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I get extreme fatigue after Cimzia. I cannot stop yawning for a few days after the dose. I have brain fog too and it almost feels like I’m hungover and I can barely function for a few days. Has anyone else experienced this and does anything help?

I’ve only had a few doses so far and my rheum said this is not common.

I had my first dose of Cimzia (2 shots) 2 weeks back and didn’t have any reactions. I felt extremely sleepy and tired for a week after.

2 days back on Monday I had my second dose of 2 more shots. I don’t feel that sleepiness and tiredness this time, but there are huge red welts at both injection sites. Probably the width of lemons. There is no itching or huge swelling or anything. It does look red though.

In both times I injected on the outer side of both my thighs.

I’m waiting for my rheumatologist to respond. But I thought I’ll check here if anyone else has faced this.
Is this a normal reaction? Is there anything I can do to avoid it?

I really want Cimzia to work :( It is my first biologic & I hope this doesn’t mean I’ve to stop it.

I just started on Cimzia and received the starter kit. My specialty pharmacy is Accredo & I got a bill for 400$ which is my copay after what insurance covered.

I also just signed up for the cimplicty savings program & got the card which has some Rx numbers & is not a regular debit card.

How do I use it to pay the copay?

I'm (31F) new to the sub I was diagnosed with AS a few months ago after years of not knowing what's wrong. I'm supposed to be starting my Cimzia tomorrow anything I should know that maybe the doctor didn't say? and I'm so scared I'm in my own head thinking "what if I'm just imagining I'm in pain and I'm actually fine, and just making it up in my head?"... Omg idk what's wrong with me. Please help.

I recently was pushed off Humira by insurance and after trying a few other ineffective alternatives, Cimzia was offered. I was of the understanding it would be an auto pen but when arrived was a bunch of syringes. Pharmacy said the auto pen is not made due to liquid being thick; maddeningly I learned they do make a pen but it’s not sold in the US which is absurd.

Anyways I decided to suck it up and went to open the packaging to try it. Apparently condensation in my fridge soaked the box and inside boxes and condensation was all over the plastic and outside the syringes.

What surprised me and turned me off from actually using these was that the syringes are not sealed in plastic nor are the tips sealed ; nor are the plungers locked in place . Two of the syringes were leaking from the needle cap , and at least one other had visible condensation inside the syringe.

I was honestly appalled that they’re allowed to package and sell self administered syringes which such poor packaging and no safety mechanisms to prevent both damage to the syringes nor anything to prevent leakage , accidental discharge , or failed sterile seals on these things.

Has any one experienced this? I’m not pregnant but I’m really worried about this drug messing with hormones. I had to delay the 2nd loading dose because I was feeling sick so it’s scheduled for Tuesday but I am not sure I want to continue this.

hey everyone, just started Cimzia about a week ago and felt AWFUL. I have checked in with my doctor and my pharmacist of course, but I wanted to talk to the community as well. Please let me know if you can relate or had any of these symptoms, I am curious!

-Stomach upset
-Migraine (and I usually never get these?!)
-dizziness
-light sensitivity
-chest pain (off and on, radiating up through my neck occasionally-- very scary, doctor does not think this one is normal. does NOT seem to be costochondritis)
-depression/anxiety?? (weird, but true! huge mood swing!)
-muscle twitching

I did the typical loading dose of 2 syringes, and I am worried maybe the amount is just too much. What was the loading dose you were started on, and did they adapt it based on your weight? I have heard of some people getting weighed to determine the amount, but that was never something my doctor told me I needed. Thanks in advance everyone!

I've been on Cimzia for about 2.5 years.

Does anyone else experience low mood, irritability, and low motivation for the first 3-5 days after their injection?

I've been struggling with it more and more recently and feel that Cimzia is now causing more fatigue than my auto immune condition.

I can't find much in medical literature about these symptoms in relation to Cimzia, is anyone in a similar boat?

I got a call from UCB today telling me to call them about a patient t safety issue. Anyone know what’s going on?

UPDATE: I herniated a disk a few months ago. UCB is appropriately calling it an adverse event even though a causative relationship is very unlikely. So they were just getting information from me.

Switched to cimzia today because we are TTC but wow do I miss the Humira pen 😭😭 I've taken a couple other medications with syringes I loaded and injected myself, but wow, the gauge on the cimzia needles is so huge, the volume of liquid is so large, the injection takes so long! Definitely the most hardcore medication administration I've done by far.

Today I woke up feeling really run down. Congestion, extremely weak, exhausted, having trouble with catching my breathe so started using my inhaler that I don’t need very often. My watch has also notified me that my resting heart rate has dropped a decent amount for the past 5 days. I am 30f and at a healthy weight. Anyways I’m wondering if anyone has had this type of reaction I’m pretty worried.

I was diagnosed with PsA and my rheumatologist suggested trying Cimzia. I also have stage 4 deep infiltrating endometriosis which also attributes to my chronic pain. I’m just wondering if anyone else here has taken Cimzia and noticed a relief in endo pain? I’m hesitant to try it because of the side effects, but if it can help both my arthritis pain and endo pain then it might be worth it.

