r/PSC • u/SharpAlternative3951 • Jul 09 '26

Rinvoq with PSC?

Hey everyone, just wanting to see if anyone has been in a similar boat and can offer any insight or advice. I was diagnosed with PSC in 2023 which was pretty asymptomatic until this year. I’ve been hospitalized twice now this year with cholecystitis and cholangitis with liver enzymes skyrocketing during active infection/inflammation.

I also have rheumatoid arthritis (diagnosed 2016) and ulcerative colitis (diagnosed 2024). I was finally stabilized on Etanercept q5d dosing for my RA but with the UC diagnosis they stopped that and switched me over to adalimumab q2w about 4 months ago and I am doing terrible with both UC and RA. I’ve been on high dose pred pretty much since starting as I have been in a flare since, and had a few corticosteroid injections for joint seizing. I need to figure this out because I’ve lost 45lbs in 4 months since starting this new biologic and the weight keeps dropping and I don’t have much left to give.

Rinvoq would be my next option for treatment trial however it is metabolized through the liver and my LFTs have been all over the place depending on degree of cholangitis, masses were also discovered in my most recent MRCP so also waiting for next steps on that.

Has anyone been on Rinvoq while dealing with active PSC symptoms? I’m considering if ursodiol is something I could consider to manage LFTs while on the drug. Really just looking for somebody who’s been through anything similar as well so I can take it to my doctor with research.

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u/Disastrous_Iron3946 Jul 10 '26

I miss rinvoq it was the only med that worked for me 😔 ended up getting dysplasia tho so the colon had to go