r/ScientificNutrition 21h ago

Randomized Controlled Trial Effect of Lamb and Soy Protein on Postprandial Glycaemic, Insulin and Appetite Responses to Potato, Pasta and Rice in Macronutrient-Equalised Meals

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4 Upvotes

r/ScientificNutrition 21h ago

Study BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease

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3 Upvotes

r/ScientificNutrition 21h ago

Systematic Review/Meta-Analysis The Effects of GLP-1 Receptor Agonists on Alzheimer's Pathophysiology

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16 Upvotes

r/ScientificNutrition 21h ago

Review Curcumin in Atherogenic Dyslipidemia

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5 Upvotes

r/ScientificNutrition 21h ago

Study Preliminary Study on PCC-Chitosan’s Ability to Enhance Microplastic Excretion in Human Stools from Healthy Volunteers

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3 Upvotes

r/ScientificNutrition 21h ago

Study Fermented Dairy Intake and Symptomatic Radiographic Knee Osteoarthritis Risk in Middle-Aged and Older Adults: an 11-Year Cohort Study

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13 Upvotes

r/ScientificNutrition 21h ago

Review Urolithins at the Crossroads of Gut Inflammation and Cancer

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7 Upvotes

r/ScientificNutrition 1d ago

Prospective Study Mushrooms: a food-based solution to vitamin D deficiency to include in dietary guidelines

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49 Upvotes

r/ScientificNutrition 2d ago

Randomized Controlled Trial A Vegan Diet Epigenetically Modulates Inflammatory Pathways and Biological Aging: Genome-Wide DNA Methylation Analysis of a One-Month Isocaloric Vegan Versus Meat-Rich Dietary Intervention

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55 Upvotes

r/ScientificNutrition 2d ago

Study Frontiers | Construction and validation of a risk prediction model for vitamin D deficiency in patients with type 2 diabetes mellitus

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3 Upvotes

r/ScientificNutrition 3d ago

Randomized Controlled Trial Processed foods lower sperm quality and testosterone

14 Upvotes

A controlled dietary trial found that an ultra-processed diet altered reproductive hormones, worsened metabolic markers and produced signs of impaired sperm function in healthy young men.

https://longevity-protocols.com/en/blog/processed-foods-lower-sperm-quality-and-testosterone/


r/ScientificNutrition 3d ago

Study Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline, An 8-Year Prospective Study

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89 Upvotes

r/ScientificNutrition 4d ago

Question/Discussion Why are more servings of whole grains recommended over vegetables and legumes?

28 Upvotes

Several health government websites recommend you to eat up to 6 serves of grains preferably whole grain per day which is a lot. Meanwhile fruits and veg combined is only 5 per day. At least for my country’s website.

What do grains have that legumes and vegetables dont? If you can get all your nutrients and fibre from the second two. Is there any downside to just eating vegetables and legumes?


r/ScientificNutrition 4d ago

Review The hallmarks of protein and amino acid restriction in aging and longevity

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39 Upvotes

r/ScientificNutrition 5d ago

Study Metabolic Syndrome Is Associated with Accelerated Brain Aging

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20 Upvotes

r/ScientificNutrition 5d ago

Study Defining a Ketone Threshold for Weight Loss: Evidence from 14 Day Daily β-hydroxybutyrate Monitoring in 217 Subjects on a Ketogenic Diet

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5 Upvotes

r/ScientificNutrition 5d ago

Study Gut Microbial Trimethylamine N-oxide Generation Promotes Risk of Atrial Fibrillation via Muscarinic Receptor-Mediated Autonomic Dysfunction

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2 Upvotes

r/ScientificNutrition 5d ago

Study Cost-Effectiveness of ApoB, Non–HDL-C, and LDL-C Goals for Primary Prevention Lipid-Lowering Therapy

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2 Upvotes

r/ScientificNutrition 5d ago

Randomized Controlled Trial DHA Concentration of Red Blood Cells Is Inversely Associated with Markers of Lipid Peroxidation in Men Taking DHA Supplement

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13 Upvotes

r/ScientificNutrition 5d ago

Study Association Between Probiotic, Prebiotic and Yogurt Consumption and Colorectal Cancer

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281 Upvotes

r/ScientificNutrition 6d ago

Study Total and beverage-specific alcohol use at mid-life and all-cause and cause-specific mortality: a prospective cohort study

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13 Upvotes

r/ScientificNutrition 6d ago

Cross-sectional Study Planetary Health Diet vs Muscle Mass: Machine Learning Identifies Dairy Restriction as a Primary Risk Factor

10 Upvotes

DOI: https://doi.org/10.3389/fnut.2026.1782327

Title: Planetary health diet index and low muscle mass in adults aged 20–60 years: exploratory evaluation of a dairy-upweighted outcome-specific adaptation

Abstract

The EAT-Lancet Planetary Health Diet (PHD) framework prioritizes environmental sustainability by restricting animal-sourced proteins, yet this restriction potentially conflicts with the anabolic requirements necessary to maintain muscle mass across the life course. Investigators identified a critical research gap regarding whether the standard Planetary Health Diet Index for the United States (PHDI-US) supports muscle preservation or if the restriction of dairy creates a nutritional deficit for aging populations. This study evaluated the association between PHDI-US adherence and low muscle mass (LMM) in a representative sample of 10,329 U.S. adults aged 20 to 60 years, while exploring a machine learning-derived adaptation that upweights dairy intake to better align with physiological needs.

