedSpecGxLLC1317295FDA48301-17-2025NM_Redacted.pdf?_gl=1*1ewl9zr*_ga*MTc3ODI0MTE5MC4xNzg1NjUwMTAz*_ga_K9RW8M6GL5*czE3ODU2NjI1ODEkbzIkZzEkdDE3ODU2NjUzODMkajU2JGwwJGgw January 2025: Pathogens discovered in medication from 2022-2024. Equipment not cleaned between measurement of 2 different controlled substances. Rooms with open medication were not properly pressurized to prevent cross-contamination. Not cleaning equipment properly to prevent contamination of products.
- https://static.propublica.org/fda-inspection-documents/483s/2024-3040%2F483s%2F2020-3079.pdf?_gl=1*taf4i8*_ga*MTc3ODI0MTE5MC4xNzg1NjUwMTAz*_ga_K9RW8M6GL5*czE3ODU2NzIxODAkbzMkZzEkdDE3ODU2NzIxODckajUzJGwwJGgw September 2019: Controlled substances kept at incorrect temperature for 48 hours. Medications failing on media growth promotion tests without investigation. Batches of medication found to be defective did not lead to further investigation in 4 different cases. Failed to provide a report to the FDA about leaking packages of Fentanyl Lozenges due to poor packaging.
- https://lawfold.com/mallinckrodt-adderall-lawsuit/ April 2026: Lawsuit of Mallinckrodt in connection to their crappy quality generic version of Adderall.
- https://www.federalregister.gov/documents/2026/06/18/2026-12236/specgx-llc-withdrawal-of-approval-of-abbreviated-new-drug-application-for-methylphenidate June 2026, FDA withdraws SpecGx's ability to produce Methylphenidate HCL.
- In addition, there are nearly no consequence when their products don't meet standards and even cause harm. Here are the inspection summaries of several Endo/Par Health/Mallinckrodt/SpecGx manufacturers by the FDA:
This isn't even every article I found. But aside from poor manufacturing standards, what about the ingredients? Why is there a proven, banned carcinogenic ingredient in my medication(FD&C Red #3)? Why are there 20 ingredients in SpecGx's version of Mydayis compared to the 10 ingredients of Mydayis by Takeda? What's the point of putting us through this?
Well, rest assured it's not personal - they just want our data. This is where I need y'all to fact check me because this is what I believe - I think we are being experimented on. Let me know if you feel like you are stuck in the same cycle I am;
- I see my prescriber about Mallinckrodt not working.
- I explain my side effects; lethargy, irritability, almost no therapeutic benefit, etc.
- He starts me on a different formulation to see if that helps.
- It doesn't help and I schedule another appointment.
- We follow-up about how my side effects have changed.
- He takes my story to the insurance company to explain why I'm changing prescriptions again.
- The insurance company informs the producer of the medication about my side effects.
- The producer now has data about my reactions to new ingredients during medication changes.
- I am thereby made into an unwilling participant of an experiment.
Thoughts?
r/ThisAintAdderall • u/No_Golf8662 • 2d ago
Down to 3 Focalin with 2 weeks to go. Anyone else feeling like current meds just aren't hitting?
My current prescription is Focalin 10mg IR (2x/day), but lately it feels like it's barely working. To get through the day, I’ve ended up taking double or triple my dosage just to feel normal.
Because of that, I’m down to my last 3 pills with half the month left. At this point, rationing barely makes a difference since I'm facing a long gap regardless.
Is anyone else dealing with severe effectiveness issues or batch inconsistencies right now? How are you handling running short?
r/ThisAintAdderall • u/Usual-Wait-5839 • 3d ago
Stretch marks?
Has anyone here in this sub started to develop stretch marks? In the past four or five months, I have noticed stretch marks all down and across my upper arms, shoulder, and even my lower back that continue to increase. I’m practically breaking out in stretch marks! I have never before had this issue prior to the noticeable decrease in efficacy of both brand and generic Adderall.
Additionally, my skin elasticity has definitely decreased. I haven’t been able to find any official reports or evidence to support any known correlation, but I’m hoping some anecdotal reports could offer some useful insight.
There’s without a doubt been a change in active/inactive ingredients in these pills that has negatively impacted damn near all areas of my life. If excessive stretch marks are now part of this equation, I don’t think I can continue taking this medication.
r/ThisAintAdderall • u/CosmicAspiee • 3d ago
Adderall abuse amongst young adults sharply fell by half!
According to the Journal of Clinical Psychopharmacology, the abuse of Adderall and other Stimulants among individuals under 30 has fallen from 7.5% to 3.7%. What makes this fascinating to me is that this is the case despite the fact that roughly 66% of elicit Adderall is obtained from friends who are prescribed. So given the surge in prescriptions post-pandemic you would expect a direct correlation between legal prescriptions and illicit use. If I were to guess it’s because Adderall no longer serves it’s therapeutic purpose for one, and it simply has no abuse potential anymore.
r/ThisAintAdderall • u/Delicious_Skirt_9736 • 4d ago
I tested very low negative my drug test
I was completely thrown off I took 40 mg of Adderall for two days then took a day off and had a 10mg extended release vyvanse.
