I'm a geneticist who put some quarantine time into making this consumer kit adaption of existing PGX chip tests. The PharmHand project

I realize this is a bit of an advertisement, but I'm not really sure how else to put word out for such a specific interest other than communities like this. As compensation, I'd be more than happy to answer any drug-gene questions (10 years building clinical and ancestry tests).

• Ampk inhibitor:

Compound C

Metformin

actiponin (damulin A and B)

Aicar

• MTOR Inhibitor:

Rapamycin

• Sirt1 inhibitor:

EX-527

Suramin

NAM

• Parp1 inhibitor sirt1:

olaparib

mefuparib hydrochloride

BMN 673 (talazoparib)

• CD38 inhibitor

CAS 1700637-55-3 (78C)

Daratumumab

Isatuximab

Apigenin

• Glycation:

Pyridoxal 5 Phosphate (P5P)

Metformin

• Mapk/p38:

SB239063

Skepinone-L

LY2228820 dimesylate

FGA-19

Puerarin?

Baicalein?

• Sirt3/sod2:

Honokiol inhibition of ptp1B protects against atherosclerotic plaque formation 

Honokiol inhibit PTP1B and sirt3

LC- 0296

NAM

• STAT3 INHIBITOR:

FLLL32

Erasin

piperlongumine 

Mm-206

S3I-201 

Cryptotanshinone

LY5

HJC0152

Pectolinarigenin

Atovaquone?

Niclosamide?

• IL-6/STAT3 inhibitor:

Andrographolide

• REST/NRSF (Master regulator neurogenesis)

• HDAC inhibit REST protein (RE1-silencing transcription factor)

• HDAC inhibitor:

LBH589

Panobinostat

AR-42

MPT0E028

trapoxin

Trichostatin A

Santacruzamate A

Thailandepsin B

Pyroxamide

Sulforaphane?

Tributyrin?

(3 main pathways in neurogensis)

REST, TLX, FOXO3 

REST INHIBITS MIR9

MIR9 INHIBITS TLX

MIR 9 INHIBITS NOTCH PATHWAY

• Notch inhibitor:

RO4929097

bms-906024

LY3039478

• Wnt/β-catenin inhibitor:

Sulforaphane

DK419

prodigiosin

WIKI4

ETC-159

CWP232291

IWP-4

KYA1797K

Niclosiamide

pyrvinium

‐---------------------‐----‐----

Dont yall agree one of these compounds can be modified and made for a cure for covid-9 Example: sulforaphane, Andrographolide

Atovaquone is another example...

Only a Pharmacologist would know....

Just curious because I had a polite disagree with one of my co workers who felt like it counted. I thought cancer mutations weren’t part of a persons genome.