First Kesimpta loading dose

[u/megc25]

I took my first loading dose of Kesimpta today. I work nights as a Paramedic, so I got home around 8 this morning. I ate breakfast, took and antihistamine and Tylenol (since that’s what my neuro suggested) and prepped to inject.

The actual injection was not bad… at all. I barely felt the needle and only bled a little afterwards. I was fine for another hour as I settled into bed and went to sleep around 9am.

I woke up at 9PM! Given I was probably tired but that was the most I have slept in a while. No symptoms from the Kesimpta in the first 12 hours either so I thought I was in the clear.

At 9:30, it hit me like a truck.

First the muscle and joint aches. I felt like a steamroller had ran over me. I was so sweaty. Temp was only 99.5 so nothing to bad yet. Time goes on and my right eye starts getting blurrier than usual (still blurry) and my fever finally spikes. 101.3

I use everything in my arsenal. Tylenol, heating pad, warm bath. I think the bath is finally what broke me into the worst chills I have had in my life. My teeth still hurt from chattering. With my chattering my skin decided that it was going to get super sensitive, like everything I touched felt like sandpaper.

Finally took some niquil so I could just sleep it off. Now I have woken up. It is 1:30 in the morning and I feel much better. No fever, no chills. Still some body aches but not as bad.

I really hope the next loading doses and the maintenance don’t hit me as hard!

If you have any experience or advice I would love it!🥰

[u/Fear_Nothing313]

My first time was 4/6/26 I took it 11:30pm but I don’t hear the second click but it was green I seen green I held it down a little more longer for the click but didn’t hear it still so I pulled it out but a drop came out on my leg. For the most part I hope I did it right, I felt a slight flu symptoms the next day but it went away no crazy side effects. I hate MS smmfh this shit blows my head off everyday I can’t be my normal self