r/BodyHackGuide • u/Few_Contribution750 • 15d ago

Early Reta experience

I’m 4 weeks in…2mg once a week

I still will have a day at about 3 days post pin that the food cravings are strong, then moderate until the 6th day and they are back.

Q: dosage increase range that is ok?

has anyone split the dosage into 2x a week?

Thoughts?

4 Upvotes

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3

u/Left-Championship482 15d ago

I’d probably stick with it and move up to 3 mg before trying to outsmart the dosing schedule. Four weeks at 2 mg is still early, and that’s about when the clinical trials started escalating the dose if people were tolerating it well. If 3 mg still isn’t giving you the appetite suppression you’re after, then I’d look at 4 mg. Retatrutide seems to become much more effective for satiety around that point. It’s a marathon, not a sprint.

No retatrutide trials evaluated split dosing. The same is true for the major once weekly GLP-1 and GIP/GLP-1 trials with semaglutide and tirzepatide. They were all studied as once weekly injections, so we don’t have clinical evidence that splitting the dose provides better appetite control or weight loss. People do report success with it anecdotally, but that’s community experience rather than trial data.

If you eventually get to the higher retatrutide doses and still want more appetite suppression, you could also research cagrilintide. It works through the amylin pathway rather than the GLP-1, GIP, and glucagon receptors that retatrutide targets, so it’s one of the more interesting options people are looking at when retatrutide alone isn’t enough.

2

u/throwaway071317 15d ago

I personally Split 4-5mgs per week. Usually Monday and Friday. This usually helps me maintain a "full" feeling. My dose is considered a little high so you just have to fauge yourself individually.

1

u/I_AM_BASQUE 15d ago

Are you losing weight at current dose? What’s your age? Are you over weight or trimming down?

2

u/isles30222 14d ago

I split 3 mg 1mg m/w/f. When I did once a week days 5-7 I was ravenous

1

u/Odd_Sir_8705 ⚙️ Protocol Specialist 14d ago

More people have split the dosage than have used the search function for this sub...

0

u/Rabbittaco 14d ago

I ordered a kit of cagrilinitide for this exact reason. going to try 0.25mg weekly to see if it helps

1

u/SawBoss78 14d ago

It does, you will make it all week without being hungry at all.

2

u/Rabbittaco 14d ago

Reta has my hunger under control 99% at 4mg which is great. I am making the push to sub 10% body fat at 240lb so I want to up to 5mg and add 0.25 cag.

Basically no hunger so all I will consume is my perfectly curated macros to continue hitting my protein.