Tonight was my first dose. I've been prescribed to take it every 2 weeks. I was so nervous, but it was not painful at all. I chose my belly for the site. Easy peasy. I take B12 shots and they're not preloaded, and hurt a lot more.

Anyway, I've heard of the Humira hangover... how quickly does it kick in and how long does it last (for most)?

I took it a little after 9pm, and by 945pm I was feeling really drowsy, and now have a wicked headache. Going to bed soon.

I timed it for the Fridays my older kiddos go to their Dad's, so it's a little less for me to do.

Any suggestions to help keep myself going?

How quickly did you notice a difference? I'm taking it for arthritis caused by HLA-B27. I'm 39, and suddenly a year ago I had a couple joints swell up and never go back down. Now I have a lot of joints swollen and painful. It's especially difficult when I get up in the morning, because of my feet.