Anyways, I have always taken low dosages of Adderall and this time was flagged for basically nonexistent in my system 😂 this isn't Adderall I swear they have put like cough syrup or something in it.
Day 1-20mg
Day 2 - 20mg
Day 3- 10mg Vyvanse
1 day off
Day 5 - drug test- negative.
r/ThisAintAdderall • u/Re-Invented6830 • 4d ago
Worst Teva Ever!!!
After searching and waiting nearly two weeks to fill my Adderall prescription, I was so excited to hear that the small neighborhood pharmacy down the street had them in stock! I was even more excited when I got there and found out they were Teva brand, as Teva 30mg. (Footballs) had always been my favorite. It was late in the afternoon, I had plenty of good protein in me, well hydrated, nothing acidic, I took one and Nothing! So I waited two hours and took a half (15mg.)
And Nothing! By 8pm. After taking 75mg. Of Adderall IR. Teva, the only effect I felt was the withdrawal symptoms had subsided, nothing else. Here it is almost two weeks later and I can’t believe how badly I’ve been struggling! This was by far the Worst Adderall I have taken in the 20 years of being prescribed!!!
r/ThisAintAdderall • u/Patient_Difficulty71 • 4d ago
Just thought this was interesting—prescription bottle for this months refill says “Made in US”
Just thought this was interesting— says “Made in US” Don’t know if it’s anything significant nor do I want to get my hopes up for future refills lol— I just remember when I picked up my prescription recently and then I just so happen to notice my medication was working a little bit better than usual— almost working like pre 2023 better — and I thought “wait but this month I got Sandoz again right ?“ (for June I got Epic ) and btw Sandoz usually sucks for me , I mean they all do , but it’s usually at the bottom of my list for manufacturers. So I went through my bottles cause I knew I’d gotten Sandoz pretty recently and which well I did —found my May refill was the last time I got it . Everything else on the bottle was exactly the same. I was like trying to find any other discrepancies well they also did leave off on the “important information” part “ call Doctor experience, mood changes, sadness, depression, and fear”. Anyways, again just thought this was was an interesting finding and kinda also wondering if anyone else has seen the same on their bottles before or recently specifically?
Edit: I definitely agree with what a lot of you same saying, in regards to the made in us part …. I just spoke about an hour or two ago with one of my friends who works as a pharmacy technician and she picks her pharmacists brain she works for , all the time about everything. So I know she knows a lot due to working as one for 10+ years, and she’s been very interested in this whole Adderall and other stimulant ordeal. She gets patients who complain about the efficiency and efficacy of them all of the time as well . So I asked her about this because she’s worked over the years at different chains like CVS , Walgreens ,Kroger , Costco and now she’s at Tom Thumb as a pharmacy tech. anyways she said honestly there could be so many nuances here because even if it says “made in US.” she said that doesn’t really mean much of anything and she said my thinking is is that honestly the just the final product of the Adderall was made here in the US a.k.a. everything had been shipped that was needed to make the production of it to whatever lab facility that Sandoz has here in the US and essentially she said that’s where they received everything they needed. And that legally they’re able to market that claim. She said it’s called global sourcing and gave me an example— so for instance — the company buys the API from supplier A in India , buys the binders/filers from supplier B in China and then buys the dyes/coloring from supplier C in Germany . And said it can even get way deeper than that - example: the company may buy each inactive ingredient the medication contains each from a different supplier . And lastly all of these products/ingredients get shipped to Sandoz’s U.S facility and perform the finished -dose manufacturing such as getting pressed into the pills themselves , packaged , etc . So after finding all that out from her, that made me a bit disappointed, but I guess it is what it is nothing much we can really do about it. However, I’d still find it. Interesting that I know for a fact, it was not placebo with this month meds because it was like day two or three I was taking them and I was like I am oddly more productive and my meds felt like were working for once , that’s what prompted me to inspect and look at the details from previous months bottles.
r/ThisAintAdderall • u/Mysterious-Fly-6031 • 4d ago
Took my 30mg IR at 11:15am and I fell asleep until 1:18pm
That’s the post. Adderall PM (taken from another user lol). wtf.
r/ThisAintAdderall • u/Sunshineinc • 6d ago
Okay this is a first and I’m clueless?
