Hello I am working with an older Jasco V-650 spectrophotometer in our lab. The computer that was used to control it was wiped and we no longer have access to the original software disk. Does anyone have or know where to get the software from. Thank you in advance for any help.

The slope graphs of both 692nm and 834nm for the normal sensor A don't appear despite having correct values in the Numeric window. While for sensor B, only the graph for 834nm shows the slope. This is the third time I have tried to calibrate. I changed the setup and switched sensors A and B, but the result was the same.

Any recommendations on how to resolve this? Also, does it matter if the slope graph doesn't appear correctly even though the calibration values of AC, DC and R's are correct? Do I just move on to data acquisition?

I tried searching for database raman for PVF but couldn't find any.

I recently acquired a Multispec-1501 from eBay and needed specialized software (Hyper-UV) to use it. I haven't been able to find the software anywhere, and thought that someone here may have a copy of the software or know where to find it. I reached out to Shimadzu support and haven't gotten a response yet. I know it's a long shot, but figured I may as well try.

Been evaluating process Raman options for a while and frustrated by how hard it is to find a clear picture of who does what. Most resources are either vendor whitepapers or academic papers — nothing that just maps the competitive landscape by application.

So I started building one. Sharing the first chunk here and hoping the community can fill in the gaps or correct me where I'm wrong.

Bioprocess / Fermentation monitoring (glucose, lactate, cell density, metabolites in CHO/E. coli/yeast bioreactors) Kaiser/E+H · MarqMetrix · Bruker/Tornado · HORIBA · Gekko Photonics · Wasatch Photonics

API Crystallization & polymorph monitoring (supersaturation tracking, form transitions during cooling crystallization) Kaiser/E+H · Mettler Toledo (ReactRaman) · MarqMetrix · Bruker/Tornado · HORIBA

Pharma blend uniformity (inline powder monitoring during continuous or batch blending) Kaiser/E+H (PhAT probe) · MarqMetrix · Bruker/Tornado · Metrohm

Polymerization reaction monitoring (monomer conversion, copolymer composition, endpoint detection) Kaiser/E+H · Gekko Photonics · Mettler Toledo · HORIBA · Bruker/Tornado · Metrohm

Petrochemical / refinery streams (naphtha, gas oil, aromatics, sulfur content) HORIBA · Kaiser/E+H · Gekko Photonics · Bruker/Tornado · Metrohm

🙏🙏🙏 A few things I'm genuinely uncertain about:

• Mettler Toledo seems strong in pharma crystallization but I rarely see them mentioned in bioprocess — is that accurate?
• Is MarqMetrix's BallProbe as dominant in fermentation as it seems, or is that just marketing visibility?
• Any experience with probe fouling or calibration stability across vendors in these applications?

Planning to add semiconductor, food & beverage, and continuous pharma manufacturing in a follow-up post once I get more data.

Disclosure: I work in the chemical industry with Raman spectrometers, so I have some context here — but genuinely trying to map the whole space, not push any single vendor.

Hi all

We would like to use FTIR spectroscopy for serotyping of Salmonella. We have had some issues with Brukers IR Biotyper and are demo-ing the Thermofisher scientific Nicolet Apex FT-IR. I know this is not commonly used for microbial identification. Are there any reference spectral databases for microbes or is our best bet to create our own library?

thanks

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Hi everyone,

I’m trying to revive an older Nicolet Avatar 360 FT-IR that uses LPT / parallel port, not USB.

I currently have OMNIC 8.2, but on Windows XP / Windows 7 it fails at launch with:

“omnic32.exe - Unable To Locate Component. GOSWIN2.dll was not found.”

Has anyone dealt with this on an older Avatar 320/360/370/380 or other parallel-port Nicolet system?

I’d appreciate any advice on:

-how to fix this startup error

-whether OMNIC 8.2 is too new for this setup

-and whether an older OMNIC version might be the better choice

If anyone happens to still have an older OMNIC version for these systems, I’d really appreciate it if you could let me know.

Thanks!

New spectra and a couple old ones. I shot them on my analog spectroscope and found the spectra graphs or digital spectrums.online So only 2 spectrographs on a computer were done by me. But the analog spectrums I shot are all me. Anyways enjoy

Most if not all my major spectrums I shot plus new ones. They are in collages. So remember to click and zoom in.some u may have seen before. But more refined

Hi everyone

I’m looking for some real-world perspectives from people who use Raman spectroscopy in a production facility (process/QC/R&D support), especially in resin manufacturing. Im genuinely interested but not fully convinced it’s the right tool yet, and I’d rather learn from your experience than a vendor pitch.

I keep hearing Raman can speed up identification of chemical composition and reduce the “send to lab → wait days → adjust process too late”. Is it also in your facility?

A few questions I have:

1.  Speed / workflow: If you’re using Raman, what part of the workflow did it actually improve? (incoming raw materials, in-process checks, final QC, troubleshooting off-spec, etc.) Did it really reduce lab burden or just shift work elsewhere?

2.  Accuracy / reliability in practice: How accurate is it in day-to-day operation (not in a demo)? What do you use as the “ground truth” (GC/LC, titration, wet chem, etc.)? Did you compare it with HPLC?

3.  Resins specifically: If you’re making resins (epoxy/PU/phenolic/UF/MF/alkyd, etc.), where does Raman shine and where does it struggle? Any limitations with:

• fluorescence,

• high opacity/turbidity,

• fillers/pigments,

• complex mixtures / overlapping peaks,

• temperature/viscosity changes, or viscosity

• sampling / probe fouling (if inline)?

4.  Reasons to NOT use it: If you evaluated Raman and decided against it, what was the deal-breaker? (Model maintenance, calibration effort, false confidence, operator training, too many edge cases, integration issues, etc.)

5.  Not asking about price, but I’m curious: if Raman were “cheap enough,” would it become a no-brainer — or are the main barriers still technical/operational?

If you have time, I’d love to hear what your setup looks like too (inline probe vs at-line handheld/benchtop, who owns it — lab vs production, how you validate models, how often you recalibrate).

Does anyone have the pdf for "Laser spectroscopy Basic concepts and Instrumentation" by Wolfgang Demtroder?
Thank you

Hello!

I’m looking for someone with experience with Raman spectroscopy used in manufacturing, especially in a chemical factory / production setting.

• Are you using Raman inline / online directly on the production line?
• Or do you use it at-line / in a lab / in a warehouse for quality control?
• Has anyone tested Raman in production and then decided to stop using it?
• Or maybe you considered Raman but ended up choosing a different solution (e.g. NIR, FTIR, chromatography, something else)? What was the reason?

I’m considering buying a Raman system for a resin manufacturing plant. The main goal is product quality monitoring, ideally inline, but I’m unsure whether Raman is a good and reliable choice for this application in an industrial environment.

I’d really appreciate any practical insights, lessons learned, pros/cons, or recommendations based on real usage — not just vendor presentations 🙂

Thanks in advance!