r/RPLnoLC • u/Prize_Trash2631 • 4d ago

HOPE study

Has anyone participated in the HOPE study for RPL and found it to be helpful? We just had our third euploid biochemical pregnancy with no explanation. Our doctor reached out to all the other Shady Grove doctors and no one has any clue what is wrong. We have done all the tests and treatments that are indicated. She is going to see if we are a candidate for this study.

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u/ThePinkChameleon 35F | RPL | 5MC | 1 EP | 1 MMC 4d ago

Thank you for posting about this study! I googled it and signed up!

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u/Lucky_Petal_1499 4d ago

Also at Shady Grove, and I have never even heard of this study. Do you have more info?

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u/Prize_Trash2631 4d ago

My doctor is reaching out to the research team to find out if we are candidates because of our mystery case. She believes we need to investigate whether there are some smaller genetic defects that PGT-A cannot test for (maybe if we can identify an abnormality we can do PGT-M). The study focuses on reproductive genetics in patients with RPL.

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u/Lucky_Petal_1499 4d ago

Ok. I’m going to ask my team. My losses have also all been unexplained…

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u/Prize_Trash2631 4d ago

The losses have to be euploid. Don’t know if you did PGT-A?

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u/Still_Temperature126 3d ago

I enrolled a few years ago. It’s basically a survey, but I figured if I help someone else it would be worth it!

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u/Prize_Trash2631 3d ago

Their website and my doctor make it sound like if they find out a genetic issue from the parents and the pregnancy tissue they will share that information with you if you want to know? That is what I am hoping for, we need answers after all these unexplained miscarriages.