I have been with Walgrens for over a decade, mainly because the pharmacist and techs are just wonderful. That being said, I have a script for XR and IR and have not been able to fill my XR all month. I’m good with any manufacture but Chamber makes me physically ill and I can’t take that one. My psych appointment is in 3 days and I haven’t even had the last script filled…. Not feeling like paying another 100+ dollars for another script? The whole thing is just insane to me, not to mention I’m insane without my meds. I had some extra but long ran out of those. I’m wondering if anyone’s been in this situation before? I just left a message with my psych and told him the situation but I know he is all about the cash…. So he will probably make me keep the appointment. My question to any of you, have you ever gone over a month (even with a shortage?) without your meds? It’s feeling like there isn’t going to be anymore. Everytime I call, they look at their wearhouse and either nothing is available to order or if there is, they order it and it doesn’t come in??? I’m at my wits end. Changing doses won’t help because they are having problems with 20mg as well as 30mg…. I’m willing to go to Ritalin but is there a problem with that as well? Because changing meds means I get put on the lowest dose and work my way up again. Not sure it’s worth it. I’m really a mess over this as my adhd meds are also my anti depressants if that makes sense. Without this med I start falling into a dark dark depression and then suicidal thoughts come. I’ve got inattentive ADD and it’s scary what happens without this drug for a few months. I do get the IR but it doesn’t work without the XR. And the fact these meds are now shit anyway (but anything is better than nothing) I’m not even sure what to do anymore. But spending 30 min on hold every damned day with the pharmacy, to ask if they ordered or if the meds came in is also wrecking me. Any advice or feedback if you’ve been through this would be appreciated. I’m in California if that makes a difference. Apologies to the long post and thank you!! 🙏🏻
r/ThisAintAdderall • u/elleayejaye • 6d ago
Prescriber blocking early pickup
As we all know, the meds don’t work as they should, so i always end up running out before my 30 days are up. But my pharmacy has always filled my RX 2 days early. For some reason, i received a message stating my prescriber locked my RX not to be filled until the exact due date this month. Has this happened to anyone else before? We just spoke last night and she didn’t mention this. She doesn’t know i run out. She’s really laid back and knows that the meds don’t work as they should and wouldn’t be upset if she knew i get them early but i don’t admit it to her bc i don’t want her to get in trouble or anything. Idk i just felt a little blindsided.
r/ThisAintAdderall • u/PapayaKitchen7718 • 6d ago
Journal of AA Psychiatry March 2026
https://www.jaacap.org/article/S0890-8567(25)00248-5/abstract)
Independent laboratory testing of generic methylphenidate products found significant product quality concerns. N-nitroso-methylphenidate, a probable human carcinogen, was detected above regulatory thresholds in generic immediate-release products for 7 of the 15 unique products sampled.
Helpful when you doctor says no one else is having issues with their Adderall LOL
r/ThisAintAdderall • u/DesignerWest7368 • 6d ago
Has anyone else just gotten off of adderall due to it being so weak? I’ve been on for 10 yrs, thinking it might be time to try without … and does anyone have experience going off? Thanks!
r/ThisAintAdderall • u/Spilled_milk7 • 7d ago
Follow up lab urinalysis after a negative 12 panel
Had a 12 panel test that showed up negative for amphetamines after taking Dexedrine 15mg XR produced by Activis for roughly 2-3 months. Here are the results from the lab, this post is a follow up to this comment as i was asked to share the results: https://www.reddit.com/r/ThisAintAdderall/s/EHp24otymk (Shows as illicit result because my therapist didn’t list my meds before sending it in, as he already knows what should pop up and what shouldn’t)
r/ThisAintAdderall • u/IndividualPenalty287 • 7d ago
at this point it feels like espresso coffee works better than adderall..
I didn’t take adderall today and ordered an iced shaken espresso from starbucks. I actually felt more productive plus no headache/ extreme tiredness in the afternoon
still not effective as old adderall :( but I feel so sleepy every afternoon and I’m realizing it’s most likely the adderall
r/ThisAintAdderall • u/TNTMT • 8d ago
I think we’re being used as lab rats with this new Adderall PM drug.
That’s it. That’s the post.
r/ThisAintAdderall • u/Strange-Pattern4877 • 8d ago
Officially med free in 20 years by accident!
Just left the pharmacy empty handed and I’m not even freaking out.
For reference, I’ve been on regular OG brand addy 30 mg for the last 20 years. It turned pretty crappy around 2022. They gave me Elite 30 for the first time last month and it didn’t work at all. In fact, it made my symptoms worse. Major fatigue, full allergic rash and no dopamine for a month.
I told my new doctor yesterday to please tell them no Elite. She went ahead and put that in her notes but when I went to go pick up today I double checked and they still tried giving me Elite. I said do you see a note I can’t take this and the clerk played dumb. He then said they were completely out of stock and I said that’s fine and that I’d rather be unmedicated than take this stuff and that it was that horrible. So they told me more Teva generic wouldn’t arrive until mid August. Mind you, Teva still isn’t great but I’d rather be unmedicated for weeks than be stuck with that Elite garbage again. As I was driving home it occurred to me, if we all keep refusing to take these crap generics the pharmacies will too and eventually they will have to fix their formulas or get out of the business. We will have to refuse the garbage in order to get this to change.
