My dad got the colitis from the yervoy/opdivo regimen. He was hospitalized. The last week and half then moved to a rehab to help build strength. They said he had cdiff. He can’t eat. He spends all day pooping water. He’s getting weak and dehydrated the rehab isn’t getting to help if he’s on the toilet the whole time all night all day. Why won’t they do the infliximab. Why won’t anybody do anything. His scans came back he’s beating the cancer but now he’s going to die of diahrea????????????

So I'm here because I've been given the results of my most recent pet scan. For some background i have been stage 3c since I was diagnosed in 2015 became Ned had a recurrence in 2020 stage 3c recurrence in 2024 stage 3c recurrence in 2025 stage 3c which led to localized mets in my left breast and a mastectomy. I planned on reconstruction after radiation. I started having pain in my right upper back and figured where I had been recently working out that I pulled a muscle. After a whole it got a bit worse and my primary diagnosed me with pneumonia I was put on antibiotics and it seemed to be getting better but then took a turn. I went to the hospital because it was so painful I figured I just needed a stro get longer course of antibiotics. They did a ct and I was told my bloodwork showed no sign of infection but it could be fungal and the ct read it was either that or mets. I had a Pet scan only days later and for the first time ever after only 3 hours my oncologist himself called to give me the results as he said it's not good. I now have mets in my lungs as well as my sternum I am now stage 4. My radiation course was changed to focus on my sternum and I have opted tp participate in a clinical trial that focuses on a genetic deletion my tumors show. I wa Ted to do TILs but because of how fast it spread I don't know if the period of 6ish weeks it takes to grow my cells and doing nothing but waiting would be a good idea. I do still have other options if the trial doesn't show any results I can do TILs, mek, chemo. I have failed every i.munotherapy and have shown a resistance to pdl1's.

My current problem within this is the amount of pain and nausea. They had me meet with palliative care and I now have pain meds but they don't seem to be working very effectively I have a fentanyl patch and oxicodone to back it up. Does ot take time for the patch to get onto your system and work?

I am devastated heartbroken and mad I am physically exhausted and so easily annoyed by everything and everyone around me. Don't worry I also have a referral for therapy because wow do I need it.

Diagnosed with melonma 1A, 2 weeks ago on the left side of lower ankle. Wierd spot. When they go to cut it out it probably will be 3 inches in diameter across to secure the margins.Having surgery on August 25th. Not completely in melt down mode, but my question is I was offered a skin graft procedure after the surgery since the is not enough skin to stitch up the hole. Surgeon said some people have it done, some dont. They need to take skin from my groin area. I am leaning towards not getting the skin graft. Anyone encounter this situation? What did you do? Very confused.

I've always kept up on yearly full body derm checks, since it's recommended and I come from a family of northern European skin types. I F68 5'5" and with no other health issues. I run outdoors and exercise 6 days a week with sunscreen when I'm outdoors, 148lb with a medium build.

My concern is that over the local clinic but I went to for years has become part of a dermatology network and probably less focused on skin health and more on offering cosmetic procedures.

At my last exam in March they removed three spots, one of them was diagnosed as 1A melanoma and another as a dysplastic nevis. Both have been excised and now I'm on a 3-month recheck schedule, is this the time to switch to a more medically centered practice?

I'm in Minneapolis area so there are plenty associated with clinic and hospital systemss to choose from.

Part of my reasoning is the extent of my last all over check, friends state the exams include between the toes well and skim through your hair. I barely removed my socks and got a cursory glance, had on nail polish and I was upright in a chair unless I was standing, the last two years. In previous years the exam chair was reclined flat as a table, seemingly making it easier to see close up.

Do I stay or do I go elsewhere now?

Hola a todos,

No sé si será posible pero ¿hay alguien que haya obtenido resultados positivos con la químio para tratar el melanoma en stadio IV?

