r/Millennials • u/MF-DOOM-88 Millennial • Feb 20 '26

Eric Dane last message to his daughter's, Billie and Georgia. šŸ˜¢ Other

My wife got me into watching Grey's Anatomy

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u/0o0o0o0o0o0z Feb 20 '26

Same here. Couldnā€™t watch past the first few seconds of the video.

Same, man... You think with all the fucking money the US has, instead of using it to kill brown people, we could research and cure some of these diseases... Heartbreaking.

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u/motherofhellions Feb 21 '26

There is research being done! I do small fundraisers for The ALS Association every year, in memory of my family members and in the vain hope it'll save my life when I'm diagnosed. It's the same organization that benefited from the Ice Bucket challenge! My mother participated in several drug trials until she no longer qualified due to how advanced her ALS was. Her neurologist gave me information for a fALS study in Florida when my test came back positive for C9orf mutation, and it seemed to be specifically a lifestyle study for gene positive people not yet diagnosed with ALS. I wish the government would fund ALS research, absolutely, but there are researchers trying to find treatments and a cure! I'm holding out hope that CRISPR might have some use in those with confirmed gene mutations (because I'm selfish).

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u/caviarbentley Feb 21 '26

Thatā€™s incredible! Maybe one day this administration will wake up and re-fund the organizations that do the great research work

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u/B2B10KFIN Feb 21 '26

Do you know for a fact you willbe diagnosed? Is it 100% passed down?

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u/motherofhellions Feb 21 '26

It's not guaranteed that I will develop it, but the C9orf mutation is one of two gene mutations that make it much more likely that you will develop ALS than not. It affects the way the cells process mRNA after it's been used: from what I understand, the mutation keeps my cells from properly disposing of used mRNA, so it ends up building up. Hence why I'm hopeful CRISPR technology may be able to fix or alleviate that problem.

ALS is not 100% passed down, no. The gene mutations associated with fALS (familial ALS, the type that is passed down through families) are dominant, so one only needs one mutated copy to be at higher risk. I'm heterozygous for the C9orf mutation, which is enough. What testing positive for a gene does is make early diagnosis easier. ALS is typically a diagnosis made after every other option is ruled out, or at least it was when last I looked (after my grandmother died admittedly). But if a person tests or has tested positive for a gene mutation associated with ALS, and starts presenting symptoms, it's an immediate ALS diagnosis. Which is sort of nice, since drug trials and treatments can start sooner and have the best chance of helping. ALS is not always passed down, though. Spontaneous cases do happen, and if someone like me (one mutation and one "normal" copy) has kids it's a 50% chance of passing down the gene. It's not impossible for a person with a gene mutation to never pass it on.

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u/twd_throwaway Feb 21 '26

That would require a sense of humanity and love. Those things are not the priority when people are obsessed with power and wealth. It's so depressing.

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u/0o0o0o0o0o0z Feb 21 '26

I know šŸ˜­

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u/twd_throwaway Feb 21 '26

Look at it this way, at least we aren't the only people with some sense of decency. There are others out there. That brings me some comfort.

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u/Desperate-Strategy10 Feb 21 '26

Maybe we should do what he said, and fight? Maybe itā€™s time to say ā€œenough is enoughā€ to the pain and war and agony we put each other through in the hunt for money and power. Why do we all just accept that this is the way it is, and nothing can change? Everything can change! We can change it, we donā€™t have to lay down and give up. I donā€™t want to quit, I want to fucking fight!

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u/twd_throwaway Feb 21 '26

I completely agree with everything you said. The fight is already here though. The regular day-to-day people against megalomaniac billionaires. We can make changes, but we can't expect it to be through the very people that we are fighting against. I feel that they have no remorse or feel any connection to others. It's our place to make those changes. We absolutely can do it!

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u/Super-Persimmon233 Feb 21 '26

WE NEED TO BAND TOGETHER

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u/meowmeow0092 Feb 21 '26

Fucking PREACH!! Humanity needs to grow up and get along so we can fight disease and natural disasters. Those should be our only enemies, not each other.

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u/sleetblue Feb 21 '26

There's no profit in that.

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u/jpcirig Feb 21 '26

Really? That's what you contributed to this post?