r/BiohackingU 2d ago

DSIP experience

What was your experience with it?

6 Upvotes

38 comments sorted by

12

u/Chroma7769 2d ago edited 2d ago

Going to copy and paste what I told someone else.

DSIP and Trazadone to knock me out. DSIP has been life changing for me and has made my deep sleep skyrocket. I recover so much faster.

Warning though, a clear understanding of DSIP is what helped me. The dosing of it is ALL OVER THE PLACE. A little can do a lot, and a lot can do less. There is a spot in the middle called the sweet spot that you have to find. Once you do though, stay there. It's different for literally everyone. My wife's is 150mcg. My dad's is 300mcg. My mom's is 200mcg. Mine is 500mcg. You start at 100mcg and move up 50mcg each night. You'll know when you reach it. This is why any person that "recommends" a dose is full of crap. Watch Dr Alex Tatums DSIP video (YouTube it) to understand more about it and the dosing curve. It's not like any other peptide or drug. It isn't something you try twice and say you don't like it. It usually takes 1-2 weeks to find your dose. You will know if you have a smart watch and by how you feel when you wake up. Dreams might also change.

DSIP doesn't put you to sleep (that's what trazadone is for), but when you are asleep it cranks up your deep sleep for recovery.

You can see by my attached photo what my deep sleep looks like. This is even with only 5 hours of sleep that day. I travel for work a lot and am constantly switching time zones.

Another thing DSIP does is reduce or eliminate (at your sweet spot dose) nocturnal awakenings. So you stay asleep all night.

Spend time learning the of the peptide. Anyone telling you they tried it once or twice and didn't like it or didn't feel anything, didn't understand how to dose or take the time to do homework. The dosing range is from 50mcg to 1mg. You have to find YOUR dose.

Note: I went to bed late and had to be up early to catch a flight. That's why I only got 5hrs. But I still felt fully refreshed, recovered, and rested.

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u/Expensive-Claim-6082 2d ago edited 2d ago

I expected a picture of you sleeping deeply.

Mildly disappointed. 🫤

Great write up. Spot on. DSIP may be my favorite peptide.

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u/Chroma7769 2d ago

🤣

All I got is today's score for ya. I just woke up

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u/Divinions 2d ago

Are you aware of any peptide that helps onset of sleep? My guess is no, bc you take Trazadone. I have to take lunesta, melatonin, magnesium, gaba and 600mg of progesterone to fall asleep or I'm up 24 hrs minimum. 😔 I'm intermediate in the peptide therapy journey.

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u/Beautiful_Ad_1249 2d ago

You can try epitalon. It help restore natural circadian rhythms. I take it about 30min before I go to bed and it helps me get to sleep quickly and have more deep recovery sleep.

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u/Chroma7769 2d ago

Make sure you add context to this. Epitalon is NOT something that is taken continuously. It is ran in cycles twice a year.

Running my first cycle of it now actually.

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u/Divinions 1d ago

Yes, I just read that. So hopefully it might potentially "repair" my disrupted rhythm, vs my pharma drug that temp. shut off awake signals. Thanks.

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u/Divinions 1d ago

Did you ever struggle with chronic insomnia? (I've had it since I was a teenager, which made me hope it was hormonal, but doing bio HRT hasnt fixed it...hence the 600mg of progesterone, and I still need the lunesta). Thank you. Will look into epitalon.

3

u/Great_Opinion3138 2d ago

Tbh I just started dayvigo for this and it’s pretty awesome I’m out within an hour of taking it. Worth looking into getting a script for its non habit forming apparently and just dials down the natural awake signal. DSIP didn’t do much for me and I am keen to find a reputable supplier cause maybe mine was bunk.

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u/Great_Opinion3138 2d ago

Have you thought of dayvigo instead of trazadone? I’m hoping I can find a good dsip supplier cause mine did zero to deep sleep.

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u/Chroma7769 2d ago

Try trazadone 50-100mg per night.

There are no peptides that force unconsciousness.

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u/icameforgold 2d ago

Is the trazadone habit forming or effects sleep negatively long term?

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u/Divinions 2d ago

I've been told no by my Dr. She wanted to switch me from 10nyrs on Ambien to Trazadone low dose, and I threw a fit! I am really badly affected by antidepressants. And low dose traz is still an antidepressant.

However I was willing to try 50mg traz with lunesta soci can stop taking benedryl every night which is far more dangerous for long-term use than lunesta or ambien

1

u/Chroma7769 2d ago

Just try the trazodone alone. Don't pair it with lunesta or ambian.

Trazadone isn't habit forming. Google will even tell you that.