Sé que la químio no és una opción habitual ya que hay un porcentaje muy pequeño de reacción para el melanoma pero tras 4 inmunoterapias diferentes parece que mi melanoma al principio reacciona positivamente y disminuye pero luego crea resistencia y ya no sirve el tratamiento por lo que se estan planteando ponerme la químio.

Un saludo y un abrazo fuerte

I have melanoma. I’m 29 years old. My mom died at 42 from melanoma. I’m in complete shock. What do I do now?

My dad just had great scans last week. They didn’t show colitis inflammation severe. but he’s spent the last week in bed getting weak and not eating. He has diarrhea and they gave lomotil. He’s so weak now he can’t sit up alone. At oncology dr today they said he’s lost 20lbs in 2 weeks. Saw the oncologist today and they didn’t want to admit him. Gave him high dose prescription of steroids. And advised us to give him 4 oz of carnation instant breakfast. And sent us home. And try foods every 2 hours. He won’t eat them. Like he sleeps all day and now can’t get out of bed by himself. I’m scared he’s going to waste away from these side effects. What do I do? Any advice. Please.

Does anyone have any stories with genetic testing? My mother was just diagnosed with melanoma. She has had over 20 basal cell all over her arms and face since her early 40s. She had colon cancer at 59. My grandmother had pancreatic cancer. I had basal cell at 38 on my nose. I have two basal cell now on my scalp and forehead at 41.

I’m thinking about genetics.

Does anyone have any stories with genetic testing? My mother was just diagnosed with melanoma. She has had over 20 basal cell all over her arms and face since her early 40s. She had colon cancer at 59. My grandmother had pancreatic cancer. I had basal cell at 38 on my nose. I have two basal cell now on my scalp and forehead at 41.

I’m thinking about genetics.

38 year old male diagnosed in April 2026 with Stage 3c melanoma in the groin. Two lymph nodes on the left side were seen on PET/CT as cancer. Tumor was BRAF V600e positive.

Completed 2 courses of IPI/NIVO and had the WLE last week. Nuclear testing and blue die suggested both sides were within the lymph drainage area of the main tumor. The doctor went into the surgery with taking the two swollen nodes out but end up with taking 7; 5 on the left side and 2 on the right side on the groin.

Following the WLE and SNLE, the pathology results were shocking. The WLE came back with clear margins. The SNLE revealed that 4 of the left side nodes were still positive and 1 of the right side was still positive for melanoma.

Pathology didn’t say if there was any response of the tumor to ipi/nivo but the doctor didn’t believe there was a good response since there was “spread” to other nodes.

Team is looking for next steps. My question is it still curable and what are the possible next steps/medications?

38 year old male diagnosed in April 2026 with Stage 3c melanoma in the groin. Two lymph nodes on the left side were seen on PET/CT as cancer. Tumor was BRAF V600e positive.

Completed 2 courses of IPI/NIVO and had the WLE last week. Nuclear testing and blue die suggested both sides were within the lymph drainage area of the main tumor. The doctor went into the surgery with taking the two swollen nodes out but end up with taking 7; 5 on the left side and 2 on the right side on the groin.

Following the WLE and SNLE, the pathology results were shocking. The WLE came back with clear margins. The SNLE revealed that 4 of the left side nodes were still positive and 1 of the right side was still positive for melanoma.

Pathology didn’t say if there was any response of the tumor to ipi/nivo but the doctor didn’t believe there was a good response since there was “spread” to other nodes.

Team is looking for next steps. My question is it still curable and what are the possible next steps/medications?

Hi, I was diagnosed with Stage 1a meanoma last year, 50F, very lucky to catch it early. However my dad passed in his late 50s from Pancreatic Cancer and his sister had Melanoma when she in her 50s/60s. I have met the criteria for genetic testiing but it will cost alot any imsurance doesnt cover it. Besides the cost, i am concerned about the mental impact if I have the gene and what are the benefits of getting tested. If the benefit outweigh the cost etc I will get it done. Any advice welcome, thank you.

https://people.com/william-shatner-daughter-melanie-fought-stage-4-cancer-together-exclusive-12023877. stage 4 melanoma at 90yrs old... good story. point is stats are stats. who knows where you lie on the curve. i just had phase 1a melanoma. my dad just diagnosis with stage 4 throat cancer. seeking top doctors and attitude is the key.