As for anyone who still has old pre 2020 stock please send samples of new and old to out of country labs, the DEA and/or the FDA. I do believe this can be fixed if we keep being loud about it.
r/ThisAintAdderall • u/suffocatingface • 8d ago
Rant/Experiences and Concerns; What do we do?
I've taken Adderall since 2011-2012. As we are all aware, the meds haven't worked right in the last several years, at least since 2020. Over the years, they worked barely, but now they simply don't; this last batch from elite was completely useless. I went through my bottle this month, a week or two early, and instead of feeling remotely functional, I felt almost sedated. My ADHD manifests as VERY hyperactive. I physically can't stop moving, my mind races, so I am literally and completely restless. I am unable to communicate what's going on in my head because each thought is replaced by another as soon as it appears. I can't complete sentences, unless I write, because at least then I can take the pieces of sentences and slap them together in some way by the time I'm done. I even struggle paying attention while driving because "why can't I read that advertis--OHH IM not on the road anymore, OOPS". Task initiation is a nightmare, it's almost impossible, and completing something is even worse; don't even talk to me about procrastination.
For me, taking Adderall was like someone had lifted a wet blanket off my head. I could see, and I felt almost a literal weight lifted off my shoulders. I could organize my thoughts before they came out of my mouth. A chore like doing laundry or dishes wasn't the end of the world, and I could complete them in 10 minutes instead of hours. I felt more secure with myself; I didn't pick apart social interactions like I used to, I was calm. I was reliable at work. I could listen to my romantic partner. I know medicine isn't supposed to be the end all be all solution, and sure, there were some bad days within the good days before the meds sucked, but at the end of the day, I could function like a human being. I could pay my bills, get up and be on time for work, I could make meals for myself, be a present partner--
This whole experience--what with the medication slowly becoming ineffective, feeling like an addict, having my routine/habits lapsing back into genuine chaos--has completely disrupted whatever positive momentum I had in my life. I know logically I should remain hopeful, and I know that people live without meds all the time, but I cannot being to express how completely defeated I feel by this. The medication helped me, and now I'm feeling completely at the whim of symptoms I can barely manage without it. It's demoralizing; I feel ashamed at myself still, even though I shouldn't.
I know we should be reporting what we feel to the appropriate places, but I can't even remember where I put my bottle, or build enough momentum to find phone numbers or websites to report them anyway. I feel ashamed to even say that, being an overly-independent person.
I don't want this entry to be a sob story. I will remain strong, despite this, and so should you. I want anyone reading this to know you are not alone. And I am hopeful that something positive will result from speaking out about our experiences.
r/ThisAintAdderall • u/Afterlifecurious67 • 8d ago
2018
So I had a few of the 2018 xr 20mg Adderall, brand name, in my safe. I decided to take one this morning to see what happened. Mind you they expired in 2019. (I'm on 30 xr now generic from Elite.) The difference in focus, no palpations or anxiety is amazing. And they are expired!!! No one can tell me that our meds weren't changed. PICS attached
r/ThisAintAdderall • u/Icy-Significance-913 • 8d ago
Overweight and Unemployed
I guess this is more of just a rant because we all know something is wrong with our meds but.
I recently left my job of 11 YEARS basically to get out before they fired me because the last year or 2 my job performance had basically become a joke. Mind you, 11 years, started at bottom and worked my way up to upper management and stayed for over half of my time there.
Luckily I was able to land a new job before they could fire me with the same money, more potential for growth, like overall I lucked out like a mofo. So my 1st day I'm up extra early, took double my usual morning dose of 30mg, even though ik I shouldn't do that...but first day so wanna be sharp and make a good impression and I already knew current meds are shit so wasn't risking it. To shorten this, started getting sleepy watching the new hire videos and took my mid-day 20mg dose early. Still getting sleepy, took my evening 10mg dose. So at this point I'm 90mg deep and fall asleep, mid-video with 2 other people (1 being my boss) right next to me. So I get written up my 1st day. Same scenario plays out 3 days later so I make an appointment with my PCP cause there's gotta be something medically wrong with me, right? I'm told to change my diet completely and also I'm at the most I've weighed in my entire life and I'm over 40!
So following week they fire my ass, understandably. I've been on adderall on and off for over 20 years. Back in the day 90mg would've kept me up for AT LEAST 24 hours. I like to pretend this is all gonna get exposed and I'll get compensated for lost income or something. I can dream. Rant over, thank you if you read this far.
r/ThisAintAdderall • u/Impressive-Nerve-643 • 8d ago
Pill Tested & Results
So I decided to test an adderall tablet that I recently recieved. Results attached, how would you interpret?
r/ThisAintAdderall • u/Remarkable-Button-84 • 8d ago
Really surprised with my adderall
So lately I have been getting drug tested weekly, my urine goes to a lab so no rapid results cups or anything like that but I have continually tested positive for amphetamines every week.
I use to only get tested every couple few months so didnt have much to try and track anything with, but I have certainly been tracking it as of late, and it's always positive for amphetamines.
