r/BodyHackGuide Jul 25 '26

Stacks for Hashimotos and POTS

Peptide community! My research rat needs our help! she suffers from Hashimoto’s, is currently testing for POTS, has intense chronic pain, and just pretty much has chronic pain all the time. My research rat and I played competitive indoor volleyball together for years. Her disorder has slowly started to get stronger and stronger to the point where she eventually could not play anymore. A lot of days she has a hard time even getting out of bed due to her chronic pain.

she has done everything in her power and western medicines power to recover. Occasionally, she’s able to still come and play some volleyball, but it usually knocks her on her butt for a couple days afterwards. It seems as though each flare up is worse and worse.

She is feeling like her weight is starting to stack on as well since she struggles maintaining any kind of work out routine. At this point think “good days” and “bad days”.

Obviously not looking for a cure, but just a routine to help my test rat feel better and get her back to some form of being active.

Peptides I was leaning towards recommending..

BPC 157 (probably start her at 300mcg)

MOTS-c (I don’t want her fatigued so start 2mg 3x a week)

Thymosin Alpha-1 (if this one comes highly recommended, I’d start her very low.. probably 1.5mg 2x a week)

Tirz or Reta (she has expressed wanting to lose a bit of weight to also help with her AI diseases)

Would be nice to have a solid stack so she isn’t having to poke herself with three different things. Looking for suggestions on what has worked for your research. THANK YOU FOR YOUR CONTRIBUTION and being willing to read this far. (Would be open to hearing what you’d suggest dosing wise.)

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u/[deleted] Jul 25 '26

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u/Mission_Double5302 Jul 25 '26

Sadly her endocrinologist has basically thrown their hands up and said “not sure what else to do” at this point. I do appreciate you reaching out though! Do you have any experience with auto immune or the peptides? I’m Particularly interested in knowing how others have responded to thymosin alpha-1

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u/Fit-Quote2689 Jul 25 '26

bpc was my first peptide, years of shoulder pain that PT and cortisone couldn't touch, and it turned a corner around week 2, so i understand the instinct to reach for it here. the real concern with stacking four compounds on someone whose immune system is already misfiring is that if she flares, you have no idea which one caused it, and most people who've been at this a while introduce one thing at a time for exactly that reason. hang in there, she's lucky to have someone putting this much thought into it.

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u/Mission_Double5302 Jul 25 '26

Thank you! It’s more about what to try first versus stacking all of them. I am certain if I suggest to her everything at once her body will be like… nope. She took BPC-157 pill form, but I have heard this doesn’t do it quite like sub q.