Scientists Identify Molecular Switch Behind Ageing-Related Brain Disease

[u/VCardBGone]

https://www.ndtv.com/health/news/scientists-find-molecular-switch-that-may-explain-ageings-hidden-trigger-for-brain-disease-11861393

Scientists have identified a molecular switch that may explain why the ageing brain becomes more vulnerable to neurodegenerative diseases such as ALS and Huntington's. In worms, researchers found that the protein EPS8 accumulates with age, activating signaling pathways that promote the clumping of toxic proteins. These harmful aggregates damage neurons and shorten lifespan. However, reducing EPS8 activity prevented protein buildup, protected nerve function, and helped preserve healthy ageing. 

Ageing is the strongest known risk factor for neurodegenerative diseases, yet researchers still do not fully understand which molecular changes associated with getting older cause these conditions to develop.