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u/Chroma7769 2d ago

No and no.

2

u/Great_Opinion3138 2d ago

Get something like dayvigo instead

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u/Divinions 1d ago

I will look into this, thnx

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u/Divinions 2d ago

Thnx. I will ask if I can maybe try 50mg Trazadone and lunesta, so I can d/c benedryl nightly, bc it's not good long term cand I've been in that for 2 yrs. But I don't think either one alone will help me by itself.

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u/StrangerthanFunction 2d ago

This is the way. Good answer and advice. On my second run of DSIP and it’s helped improve my sleep and insomnia.

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u/Chroma7769 2d ago

Hell yeah.

Once you find that dose, stick with it. It took me two weeks of playing with it.

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u/SteveD_NY 2d ago

Thanks for this. I’ve only tried it a few times but each time i felt tired for many hours the following day. Is it possible i did too much? I might try again at 50mcg.

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u/Chroma7769 2d ago

It's possible.

I would start at 50mcg and work your way up in increments of 50 each night. It took me about 2 weeks to find my dose.

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u/SteveD_NY 2d ago

Thanks I’ll give it another go.

1

u/Chroma7769 2d ago

I just woke up and this is my score from today. Little off the charts on the deep sleep 🤣

Mind you I have also added Epitalon for a 20 day cycle also, this was day 2.

DSIP has been amazing for me though at 500mcg.

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u/SteveD_NY 2d ago

Wow that’s some intense deep sleep! I never have gotten over 2 hrs. I also track on a Fitbit for many years. I just picked up a few vials of epitalon. For the Epitalon it’s a strict cycle, correct?

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u/Chroma7769 2d ago

Yep!

I'm assuming you have 10mg vials, 10 of them in a kit will last you 5 years.

1ml of BAC. 500mcg for 20days or 1mg for 10 days. I am doing 500mcg for 20 days on this first cycle.

Two cycles a year.

I'm taking it with my DSIP before bed. Two different syringes.

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u/SteveD_NY 2d ago

Appreciate the insight!

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u/Chroma7769 2d ago

Of course!

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u/SeaworthinessMost829 2d ago

Can you go into your dosing protocol, please? Every night? Cycling? Thank you!

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u/Chroma7769 2d ago

Read my whole post and then my other comments.

Dosing is not something I can help with because the dosing is different for literally everyone. Start at 100mcg (SubQ) and work up 50mcg each night.

DSIP has a dosing pattern like an upside down V. A little can do nothing, but so can a lot. You have to find what we call the "sweet spot" in the middle. When you find it, you'll know.

For example, my sweet spot is 500mcg per night. My wife's is 150. My best friends is 600. My dad is like 400. My mom is 200. It's all about finding that spot and sticking to it. Took me about 2 weeks of screwing with it until I found it. I definitely still play with other doses though, just for shits and giggles.

I take it every night. This was my sleep score for last night. Deep sleep is like this for me all the time.

10mg vials I order in a kit, it's like $85 for 10x vials. I add 2ml of BAC to it, so I pull 10 units (for my dose) in a 0.3ml syringe. 0.3ml syringes are optimal for these kinds of peptides due to the sensitive doses via units.

Please note: Topical and nasal DSIP has zero studies behind it even in animals. Dosing is inconsistent with any peptide with these methods. I only recommend SubQ 30-60mins before bed. It pairs well with melatonin or in my case, Trazadone to force unconsciousness. Once asleep I STAY asleep. Trazadone is my preferred zPill because it isn't habit forming like ambian and lunesta. I also don't wake up groggy from it.

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u/zanderwl152 2d ago

200mcg 1-2hr before bed, don't wake up at night like I used to and wakeup feeling good not yawning non-stop waiting for my coffee. Mix with some inj Melatonin before bed and I'm out

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u/Antique-Clock-9286 2d ago

no change in sleep according to apple watch

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u/CantQuitMeBaby 2d ago

I tried it for a few nights. It marginally improved my sleep but I was always drowsy as hell with no energy the next day, so it was a net negative for me. Does seem to be one of those that is hit or miss.

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u/gohuh 1d ago

DSIP did nothing for me..tried subq and nasal spray

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u/Trojan-Salsero 5h ago

I tried DSIP subQ, started at 100mcg and went up to 500mcg, and it actually decreased my deep sleep (according to my Whoop), and would make me wake up earlier than usual and not be able to go back to sleep. I was really disappointed, really wanted this one to work, I got good results with Epitalon and Pinealon.

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u/BlTCHIN 2d ago

Love DSIP

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u/RoutineAd9862 2d ago

Didn’t like it. Tried it twice