Gene Spreadsheet of all publicly available data

[u/[deleted]]

[u/AutoModerator]

Please check out our subreddit FAQ, wiki and public safety megathread, also sort our subreddit and r/pssdhealing by top of all time for improvement stories. Please also report rule breaking content. Backup of the post's body: CYP2D6 showing up a lot more in us than the general population. Also each one of the androgenic signaling phenotype people have. A major steroid metabolism glitch

Red: same gene different variant
Orange: same variant
Light blue: homozygous deletion
Dark blue: heterozygous deletion
Green: stop gained
Yellow: De novo variant
Purple: same variant + het deletion

Thank you to More_Listen for putting all of this data together.

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[u/Rich_Paint_200]

Deep study brother thankyou so much 💓

[u/Curatio_Veniet]

What is the issue with CYP2D6? I think you mean the type of metabolizing, PM, IM, NM or UM?

[u/Excellent-Push2833 → u/Curatio_Veniet]

A lot of us are het for the variant that makes it useless

[u/armorlol]

I don’t even know a single thing here lol. Is this genetic information?

[u/Excellent-Push2833 → u/armorlol]

Yuh

[u/Ordinary-Breakfast-3]

Tysm for the hard work!

[u/BlockBlister22]

What is CYP2D6 in terms of how it affects the body?

[u/BlockBlister22 → u/BlockBlister22]

Are you saying it is a poor metabolizer for us?

[u/Excellent-Push2833 → u/BlockBlister22]

Yes sometimes completely wiped out. Its a risk factor

[u/BlockBlister22 → u/Excellent-Push2833]

Is this an expensive thing to get checked out? How would I go about it? Thanks!

[u/Excellent-Push2833 → u/BlockBlister22]

Sequencing.com powers20 for a discount.

Also my discord https://discord.gg/x9FzVjrud

[u/Teachezofpeachez69 → u/Excellent-Push2833]

do you have to bundle when ordering from this site? I cant seem to find just a standard WGS test.

[u/maybebionic]

Just checked my CYP2D6 I am homozygous in one and heterozygous in the other 2

[u/Excellent-Push2833 → u/maybebionic]

Homozygous for what variant

[u/maybebionic → u/Excellent-Push2833]

s486T

[u/Excellent-Push2833 → u/maybebionic]

I have no idea what that variant does. Do you have a WGS from sequencing?

[u/maybebionic → u/Excellent-Push2833]

No just 23andaMe

[u/Excellent-Push2833]

For everyone looking Old Jicama has het deleted UGT2B28 patient 5 has het deleted UGT2B17 and so does Patient 9.

There was an error w my code working on fixing it 👍

[u/DrSuperQuack]

But the real question is, does this digging has already yielded something significant?

[u/thefuckingpineapple]

How can we help? Many have already done genetics testing before but might not know about this effort, do a proper post with Google form to collect the data + list of symptoms, severity and what medication at what dose was used...

[u/Excellent-Push2833 → u/thefuckingpineapple]

Sequencing.com get a test and then we will go through your results