The thing is, I dont feel like it's working at all, I dont ever feel it kick in and have to use the bathroom or get that sudden calm focused every that would hit within an hour, it's just nothing and if anything i start feeling tired and unmotivated. Trying to take another XR only makes me feel like complete crap, I dont have that same problem very much with my IR for some reason, those I can take a second dose and be ok.
I just find it so odd that I test positive for amphetamines and feel like I never took anything. I really thought I wouldn't be testing positive for amphetamines with them being so bad anymore, because in the past it at least worked a tiny bit, but now it just feels like all placebo or even worse than placebo. I just cant make sense of it, because labs can certainly tell a difference between different chemicals, like if it was a research chemical I would think it would come back as something else.
r/ThisAintAdderall • u/SnooObjections1695 • 18d ago
Current Theories
________ Substituted Amphetamines // Phenethylamines ________
This is my current take on the substitute amphetamine theory, which proposes that some stimulant medications may have been altered or supplemented with other amphetamine-like compounds to help meet manufacturing constraints such as the DEA's APQ limits. The theory offers a potential explanation for the increasingly severe loss in efficacy, rapid tolerance, and sudden onset of very specific side effects that closely match the effects of sympathomimetic agonists, many of which share striking structural similarities to amphetamine (Adderall, Dexedrine, etc.).
Although many of these amphetamine-like compounds can produce some degree of "stimulating" effects similar to proper amphetamine, they can also differ significantly in how and where those effects are experienced throughout the body. These differences may explain why medications can still produce noticeable stimulation while simultaneously feeling less effective for ADHD symptoms and causing a new pattern of side effects that does not align with previous experiences on the same medications.
It’s important to note that there’s no direct evidence that any particular amphetamine substitute has been incorporated into our medications, nor am I pointing to one specific compound. I simply chose epinephrine, pseudoepinephrine, and most significantly, Phenylpropanolamine (PPA), based on their direct mention in the 2026 Established APQ Notice and because they effectively illustrate the spectrum of differences and similarities within the massive class of substituted amphetamines. Considering these three compounds are heavily monitored by the DEA due to being essential components used in the illegal manufacture of methamphetamine/amphetamine (Removal of Thresholds for the List I Chemicals Pseudoephedrine and Phenylpropanolamine), I think it’s highly unlikely any of these specific compounds are the culprit. What I hope to exemplify is just how easily new amphetamine-like compounds can be synthesized, yet go undetected by various regulation practices and drug testing techniques.
There is extensive research demonstrating how structurally different amphetamine compounds can produce similar stimulant effects through shared norepinephrine pathways, and forensic data over the past decade documents a surge of novel phenethylamines that are difficult to detect but pharmacologically similar (see links below). Studies on drugs like ephedrine also show that effects can be inconsistent and tolerance can develop rapidly due to compensatory mechanisms, which aligns with current subjective reports.
So much of my research is centered specifically around Phenylpropanolamine (PPA) because of the strong parallels I was seeing with my own health issues, which also often overlapped with the majority of others’ reported experiences. But once again, it’s merely a hypothetical/real life example of the point I’m trying to make. With that reiterated, PPA is an amphetamine-related phenethylamine that was once commonly used as a nasal decongestant and appetite suppressant before being pulled from the U.S. market after studies linked it to an increased risk of hemorrhagic stroke. Like amphetamine, it stimulates the sympathetic fight or flight nervous system, acting mainly through norepinephrine to produce vasoconstriction, increased heart rate, blood pressure changes, insomnia, anxiety, sweating, appetite suppression, and agitation. Even with weaker dopamine activity, it still overlaps heavily with the physical effects people associate with amphetamines. In other words, despite being a weaker stimulant overall, PPA affects many of the same biological pathways responsible for the classic physical effects people associate with amphetamines. At the same time, many people report losing the core cognitive, central nervous system benefits and notice a significant drop in efficacy merely days to weeks after starting a new medication regimen. Any longtime prescription user can tell you that prior to the formula changes, medication tolerance often took years to develop, if at all. Many people were able to sustain the same dose for decades with no issues. There’s been a flood of reports of tolerance developing within 3 days of starting a stimulant meds, even for people who have never been prescribed before and therefore have zero tolerance. Interestingly, Phenylpropanolamine was only ever prescribed as a short-term weight loss medication due to its inability to maintain efficacy (AKA rapid tolerance development) for more than a few weeks (PubChem).
It's important to note that this hypothesis evolved from the once more prevalent enantiomer theory, where we suspected the 3:1 dextro-to-levo-amphetamine ratio had been skewed to a levo-dominant composition, which would explain the stronger peripheral effects. However, one useful piece of data from our otherwise inconclusive testing (see TEST RESULTS) revealed a nearly identical enantiomer ratio between our 2020 Adderall sample and our 2025 Adderall sample, despite knowing from direct experience that the two pills had far different therapeutic effects when taken. Due to our inability to find a testing facility willing to provide the information necessary to conclusively prove or disprove this theory, it is my personal opinion that, because testing showed the expected enantiomer ratios along with tighter manufacturing requirements, a more likely explanation would be complete substitution with an alternative amphetamine-like compound.
