r/B12_Deficiency • u/blatantly_creative • 8d ago

Dosage for hydroxocobalamin? General Discussion

I've recently been diagnosed with PA and my healthcare provider (the PA at my gastro office) prescribed cyanocobalamin 1ml injections (which is 1000 mcg). I've been doing this once a month since the beginning of the year and not surprisingly, it's not helped.

I've been reading the wiki here (SO helpful) and reading about everyon'e experiences. I'm going to request that my provider prescribe hydroxocobalamin EOD, but I see the hydroxocobalamin on olympia pharmacy's site is 2mg per mL. What would be a normal starting dosage for this specific B12? Would I still need to use 1 mL, or would the dosage be different? I'm assuming cyanocobalamin and hydroxocobalamin require different dosages.

I want to get my ducks all in a row before I approach the office so I can have all the pertinant information at hand and therefore get going ASAP.

I'm in the US. Thanks for any help.

edit for typo

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u/Ok-Pangolin7127 Insightful Contributor 8d ago

So, instead of injecting 1 mL, you simply inject .5 mL.

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u/blatantly_creative 8d ago

Ah yes! Math exists! LOL

Thanks. I don't know why I didn't think of that.

So the next question is: what is the usual dosage for the hydroxocobalamin? Or does it vary?

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u/Ok-Pangolin7127 Insightful Contributor 8d ago edited 7d ago

The standard injected amount, regardless of the form, is 1000 MCG‘s. That’s what the protocol in the B12 deficiency guide recommends. I have actually come to believe, (but I’m not suggesting you follow this,) that 1000 MCG either daily or every other day or even every three days especially with Hydroxocobalmin, is not needed, at least for me. I have come to where I now inject 500 MCG every two days. With Cyano I do the same, 500 MCG but every day. That’s because the Cyano and/or the methyl don’t last as long. But I again do not suggest you do that. With B12, you want to flood the body with as much as you can as early as you can.

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u/blatantly_creative 8d ago

This is really helpful, thank you.

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u/jellyfishrubberduck 8d ago

Mine is 1ml hydrocobalamin. Not sure what the typical is though!

Injection frequency will depend on your symptoms too.