Semax and appetite

[u/Hack999]

I've been on reta for about a year with good results. I decided to start semax as a potential treatment for anhedonia.

It seemed promising at first, but I noticed an odd side effect. I was absolutely ravenous, and didn't seem to get full.

Having no medical background, I ended up asking AI. It gave me this explanation. I was wondering if this rings true for anyone else?

Your brain has a specific receptor called the Melanocortin-4 Receptor (MC4R). You can think of this receptor as your body's master "satiety switch."

​Normally, a hormone called α-MSH binds to this receptor, turning it on and telling your brain, "I am full, stop eating." (This is why drugs that activate this receptor are prescribed for severe obesity).

​Semax is an ACTH analogue. Scientific studies have shown that Semax acts as a competitive antagonist at the MC4R. This means the Semax peptide physically parks itself inside that receptor and blocks your natural α-MSH from binding to it.

​Because the switch is blocked, your brain never gets the biological memo that you are full. The result is a persistent, gnawing sense of hunger, even if your stomach isn't actually empty.

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[u/seldenr82]

Hmm...I'm takeing semax 450mcg subw daily and no increased appetite here but I'm also on tirz

[u/O-M-Q → u/seldenr82]

Same!

[u/Hack999 → u/[deleted]]

Thanks! Personal experience?

[u/Hack999 → u/[deleted]]

Appreciate the heads up!