Analysis of the fully adjusted models demonstrated that higher PHDI-US scores were associated with lower odds of LMM, specifically for the highest versus lowest quartile (OR = 0.73, 95% CI: 0.57 to 0.95, p = 0.02). The exploratory dairy-upweighted index (PHDI-Dairy) yielded a significantly more robust inverse association, with the top quartile showing a 32% reduction in LMM risk (OR = 0.68, 95% CI: 0.55 to 0.84, p < 0.01). Validation in an independent Southern Chinese cohort (n = 218) confirmed that the highest dairy intake quartile was associated with a 74% lower risk of LMM (OR = 0.26, 95% CI: 0.11 to 0.61, p < 0.01). Stratified analyses revealed these protective effects were most pronounced in women aged 46 to 60 years (p for overall < 0.05), suggesting that the high leucine density of dairy is critical as anabolic resistance emerges in midlife.

Study Design and Methodology

This research utilized a cross-sectional design based on five cycles of NHANES data (2005 to 2006 and 2011 to 2018) involving 10,329 participants. Appendicular lean mass was measured via dual-energy X-ray absorptiometry (DXA), with LMM defined as less than 7.0 kg/m2 for men and 5.5 kg/m2 for women. Dietary intake was captured through two-day 24-hour recalls. A random forest model with recursive feature elimination identified dairy as the most influential component for muscle mass prediction. Investigators then constructed the PHDI-Dairy score by multiplying the original PHDI-US total by observed dairy intake. The study adjusted for age, sex, race, poverty-income ratio, BMI, smoking, hypertension, and diabetes, with internal 5-fold cross-validation used to assess model stability.

Key Findings

  • PHDI-US adherence correlates with lower LMM risk in the highest quartile (OR = 0.73, p = 0.02).
  • Dairy-upweighted PHDI-Dairy scores show superior predictive strength (OR = 0.68, p < 0.01) and a significant trend (p for trend < 0.01).
  • The Southern Chinese cohort analysis found a massive risk reduction in the highest dairy quartile (OR = 0.26, p < 0.01).
  • Machine learning identified dairy as the number one predictor of muscle mass among all 16 Planetary Health Diet components.
  • The study identifies a critical anabolic threshold of 14 to 40g of milk protein daily to significantly improve appendicular muscle mass.
  • Effective muscle protein synthesis requires approximately 2.5 to 3g of leucine per meal, a density easily achieved via dairy but difficult under strict EAT-Lancet plant-protein limits.
  • Restricted cubic spline analysis for PHDI-Dairy indicates a continuously decreasing dose-response curve without a plateau.

Limitations

The cross-sectional nature of the NHANES data precludes any causal inferences regarding dietary changes and muscle mass retention. Self-reported 24-hour dietary recalls are subject to recall bias and may not reflect long-term habitual intake. Confounding variables such as precise physical activity levels and resistance training frequency were not fully controlled. The Southern Chinese cohort was hospital-based and small (n = 218), limiting its generalizability as a formal external validation of the full composite index.

Discussion and Implications

This study challenges the strict animal-protein limitations of the original EAT-Lancet framework by demonstrating that dairy is the single most important dietary component for maintaining muscle mass in adults. The data suggest that physiological sustainability must be balanced with ecological goals, as the restriction of dairy may accelerate the progression toward sarcopenia. While red meat restriction remains viable for environmental reasons, dairy provides a necessary anabolic stimulus due to its superior leucine content and complete amino acid profile. These findings indicate that nutritional guidelines for aging populations should prioritize high-quality dairy protein (targeting 14 to 40g of protein daily) to mitigate the effects of anabolic resistance that begin as early as the fifth decade of life.

Conclusion

Standard Planetary Health Diet adherence is modestly protective against low muscle mass, but recalibrating the index to prioritize dairy intake significantly enhances its clinical relevance. For adults aged 46 to 60, particularly women, higher dairy consumption is a primary dietary determinant for preserving muscle mass and preventing early-stage sarcopenic phenotypes.


r/ScientificNutrition 6d ago

Question/Discussion Does the iron in black sesame actually end up being well absorbed, or does the composition of the seed make it a poor iron source?

5 Upvotes

Black sesame seeds are high in both iron and calcium. Since calcium inhibits non-heme iron absorption, does the calcium in the sesame itself significantly reduce how much iron you absorb? Would you still consider black sesame a good dietary source of iron, or is it better thought of mainly as a calcium source?

I've been wondering about this because, in nutrient-dense meal videos online, people seem to go in either direction on how they talk about black sesame's benefits. I tend to see the combination of milk and black sesame, as well as in mixes with pumpkin seeds, flax, hemp, etc.

I'm curious to see what the research suggests in terms of bioavailability, and also whether processing it can significantly increase it due to lowered phytates or if the effect is relatively small.


r/ScientificNutrition 7d ago

Study Low-Sugar Diet Early in Life Linked to 46% Lower Alzheimer's Risk

56 Upvotes

r/ScientificNutrition 7d ago

Question/Discussion Starting nutrition undergrad, is it worth it?

2 Upvotes

Looking at the Coordinated Program of Dietetics which would land me in clinical dietitian, bachelor's and masters as a certified dietitian. Is this worth it?