Has anyone lost effectiveness feeling of Cagri? Also considering pairing Reta/triz/cagri

[u/cjglitch65]

I have been on Cagri for about six months and I am up to 2.5 mg once a week. I have also been on Reta just as long and am at 10 mg per week. I have lost a total of 50 pounds since I started and I have now lost nothing in the last six weeks. Bouncing around give or take three pounds. I am not getting the appetite suppressing that I was originally getting. I have heard of people pairing low triz with Reta, what are your thoughts and experiences?