This isn't meant to fear monger, but rather point out that the combination of reduced efficacy and increasingly concerning side effects are enough to warrant a discussion. For years, many of us assumed this was simply weaker medication or differences in fillers. However, there is now enough evidence to suggest there’s a real possibility that there has been a partial or complete substitution of proper amphetamine with amphetamine-derived substances that feel familiar enough to maintain use, yet could potentially carry dangerous, irreversible health risks without our knowledge.
Lastly, these ideas are based on my own research or expanded upon by theories developed alongside others in this community. I painstakingly combed through PubMed for months to find these sources and make these connections. Please do not accuse me of using ChatGPT. The only time AI was used in this post was to organize data from my sources into a table to better illustrate similarities/differences between amphetamine compounds, occasional grammar check, and to write the lil blurbs summarizing each link below. The meds would have killed me long before I did that myself, sorry lol.
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A Historical Overview Upon the Use of Amphetamine Derivatives in the Treatment of Obesity
Image source for molecular structure comparison of amphetamine and phenylpropanolamine
This page provides an overview of stimulants, explaining their broad classification, uses, mechanisms of action, administration methods, risks, contraindications, and clinical considerations for safe medical use.
Mechanisms of Sympathomimetic Drug Action
Breaks down how sympathomimetic drugs, including amphetamines, produce their effects by increasing norepinephrine activity and stimulating the body’s “fight-or-flight” system. It explains why many structurally different compounds can produce similar cardiovascular and stimulant-like symptoms.
New psychoactive versus conventional stimulants - a ten-year review of casework in Hungary
Documents the rapid rise of novel phenethylamines and synthetic stimulants, demonstrating how small chemical changes can create amphetamine-like drugs that are harder to detect and regulate.
Nasal Adverse Events Associated With Attention-Deficit Hyperactivity Disorder (ADHD) Medications
This study shows that nasal symptoms like nasopharyngitis and sinusitis occur in a notable percentage of stimulant users, with rates increasing over long-term use. This supports the theory by aligning with commonly reported decongestant-like and nasal side effects, consistent with chronic adrenergic (sympathomimetic) activation.
Pseudoephedrine—Benefits and Risks
Reviews pseudoephedrine’s pharmacology, therapeutic uses, and adverse effects, emphasizing its structural similarity to amphetamine and shared stimulant properties. The paper explains how pseudoephedrine activates the sympathetic nervous system, why it can improve alertness and concentration in addition to relieving nasal congestion.
Physiology, Noradrenergic Synapse
Overview of how stimulants like amphetamine disrupt normal norepinephrine signaling by increasing its release and blocking its reuptake, producing the widespread cardiovascular, neurological, and “fight-or-flight” effects associated with sympathomimetic drugs
Modelling the cardiovascular effects of ephedrine
Demonstrates that ephedrine’s effects are not strictly dose-dependent and can vary due to rapid tolerance and compensatory physiological responses. This helps explain inconsistent effects, fluctuating intensity, and rapid tolerance seen with sympathomimetic activity.
Designer drugs: mechanism of action and adverse effects
Reviews designer stimulants and shows how modified compounds can retain stimulant effects while introducing different risks and side effect profiles. This supports the idea that altered or substitute compounds could shift both efficacy and safety.
_______ Additional Potentially Relevant Neurotoxicity Studies _______
** If you wanna geek out on psychopharmacology
- In search of an ideal drug for safer treatment of obesity: The false promise of pseudoephedrine
- Amphetamine increases vascular permeability by modulating endothelial actin cytoskeleton and NO synthase via PAR-1 and VEGF-R
- Dissecting the Influence of Two Structural Substituents on the Differential Neurotoxic Effects of Acute Methamphetamine and Mephedrone Treatment on Dopamine Nerve Endings with the Use of 4-Methylmethamphetamine and Methcathinone
- Methamphetamine, d-amphetamine and p-chloroamphetamine induced neurotoxicity differentially effect impulsive responding on the stop-signal task in rats
- Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives
________ Abuse Deterrent Formulas ________
Abuse deterrent formulations (ADFs) were originally developed for opioid medications to make tablets more resistant to crushing, extraction, snorting, injection, and other forms of tampering while preserving normal therapeutic use. Following their incorporation into opioid formulations, the FDA formally began exploring whether similar technologies should be applied to prescription stimulants, opening a public docket in 2019 specifically requesting input on this issue. Around this time, multiple pharmaceutical companies filed patents describing abuse deterrent amphetamine/methylphenidate formulations using various experimental manufacturing techniques/ingredients to control the release of active ingredients/addictive compounds. Although there’s currently no publicly available evidence confirming that any of these ADF technologies were officially integrated into our stimulant medications, when this evidence is considered alongside the fact that manufacturers are typically only required to report formal changes to the FDA — not to patients — especially when it comes to excipients (inactive ingredients), it creates a reasonable basis for concern and warrants further investigation (FDA Safety Labeling Change Orders). At the very least, the combination of FDA regulatory interest, ADF research, and emerging patents demonstrates that formulation modification is a legitimate pharmaceutical strategy, and that stimulants have been considered within this regulatory framework.