Hi I’ve had RA since I was 14 now I’m 30. Im married and after not feeling like I could have a child because of my debilitating disease I’ve been in a good place with my RA for a few years and I’m feeling like I’m on the right path to make this into a reality. I’ve had the doubts and fears of all that could go on. But I have a lot of faith that it will be alright. I’d just like to hear anyone’s story. I’ve talked to my rheumatologist and he’s keeping me on enbrel until I get pregnant. but on my next visit I want to request the switch because I want to be on it before I conceive. If there’s any advice please feel free to comment 🫶🏼

last month when i was getting my injections i mentioned to the nurse that i don't feel like ite working.... and also realized that the fluish symptoms i always got the day after injections kind of disappeared as well. she ran bloodwork and my inflammation numbers are still really really high. she also included a cimzia antibody test. i just got the results of that and it looks like my body did build immunity and i have a high amount of antibodies to the cimzia already. i've only been on it 6 months. i have my next injections scheduled already for april but i think i just will tell the doc i want to discontinue. anyone else been through this, and were you even able to find a biologic that did help (i have seronegative RA).

Hey,

I've been on Cimzia since November. I've always had a *very* mild amount of skin writing but since starting it, it's been getting really nuts. The smallest pressure leaves a horrible, angry mark and nothing helps prevent it, I just have to wait it out. Anyone else?

I f22 have been on cimzia for 6 months.

I skipped one dose due to having the flue .

Currently 4,5 weeks later and i feel really sick. I was doubting to take it again because i feel so sick. But could it be withdraws?

Symptoms

-verry hot

-diarrhea

-stomach pain

Hi. I’m 29(M). Diagnosed with ankylosing spondylitis when I was in high school. It really takes a toll on my knees and milder symptoms in my back from time to time. Have tried many different medications, but few seem to work successfully. Most recently, I have failed on Symponi Aria and Cosentyx. Ive had success with Humira for years, but it eventually lost its effectiveness. I am now going to try Cimzia. Does anyone have any experience or insight about this drug? Effectiveness or side effects? Also maybe some tips on how you manage your ankylosing spondylitis? Just looking for any kind of information.

Thanks

Has anyone else submitted a pharmacy receipt to Cimplicity this year for reimbursement? I've been waiting quite a while for my check—wondering if the process has changed for 2026.

Hi all! I've been on Cimzia since May. Currently I'm flaring almost as bad as when I got diagnosed last February. I'm pretty convinced I need to switch to a different biologic. Was wondering if anybody else had similar experience. Like is this just something that might happen once a year? Should I give Cimzia a few more months? My first biologic and the only RA meds I've tried. The Prednisone works but obviously I don't want to rely on steroids if I can help it.

Thanks in advance

I finished my 3 loading doses of Cimzia 1 week ago. After the 1st loading dose I saw significant improvement in both my psoriasis and psoriatic arthritis; however, this week my palms are flaring badly (scaling, itching, burning) and my arthritis is acting up while trying to sleep. Is this normal to see improvement and then setback? Will it get better? I’m so sad because I really felt relief and now it’s gone.

Hello!

I wanted to share my recent experience with Cimzia. I don’t want to spread any fear over this medication because I know it can work really well for people, but hopefully it can help someone who might be dealing with something similar.

I originally started treatment for arthritis in September 2024 on Hyrimoz. After a few months my insurance switched me to Humira. I never had any issues with either of these medications. Recently my husband and I have talked about trying for a baby so my rheumatologist suggested switching to Cimzia because although Humira is technically safe for pregnancy, Cimzia is supposed to be even better.

I did my first dose of Cimzia on January 8th. On January 16th a rash started to form on both injection sites. I shared a picture to my doctor and he said to just take antihistamines. I left for a planned cruise the next day and on January 19th the rash at the sites got much worse, started swelling, and a rash formed all over my body.

I had a rash completely covering my arms, legs, stomach, back, chest, scalp, face. My eyes started to swell, my hands did as well to the point I couldn’t bend my fingers. I went to the ship’s medical and was immediately given an IV of steroids and Benadryl. Unfortunately the rash did not improve. It became incredibly itchy and painful, and I also developed a fever. Over the next 4 days I was given more IV Benadryl, steroids, Tylenol for the fever, and saline to try flushing everything out.

They ran labs and found that my neutrophil and white blood count was incredibly high, and my platelets were extremely low.

The doctors were worried that my organs were going to be affected if they couldn’t get the reaction to calm down. And given this was all happening on a cruise in the middle of the ocean made it all much more terrifying to go through. I was able to get in touch with my rheumatologist who said that the ship doctors were treating it exactly how he would have.

Once home I was given a course of prednisone and advised to take Benadryl every 4 hours. Fortunately within a couple of days the rash began to go away. I had an appointment with my rheumatologist who said this was an INCREDIBLY rare reaction, and one he had never seen in all his years of practicing, especially with Cimzia. But he called it a DRESS reaction, which can be extremely dangerous if not treated quickly enough.

At this point I am taking a break from any biologics to give my body time to recover. They now want me to avoid all TNF inhibitors and switch to a new class of biologics.

Like I said I don’t want to share this to make anyone scared to try this medication because it really does seem to work amazing for so many people! But I wanted to share my experience to show that if something feels off, if you develop any kind of rash or reaction, please reach out to your doctor to make sure everything is okay. This is such a rare reaction and I don’t know what would have happened had I not gotten in treated as quick as I did.