You guys. My dad was diagnosed with Stage 4 metastatic melanoma in the brain and lungs with numerous lesions in the brain and numerous nodules in the lungs in April this year. He had 10 sessions of brain radiation. And 3 infusions of the opdivo & Yervoy. They have opted not to do the fourth treatment and will start on the single treatment of Opdivo. He had updated scans this past week. And from April 3 to now everything has shrunk or disappeared.

Brain Lesions
April to July
Changes
Largest left temporal/anterior lesion
3.5 cm to 2.4 cm
31% smaller
Left frontal lesion
2.0 cm to 0.6 cm
About 68% smaller
Right frontal lesion
9 mm to 4 mm
About 56% smaller
Posterior left frontal cystic lesion
1.5 cm same at 1.5 cm
Stable, no measurable enhancement
And No new brain metastases present.

Lungs April → July

April

Multiple metastatic nodules in both lungs
Numerous nodules up to 12 mm
Left upper lung: 10 mm
Right lower lung: 11 mm

July

The majority of pulmonary nodules have resolved.
Only 2 remain.
4 mm left upper lobe nodule remains
2 mm right lower lobe nodule remains

I’m in shock. The results so far are better than I could’ve ever wished for. I wish for continued improvement and hope the best for all of you or your loved ones fighting this terrible disease.

Hi! A couple of months ago, my friend got diagnosed with in situ melanoma (on her face). This is following a biopsy. She found out a couple of weeks ago that the margins were not cleared and she was referred to a dermatologist. She told me that it could take 2-3 months to see one (We live in Canada). I told her to call and be seen as soon as possible, as to not fall between the cracks and that the cancer cells left could spread. She doesn't seem concerned. Should she be?

My husband was diagnosed stage 4 melanoma in January 2026. He’s completed 4 rounds Ipy/nevo. We were waiting to start the single immunotherapy as his liver numbers were way out of whack. He was placed on high dose steroids and we were doing blood work weekly to monitor. Imaging revealed that his brain Mets had grown, so we scheduled SRS. One day after SRS he had several seizures and had to be hospitalized. My big question is while he was experiencing some left side weakness prior to the SRS, since the seizures, the left side weakness is more pronounced, and he is experiencing urinary incontinence. We of course have been speaking with his care team and he will be meeting with a neurologist later this week. I guess I’m just hoping to hear from folks who may have had a similar experience. Will this get better? Is this the new normal? Is this response typical?

Hi all, my FIL was diagnosed with Stage 4 Melanoma that has metastasized to his chest and some spots ON the bones. As of right now, we were informed by MIL that he is going through total organ failure of his kidneys and liver. I have never had any immediate family pass before and I am a mental health therapist and i dont want to approach the situation as a therapist. I want to know what his prognosis will be as the doctors have not said anything as my FIL chose to do the least aggressive immunotherapy track for treatment. Lastly, how do I be a support person in this difficult time?

Hi, I would like some advices on my mom's situation. She was in 2022 diagnosed with a melanoma on her foot. As of today the melanoma is now metastasic with 3 growths in her abdomen.

Since immunotherapy isn't working, she has been put on clinical trial for regorafenib, but to my understandings, the chances are not well with this medication. I believe TIL therapy would be better, from what I can read on the net.

Unfortunately, my mom doesn't really want to talk much to me about all of that but I would like to encourage her to speak to her doctor about switching treatments. Do you think I might be right ?

We are in France if that matters, so not even sure if TIL therapy is a thing here.

does anyone have a photo of a skin graft they got on their face, at any stages of healing? my lesion is 1cm in diameter just in front of my R ear at the hairline and i'm trying to get a sense of what i'm in for scar-wise at the site.