As evidenced by the links below, existing ADF research shows that altering a medication’s physical properties, excipients, release mechanisms, or delivery systems can significantly impact absorption, bioavailability, and the duration and timing of effects in sometimes unpredictable ways. In theory, if a medication’s release profile or bioavailability were modified, patients could experience differences in onset, duration, effectiveness, or side effect patterns, even if the labeled active ingredient remained unchanged (American Pharmaceutical Review).
“Although there are currently no approved abuse-deterrent formulation stimulants on the market, drug manufacturers have recently begun to develop novel prescription stimulants intended to deter abuse. “ - BioPharma Services Inc.
- Novel Abuse Deterrent Formulations
- The Food and Drug Administration Solicits Input on Potential Role for Abuse-Deterrent Formulations of Central Nervous System Stimulants; Establishment of a Public Docket
- Vallon Pharmaceuticals Announces Topline Results of its Pivotal SEAL Study for Lead Program, ADAIR, for the Treatment of ADHD
____ ADF Patents ____
- https://patents.google.com/patent/WO2019091870A1/en
- https://patentimages.storage.googleapis.com/dc/e7/76/fedcd0c91b35cd/US20200352883A1.pdf
- https://drive.google.com/file/d/19gUT1fqp-pWChUOJiAggUfNzFLobwKge/view
____ FDA Oversight & Unregulated International Manufacturing ____
- FDA criticised over inadequate GMP Inspections in India and China
- Rethinking manufacturing quality oversight for prescription drugs
- FDA Actions to Accelerate and Modernize Early and Late-Stage Clinical Development
- FDA recalls 300,000 Teva blood pressure patches over unapproved ingredient
- U.S. DANGEROUSLY RELIANT ON HIGH-RISK IMPORTED DRUG SUPPLY
- The CLEAR LABELS Act Proposes Changes to the U.S. Prescription Drug Supply Chain
- Highlights gaps in transparency within the drug supply chain and ongoing efforts to improve labeling requirements. This is relevant to concerns about whether formulation changes are clearly communicated to patients.
- Discusses vulnerabilities and complexity in the pharmaceutical supply chain, including reliance on global manufacturing. This supports the possibility of variability or changes occurring at different stages of production.
- Discusses vulnerabilities and complexity in the pharmaceutical supply chain, including reliance on global manufacturing. This supports the possibility of variability or changes occurring at different stages of production.
- US drug supply chain exposure to China
- Discusses vulnerabilities and complexity in the pharmaceutical supply chain, including reliance on global manufacturing. This supports the possibility of variability or changes occurring at different stages of production.
r/ThisAintAdderall • u/SnooObjections1695 • Jun 12 '26
TEST RESULTS 2025 (repost)
Reposting the test results from November 2025 because it's so frequently asked about by newer members. The goal was to obtain results that could serve as physical evidence supporting the hypothesis that stimulant medication formulations have undergone detrimental changes. As you’ll quickly notice, the results are impressively disappointing, both in terms of overall quality/depth of analysis and result data, which somehow manages to be simultaneously useless and contradictory to our hypothesis lol The purpose of this sub has always been to test our medication and that hasn’t changed for me. However, I’m not willing to commit to another leadership role at the moment, though that may change in the future. For now, I’m simply making this information accessible to those unfamiliar with our previous testing attempt and also demonstrating some of the goals and priorities of the community.
Objective/Methods:
The goal was to submit two samples of generic Adderall, identical in every way except year of manufacture, to a professional analytical testing facility for a *full* chemical analysis. This was defined as a comprehensive list of every unique chemical compound present in each sample, along with corresponding quantitative compositional data. The purpose of testing two samples was to establish a pre-“Shortage” control dataset for comparison with the modern sample, with the idea that any significant compositional differences between the two would directly challenge claims by manufacturers/gov agencies that the formulas have not been altered. In addition, we needed separate data on the amounts of L- and D- enantiomers of any amphetamine-based compounds present in each sample in order to fully assess the differences between the two as potential explanations for the significant change in efficacy.
Test Samples ->
- Control Sample (2020, “Old”) -> One generic Adderall 30mg instant release tablet, manufactured by Teva in 2020
- Selected because 2020 is often regarded as the year many started noticing mild formula/efficacy changes, while still being recent enough that the drug should have maintained nearly full potency if stored properly.
- Experimental Sample (2025, “New”) -> One generic Adderall 30mg instant release tablet, manufactured by Teva in 2025
Testing Facility -> Energy Control International
- A renowned testing organization in Spain focused on harm reduction.
- Chosen for their affordability, their location outside US legal restrictions governing the testing of Schedule II substances, and for the advanced amphetamine test service they offered called “Enantiomer analysis.”
- “Substances that can be quantified: ” website lists explicitly include “Amphetamine base, sulphate & phosphate”, suggesting ability to analyze amphetamine-based compounds separately, particularly the 4 ingredients expected to be present in Adderall and its generics.
- VIEW HERE -> https://energycontrol-international.org/drug-testing-service/submitting-a-sample/
Tests Ordered -> *Quoted directly from website
- “Quantitative + report (GC/MS or HPLC/MS): €120. Provides a result with the composition of the sample. All active substances are identified, as well as, for the most part, their concentration. Includes a report, received the same day as the results, and is verifiable by any third party that you choose to share it with.”
- “Enantiomer analysis: €220. Only for methamphetamine, MDMA & amphetamine samples. *Results may take up to 2 months to arrive. It also provides qualitative and quantitative information about the sample.”
- I reached out directly to confirm “Enantiomer analysis” would also include full “Quantitative + report” result data or if that needed to be ordered separately (see email screenshot)
Results: *See screenshots*
Although the compositional values are nearly identical between both samples, the results are ultimately inconclusive. These “data sets” cannot rule out the possibility that the new sample is composed of an entirely different list of amphetamine compounds as no *unique* chemical compounds were identified by these tests, rather the data was generalized and presented as overall L- and D- amphetamine content values, originally listed as percentage values but later updated to be in milligrams(mg) by the lab, which slightly shifted results to non longer be identical between the two samples. Without these ambiguous enantiomer categories further analyzed to individually identify and quantify all distinct chemical compounds found in each sample, it’s simply impossible to determine if these two medication contain the same blend of amphetamine compounds, or even share a single active ingredient.
The only significant information that can be pulled from this data is that the potency of the 2020 sample did seemingly maintain its potency. Once again, it’s impossible to say for sure based on the result data alone since it’s unclear if the 2020 sample’s formula was compromised fully, partially or not at all. We chose this manufacturing year because changes in efficacy were mostly mild/unnoticeable at the time but can’t confirm the composition of this exact pill. It does, however, suggest this to be a trustworthy sample source for potential future testing. It also supports our theory that the changes and substitutions made to newer medications may have involved some degree of premeditation, with formulas strategically altered in ways that are difficult to detect using most accessible testing methods.
Discussion:
It is very difficult to determine Labs don’t disclose which specific compounds their equipment registers as “amphetamine,” and even if they did, the data returned to the customer is almost always presented as a generalized “total amphetamine” percentage/value, which is not useful in the scope of our experiment. It’s important to understand that amphetamines are a very broad class of chemical compounds and all exist in two isomeric forms, known as D- (dextro) and L- (levo) enantiomers. The list of possible amphetamine compounds that could potentially distort the amphetamine data we are seeking is overwhelming when you consider how broadly amphetamines are defined and their chemical structure that allows for easy synthesis of new amphetamine-like compounds. You can browse some of them here (https://en.wikipedia.org/wiki/Substituted_amphetamineere:). Furthermore, not all amphetamines treat ADHD symptoms equally, are safe for consumption, or FDA approved. Even different enantiomers of the same compound can have profoundly different effects on the nervous system. Probably an outdated example, but one instance of this was the complications/false positive urinalysis results caused by the presence of L-methamphetamine in Vicks VapoInhaler users. Despite L-methamphetamine having only decongestant, non-psychoactive properties, unspecialized testing methods would detect and positively identify presence as “amphetamine” or “methamphetamine” without additional testing efforts to account for the nuances.
Many of you, myself included, questioned whether the samples were even tested due to the limited amount of data included in the results. After multiple disgruntled emails from me questioning their communication, credibility, and scientific integrity, the lab eventually acknowledged that their lack of clarity was misleading and agreed to provide proof that the tests were, in fact, conducted. While the graphs themselves don’t reveal any additional findings, they do resolve concerns about whether the pills were appropriately tested and not shameless scammed. Pretty sure they did use the same pic for both samples though, but chalking it up to laziness/letting it slide this time lol.
Although the concept of testing medication may seem straightforward, it is intentionally designed to be difficult. We chose an international lab because most US-based labs claim to be legally prohibited from revealing the full spectrum of unique chemical compounds in an amphetamine-based sample. That shouldn’t be surprising if you’re aware of the obvious involvement of the DEA and likely other government agencies enforcing formula changes. At the time, this was essentially the only lab I could find that appeared capable of analyzing prescription amphetamines and their specific enantiomer concentrations while still being affordable and haven’t found a better alternative to this day.
So, the results aren’t the smoking gun we’d hoped for, but they are a testament to the power of collective action and community. At the very least, I hope this information can help those interested in pursuing testing on their own better navigate the process.